| Monarch Ortholog Phenotypes
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Human (2 sources):
Cellular immunodeficiency,
Chronic lymphatic leukemia
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Mouse (27 sources):
abnormal blood urea nitrogen level,
abnormal spleen marginal zone morphology,
abnormal type III hypersensitivity reaction,
autoimmune response,
decreased IgG2b level,
decreased IgG3 level,
decreased large unstained cell number,
decreased marginal zone B cell number,
decreased naive B cell number,
increased B cell derived lymphoma incidence,
increased B cell proliferation,
increased IgG1 level,
increased IgG2a level,
increased T cell proliferation,
increased anti-double stranded DNA antibody level,
increased anti-histone antibody level,
increased anti-nuclear antigen antibody level,
increased anti-single stranded DNA antibody level,
increased autoantibody level,
increased circulating creatinine level,
increased follicular B cell number,
increased grip strength,
increased neutrophil cell number,
increased pre-B cell number,
increased spleen germinal center number,
premature death,
renal glomerular immunoglobulin deposits
[+]
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.