ncf1 Phenotypes

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Phenotypes

Gene Literature (0)

Nucleotides (110)

Interactants (47)

XB-GENEPAGE-999122

Gene Symbol: ncf1 Gene Name: neutrophil cytosolic factor 1

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: ncf1 assayed (5 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (42 sources): Abnormality of neutrophils, Absence of bactericidal oxidative respiratory burst in phagocytes, Cellulitis, Chronic pulmonary obstruction, Cutaneous photosensitivity, Decreased activity of NADPH oxidase, Discoid lupus rash, Eczematoid dermatitis, Fever, Gingivitis, Granulomatosis, Hepatomegaly, Hypermelanotic macule, Immunodeficiency, Impaired oxidative burst, Inflammatory abnormality of the eye, Liver abscess, Lymphadenitis, Lymphadenopathy, Macule, Malabsorption, Mediastinal lymphadenopathy, Meningitis, Osteomyelitis, Otitis media, Pyloric stenosis, Rectal abscess, Recurrent Aspergillus infections, Recurrent Burkholderia cepacia infections, Recurrent E. coli infections, Recurrent Klebsiella infections, Recurrent Serratia marcescens infections, Recurrent Staphylococcus aureus infections, Recurrent bacterial skin infections, Recurrent pneumonia, Recurrent respiratory infections, Sepsis, Sinusitis, Skin ulcer, Splenomegaly, Tracheoesophageal fistula, obsolete Eczematoid dermatitis [+]
Mouse (35 sources): abnormal angiogenesis, abnormal bile duct morphology, abnormal cardiac muscle contractility, abnormal intestinal goblet cell morphology, abnormal kidney morphology, abnormal locomotor activation, abnormal macrophage physiology, abnormal postnatal growth, abnormal response to cardiac infarction, abnormal response to infection, abnormal spatial learning, abnormal tracheal smooth muscle morphology, abnormal vascular endothelial cell physiology, abnormal vascular smooth muscle physiology, abnormal vascular wound healing, cardiac hypertrophy, decreased airway resistance, decreased mean corpuscular volume, decreased susceptibility to Orthomyxoviridae infection, decreased vasoconstriction, dilated heart left ventricle, enhanced long term potentiation, enlarged lymph nodes, granulomatous inflammation, immune system phenotype, impaired cued conditioning behavior, impaired granulocyte bactericidal activity, increased acute inflammation, increased angiotensin I-converting enzyme activity, increased lung compliance, increased sensitivity to induced morbidity/mortality, increased systemic arterial blood pressure, oxidative stress, reduced long term potentiation, skin lesions [+]
View all ortholog results at Monarch