| Monarch Ortholog Phenotypes
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Human (28 sources):
Abnormal myelination,
Abnormal pinna morphology,
Blepharophimosis,
Broad forehead,
Camptodactyly,
Delayed ability to walk,
Delayed speech and language development,
Downslanted palpebral fissures,
Downturned corners of mouth,
Feeding difficulties,
Flat face,
Generalized hypotonia,
Global developmental delay,
Growth delay,
Hypertelorism,
Intellectual disability,
Intrauterine growth retardation,
Long philtrum,
Microcephaly,
Narrow mouth,
Ptosis,
Round face,
Short philtrum,
Short stature,
Strabismus,
Talipes equinovarus,
Wide mouth,
Wide nasal bridge
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Mouse (34 sources):
abnormal cell cycle checkpoint function,
abnormal dentate gyrus morphology,
abnormal embryo morphology,
abnormal hippocampal mossy fiber morphology,
abnormal hippocampus CA1 region morphology,
abnormal hippocampus development,
abnormal hippocampus neuron morphology,
abnormal hippocampus pyramidal cell layer,
abnormal hippocampus region morphology,
abnormal neocortex morphology,
abnormal nest building behavior,
abnormal neuronal precursor cell migration,
abnormal neuronal stem cell morphology,
abnormal radial glial cell morphology,
decreased body size,
decreased corpus callosum size,
decreased dentate gyrus size,
decreased food intake,
decreased neocortex size,
decreased neuronal precursor cell number,
decreased neuronal precursor proliferation,
decreased radial glial cell number,
embryonic growth arrest,
embryonic lethality during organogenesis, complete penetrance,
embryonic lethality during organogenesis, incomplete penetrance,
embryonic lethality, complete penetrance,
increased startle reflex,
increased subiculum size,
limb grasping,
nervous system phenotype,
no abnormal phenotype detected,
postnatal lethality, incomplete penetrance,
prenatal lethality, incomplete penetrance,
thin cortical plate
[+]
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.