[provisional- machine annotated only] Gene Symbol: rad17 [Predicted: Source is Human Entrez Gene] Gene Name: RAD17 homolog [Predicted: Source is Human Entrez Gene] Synonyms: xrad17 Add Xenopus synonyms Gene Function: Checkpoint RAD17-RFC complex, RAD17/RAD24 component Interactants: atr(10) , chek1(9) , antxr1(5) , atm(5) , clspn(5) , hus1(4) , ercc4(3) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		NCBI Nucleotide >XM_002934815|PREDICTED: Xenopus (Silurana) tropicalis RAD17 homolog (rad17), mRNA CCACGCAGTGAGCGCTGAGTCCGTATGAAGTTTTCCTGTTGGAACTTAGCTGTCGCCTTACATATGTTATGTTATCACCTGCTGAGCTGATGGGAATAGGACACTTTGATAATGTCAAAAACATCTTACAGAAGGAAGGTAACCTCCACTAAGATTACAGATTGGGTTGAGCCATCTTTTGAAGACTTCTTTGGAAACACAAGCAAAGTTTCATCTCAGACATCAGGAATTGTTAAAAGATGCGCACAATCAAAGAGTGAGTCTTCCACAGAGAACAAACAGGGCAAGAAGAGAACAAATCCATTTACTAAAGACCATACTAATGATAAAAATCAACAGACTTTTGACTACTCCCAGAATGAACCCTGGATTGATAAATACCGACCAGATGTTCAGGCAGAGCTTGCAGTACATAAGAAAAAGATTGAAGAGGTTGAGGCTTGGCTGAAAACCCATGTGGAGAAGAGGACACAGAAGCAGGGTGGTCACATATTATTACTAACAGGGCCACCAGGCTGTGGAAAGACAGCAACAATTCAAGTTCTTACTAAGGAAATGGGGATTCAGGTTCAGGAATGGATCAATCCTCTTATGCAGGAATACAGACAAGAAGATCGACCTGAAGTTTTTGATAGAGATATGGGATTTCAGCCTTTCACCAGTCAGTCTCAGACATCTCTCTTTCATGACTTTCTCTTAAGGGCAAACAAATACAACAAGTTGCAGATGGTTGGTGAATCTTTAAGCACAGACAGAAAAATCATTGTTGTGGATGATATGCCTAATCAGTTTTATCGAGACCCCTCTTCTTTACATGATATACTTAGGAGATTTGTAAAAACAGGCCGCTGCCCTTTAGTGTTCATAATATCAGATAGTCTGAGTGGGGAGAGCCATCAACGGAGACTTTTCCCCAAGGAAATCCAAGAGGAACTAGTGGTTAATAATATAAGTTTTAACCCTGTAGCACCAACAACCATGACAAAAGTTTTGACCCGAATTGCTAGCACAGAGGCAAATATGAGTGGTGGGAAAATTATCATTCCTGATAAAGCATCACTAGATTTAATCTGTACTGGCAGTTCAGGGGATATCCGAAGTGCAATTAATAGTCTTCAGTTTTCAGCCCAGAAAGGTTCATTTTTGACAAATAATACCTGTTCTAAAAGCAGGGGGAAAGCAACAAAATCAGGAAAAACCTCTTCCAAATCAAAGTCTAAAAAGGGGTCACAGAAAGGTGGAGAAAATATAGATGAAGTACAAGCAATTGGTGGAAAAGATGCTTCACTCTTTTTATTCCGTGCCTTGGGAAAAATACTTTACTGCAAACGAGAGCCCCTACCAGAGGATACAGATATTTATCGTTTGCCTGCTCACTTATCTGAATATAATCGAGATTTGCTTCTTGTCCTTCCAGAGGCTGTTGTAGAAAAGTCTCACATGAACGGCGATTTATTCAATTTATATCTGCATCAAAATTATTTGGAGTTCTTCATGGAAATTGATGATGTAGTCCGAGCTAGCGAATATCTAAGCAGCGCCGATGTGCTCTCTGGTGATTGGAATTCCCGTTCCACGCTGAGTGTGTACAGTTCTTCAGTGGCAAGCAGAGGGATCATACATTCCAACAGTGCCAGAGCTTTTGCCAATTGTCAAGGGGGAGTTGGTTTCAAGCCACTACATAAACCACAGTGGCTAGTAGCTAATAAAAAGCACCAAGAAAATTGCCTTGCTGCAAGGTCACTCTTCTCAAGCTTCTGTTCCTCTCCAATGTGTCTTCAAACTCAGGTGTTACCTTATCTGGCAATGCTCACAAATCCATTGAGGAATCAGTCACAAATTACATTTATTCAAGATGTTGGTCGATTACCATTGAAAAGGCAATTAGGAAGGCTAAAACTTGAAGCTCTCACAGACAAAGATCCTGGACTCCCAGATGTTGATAGTGGTGAAGAAGATAACCTTACTGAATTGCAAAGAGAAAAGAATAACATGACCAATTCCAAAGGTGATAGAAAGGATCTGTTGTCCAGTGAAGGAGCAGAAAGTGAATTGCCAGCCAGTCAGCCCCAACCAGTTGCAGCACAGGCAGTTATGGAGGATGAAGAGTTAAAGATAGAAGAGTATGACAGTGACTGATATCTATCAGCATTGCTTACTCTTATTTGTTTGGACTTATGGGACAAGCTTCTGGTTAGCAGGTCATTTATTAATAAATTCAGTTAAGTTATACAGACTGCATCCCAGTGTAAGTGTGTGTGGAAGGAACAAAACTTCCTGTTTGGAACAGGTCATAAGAAGAACTGGTTTGCAGAGCTGCAGGCTTTCCATAGCACTTAGAGCCAGGCCACGTAATAATTGCTTTTTTAATATCCACTGCAAAGGGTGGTGGATTGGCAATTATTGTGCTAAAGATATACTGCTGTAAAGTAATTTATACACAAGATGGAGAACCTACAATGTGAATGTAAGTTCTATACTGAACTATTTAACAGTGTAAATAAACTTTTTTTTTTTCTCCATTTGAAA	Refseq >NM_001089097|Xenopus laevis RAD17 homolog (rad17), mRNA TAGAAATTTGGTACTTCTATAGCGGTTTCCGTGAGAAGTTTCACGCTGGCTTTTGGTTTAACGTTGAACTCTTTGGGAGCGTAAGCGAGCAATGCCCTGCTGTCTAATTGCCTCCCTTTGCTTCCTCTGACTGTTTCCGGTGTTGGCAGTGTGCCAGGGAGGATCTTGCCCACACATTCCAGGGCATATTCCTGTTGCAGTGGTCTGTTCTCAGGTTCTCCCTGAGTGATTGTTATGAGACCCACTGTATGTTATATGTCATCATCTGCTGAGCTGATGGGAATAGGACACTTTGATAATGTCAAAAACATCTTGCAGAAGGAAGGTAACCTCCGCTAAGATTACTGACTGGGTTGAACCATCTTTTGAAGACTTCTTTGGAAACACAAGCAAAGCTTCATCTCAGACATCAGGAATTGTTAAAAGATGCGCCCAAACAAAGAATGAATCTTCCTTAGAGAACAAACAGGGAAAGAAGAGAATCAATCCATTTACAAAAGACCATGCTAGCGATAATAATCAACATACTTTTGACTACTCCCAGAATGATCCCTGGATTGATAAATACAGACCAGAAATTCAGGCAGAACTTGCCGTGCACAAGAAAAAAATTGAAGAGGTTGAGGCCTGGTTGAAAACCCATGTGGAGAAGAGGCCACAGAAGCAGGGGGGTCAGATTTTATTACTAACTGGGCCCCCGGGCTGTGGAAAGACTGCAACAATTCAAGTGCTTACTAAAGAAATGGGGATTCAGGTACAGGAATGGATCAATCCTCTAATGCAGGAGTTCAAACAAGATCTACCAGAAGTTTTTGATAGAGATACGAGGTTTCAGCCTTTCACCAGTCAGTCTCAGACATCTCTCTTTCACGACTTTCTCTTAAGGGCAAATAAATACAACAAACTACAGATGGTTGGTGAATCTTTAAGCACGGACAGGAAAATCATTGTTGTAGATGATATGCCTAATCAGTTTTATCGAGACCCCTCTGCTTTACATGATATTCTTAGGAGGTTTGTAAAAACAGGCCGCTGCCCTCTAGTGTTCATAATATCAGACAGCCTGAGTGGGGAGAGCCATCAACGGAGACTTTTCCCGAAGGAAATCCAAGAAGAACTAGTAGTTAACAATATAAGTTTCAACCCTGTAGCCCCAACAACCATGACAAAAGTTTTGACCCGAATTGCTAGCACAGAGGCAAATGCAAGTGGTGGAAAAATTATCATTCCTGATAAAGCATCACTAGAGTTAATCTGTACTGGCAGTTCAGGGGATATCCGAAGCGCAATTAATAGTCTTCAGTTTTCAGCTCGGCAAGGTTCATCTCTGAAAAATGATAGCTGGTCTAAAAGCAGAGGGAAAGCATCAAAATCAGGAAAACCCTCTTCCAAATCAAAGACTAAAAAGGAGCCACGGAAAGGTGGAGAAAATGTAGATGAAGTACAAGCAATTGGTGGGAAAGATGCTTCACTCTTTTTATTCCGAGCCTTGGGGAAAATACTTTACTGCAAACGAGACCCCGTACCAGATGATACAGATGTTTATCGTTTGCCTGCTCACTTATCTGAATATAACAGAGACTTGCTTCTCATCCTTCCAGAGGCCGTTGTGGAAAAGTCTCACATGAATGGAGAACTGTTCAATTTATATCTTCACCAGAATTATTTGGAATTCTTCATGGATATTGATGATGTAGTCCGAGCAAGCGAATATCTAAGCAGTGCCGATGTGCTCTCTGGTGATTGGAATTCCCGTTCCACACTCAGTGTGTACAGTTCTTCAGTGGCAAGCAGAGGGATCATACATTCTAACAGTGCCAGAGCTTTTGTCAACTGTCAAGGAGGAGTTGGGTTCAAGCCACTACATAAACCTCAGTGGCTTGCAATAAATAAAAAGCACCAAGAAAATTGTCTTGCTGCAAGGTCTCTCTTCTCAACCTTCTGTTCCACACCGCTTGGTCTTCAAACTCAGGTGGTACCGTATCTGGCAATGCTCACAAATCCATTGAGGAATCCATCACAAATTGCATTTATTCAAGATGTTGGCCGGCTACCGTTAAAAAGGCAGTTTGGAAGGCTAAAACTTGAAGCACTCACAGACAAAGATTCTGGACTCCCAGATGGCGAGAGTGGTGAGGAAGATAACCTTACTGAAATGCAAATAGAAAGAAATGACGCTGGCAATTCCATGGCTGATAGAAAGGAACTGTTGTCCAGTCAAGGACTGGAAAGTGAGTTGCCAGCCAGTCAGCCCCAACCAGTTGCAGCACAAGCAATTATGGAGGATGAAGAGTTAAAGATTGAAGAGTATGACAGTGACTGATATCTATCAACATATTGGTTACTCCTATTTCTTTGGACTTACGGGGCAAGTTTCTGGTTAGCAGGTCATTCATTAATATGTTTAGTTGTACGGCCTCCATCCCAGTGTAGGTGTGTTGAAGGAACAATGACAAAACTTTCTGTTGTGAATAGGTCATGAGTGGAACTGGTTTGTGGAGCAGCAGGCTTGTTAAAGCACTTAGTTAGACTGTGTGACAAATTGCTTTTTTAATATCCACTGCAAAAATAGTGGATTGGTAATTATTGTGCTGAAGATGTACTGCTGTAAATTAATTTATACATTACGTACAAGATGGAAAACCTACAATGTGAATGTAAGTTTATATAAAGTTCTATACTGAACTATTTAACTATGTAAATAAATACCTTTTTTCCTCCATGTGAAGAAAAAAAAAAATAAAAAAAAAAAAAAAAAAAAAA
Protein		NCBI Protein >XP_002934861|PREDICTED: cell cycle checkpoint protein RAD17 [Xenopus (Silurana) tropicalis] MSKTSYRRKVTSTKITDWVEPSFEDFFGNTSKVSSQTSGIVKRCAQSKSESSTENKQGKKRTNPFTKDHTNDKNQQTFDYSQNEPWIDKYRPDVQAELAVHKKKIEEVEAWLKTHVEKRTQKQGGHILLLTGPPGCGKTATIQVLTKEMGIQVQEWINPLMQEYRQEDRPEVFDRDMGFQPFTSQSQTSLFHDFLLRANKYNKLQMVGESLSTDRKIIVVDDMPNQFYRDPSSLHDILRRFVKTGRCPLVFIISDSLSGESHQRRLFPKEIQEELVVNNISFNPVAPTTMTKVLTRIASTEANMSGGKIIIPDKASLDLICTGSSGDIRSAINSLQFSAQKGSFLTNNTCSKSRGKATKSGKTSSKSKSKKGSQKGGENIDEVQAIGGKDASLFLFRALGKILYCKREPLPEDTDIYRLPAHLSEYNRDLLLVLPEAVVEKSHMNGDLFNLYLHQNYLEFFMEIDDVVRASEYLSSADVLSGDWNSRSTLSVYSSSVASRGIIHSNSARAFANCQGGVGFKPLHKPQWLVANKKHQENCLAARSLFSSFCSSPMCLQTQVLPYLAMLTNPLRNQSQITFIQDVGRLPLKRQLGRLKLEALTDKDPGLPDVDSGEEDNLTELQREKNNMTNSKGDRKDLLSSEGAESELPASQPQPVAAQAVMEDEELKIEEYDSD	Refseq >NP_001082566|RAD17 homolog [Xenopus laevis] MSKTSCRRKVTSAKITDWVEPSFEDFFGNTSKASSQTSGIVKRCAQTKNESSLENKQGKKRINPFTKDHASDNNQHTFDYSQNDPWIDKYRPEIQAELAVHKKKIEEVEAWLKTHVEKRPQKQGGQILLLTGPPGCGKTATIQVLTKEMGIQVQEWINPLMQEFKQDLPEVFDRDTRFQPFTSQSQTSLFHDFLLRANKYNKLQMVGESLSTDRKIIVVDDMPNQFYRDPSALHDILRRFVKTGRCPLVFIISDSLSGESHQRRLFPKEIQEELVVNNISFNPVAPTTMTKVLTRIASTEANASGGKIIIPDKASLELICTGSSGDIRSAINSLQFSARQGSSLKNDSWSKSRGKASKSGKPSSKSKTKKEPRKGGENVDEVQAIGGKDASLFLFRALGKILYCKRDPVPDDTDVYRLPAHLSEYNRDLLLILPEAVVEKSHMNGELFNLYLHQNYLEFFMDIDDVVRASEYLSSADVLSGDWNSRSTLSVYSSSVASRGIIHSNSARAFVNCQGGVGFKPLHKPQWLAINKKHQENCLAARSLFSTFCSTPLGLQTQVVPYLAMLTNPLRNPSQIAFIQDVGRLPLKRQFGRLKLEALTDKDSGLPDGESGEEDNLTEMQIERNDAGNSMADRKELLSSQGLESELPASQPQPVAAQAIMEDEELKIEEYDSD

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.52799	Xl.23644
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	RAD17
mouse		MGI	Rad17	All(5) Targeted, knock Out(2) Targeted, other(3)
zebrafish		ZFIN	rad17

Publications
First:		DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts. [J Cell Biol 2002]
Most recent:		The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks. [Mol Biol Cell 2013]
		View All Papers

Functional Ontologies
GO: Molecular:		DNA binding
Biological:		DNA repair DNA replication cell cycle
Cellular Component:		DNA replication factor C complex nucleus
EC:
KOG:		[DL] Checkpoint RAD17-RFC complex, RAD17/RAD24 component

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.15156.1.S1_at [+] Str.3361.1.S2_at	Xl.23644.1.S1_at
Affymetrix 2.0			Xl2.23644.1.S1_at

Symbol legend[+]

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