tyk2 Phenotypes

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Phenotypes

XB-GENEPAGE-993651

Gene Symbol: tyk2 Gene Name: tyrosine kinase 2

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (6 sources): Immunodeficiency, Increased circulating IgE level, Recurrent fungal infections, Recurrent mycobacterial infections, Recurrent respiratory infections, Recurrent viral infections
Mouse (27 sources): abnormal T cell differentiation, abnormal T-helper 1 physiology, abnormal brown adipose tissue morphology, abnormal common myeloid progenitor cell morphology, abnormal fat cell differentiation, abnormal mitochondrial physiology, abnormal nitric oxide homeostasis, abnormal response to infection, abnormal splenocyte physiology, decreased IgG1 level, decreased IgG2a level, decreased energy expenditure, decreased interferon-gamma secretion, decreased macrophage nitric oxide production, decreased susceptibility to induced arthritis, disorganized mitochondrial cristae, impaired adaptive thermogenesis, increased cholesterol level, increased circulating interleukin-12 level, increased prepulse inhibition, increased susceptibility to Herpesvirales infection, increased susceptibility to Herpesvirales infection induced morbidity/mortality, increased susceptibility to Picornaviridae infection induced morbidity/mortality, increased susceptibility to Riboviria infection, increased susceptibility to Riboviria infection induced morbidity/mortality, increased susceptibility to parasitic infection, increased susceptibility to viral infection induced morbidity/mortality [+]
View all ortholog results at Monarch