Gene Symbol: nedd4 Gene Name: neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase Synonyms: xnedd4 Add Xenopus synonyms Gene Function: ubiquitin-protein ligase Interactants: nedd4l(60) , sgk1(33) , sgk3(10) , akt1(9) , prkaa1(9) , sgk2(8) , ins(6) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene
mRNA		NCBI Nucleotide >XM_002940255|PREDICTED: Xenopus (Silurana) tropicalis e3 ubiquitin-protein ligase NEDD4-like (LOC100496333), mRNA GAGGTTTGTGCCTCTAGTTCCACGGATGCTTTAGATCACATGATGGCGTCATCCATGGAGATTCTTGGTGTCCAAGCAGAAGAGGAAAGTACACGCATTTTACGTGTGAAGGTTATAGCTGGCATTGGACTGGCAAAGAAAGATATTTTAGGAGCAAGTGATCCTTATGTGAAACTGACTGTGTATGACCCAGCAAATGGGATCCTGTCAAGTGCTCAAACGAAAACTGTTAGAAAGACTTTGAATCCTAAATGGAATGAGGAAATATTATTCAGAGTATATCCACAGAAGCACAGACTTCTCTTGGAAGTATTTGATGAAAATCGCCTGACCAGAGATGATTTTCTTGGGCAAGTGGATGTTCCTCTTCATCAGTTACCAACAGAAAACCCACGGTTGGAGCGACCATATACATTCAAAGACTTTATTCTTCATCCAAGAAGCCACAAATCACGAGTCAAAGGAAATCTACGGTTAAAAATGACATATTTACCTAAAAACAATGGATCAGAAGATGAAAATGCAGAGCAGGCTGAAGAAATGGAGCCTGGCTGGGTTATACTGGACCAACCAGATACATCTTGCCAACCTCAACAAGAACAAGAACTTTCCCCACTACCTCCAGGATGGGAAGAGAGACAGGATATCCTTGGAAGAACTTACTATGTCAGTCATCAGTACAGAAGAACACAGTGGCAAAGGCCTACTATTCAAGATGATACTGCAGCCAATGAAAGCAGGAATGTTCAGTTAGAGGAACAGCATCATCATGCATTCACAACAAGGAGGCAAATATCTGAAGAAACAGAAAGCAGAGATTCTCCAGAGAGCTGGGAAATTATAACAGAAGATGAAACAACAATCTATAGCAACCAGAATGCCCAGCAGGGATCTGCACCAACCAGTGATGCCCAGGCACAAATCACAGAAGAGCTTAGTATAAGGCTTAACATTTCTGGGAATATGCCAAACAGCCGACAGAGCTCTTCCAATGTTCATTCCAACAGAAGAGAGAGCTTGCAGTCATACACTTCAGAAGAACTTCCTACGGTACCAGTTTTATTACCTACATCTTCTGGATTACCACCTGGCTGGGAAGAAAAACATGACGATAAAGGAAGATCATATTACATTGATCACAATAGCAGAACTACTACTTGGGAAAAGCCAAGTAGCCAAGGACCCACGGAAACTTTCCAGACTTCATCTGTCCAGAATGTCCCTGTCATTTTTCAACCACAAACAGCTACCAGGGAATCCACACAGTTATTGGAAACAGAACAAAGATTTCTCCCCAAAGGATGGGAAGTGCGCCATGCACCAACTGGAAGGCCATTCTATATCAATCATGTAACCAAAACAACCACATGGGAAGACCCAAGATTGAAGATTCCAGTACAGCTAAGGCCAAAGCCCCCCATAGATCTATCAGATCTGGGACCACTGCCTCCTGGATGGGAAGAAAGAACTCATAATGATGGAAGAGTATTTTACATTGATCACAACACAAAGCAAACACAGTGGGAGGATCCACGCTTACAAACTGCAGCAATAACTGGACCAATTGATATTCCAAATAGGTTTGAAATGAAGTTACGTCGTACAGCCATTCTTGAAGATTCCTATAGAAGGATTATAGCTGTAAAAAGGCCAGAGTTTCTCAAGGCACGTCTTTGGATAGAGTTTGATAATGAGAAAGGCTTGGACTATGGAGGAGTGGCCAGAGAATGGTTCTTCTTGATTTCTAAAGAAATGTTCAATCCTTATTATGGTCTGTTTGAATATTCTGCCACGGACAACTATACTTTACAAATTAATCCTAATTCTGGTCTGTGTAATGAAGATCACCTTTCGTATTTCAAGTTTATAGGCCGCGTGGCTGGAATGGCAGTATACCATGGAAAGCTTCTTGATGCATTTTTTATTCGCCCATTTTACAAAATGATGCTCCAAAAACCAATTATATTGTATGACATGGAGTCTGTGGACAGTGAATATTACAATTCCCTCCAGTGGATACTAGAAAATGATCCTTCAGGTTTAGATCTGTGCTTCACTGTTGATGAGGAACTTTTTGGACAGACACATCAACATGAGTTGAAGGCTGGTGGTTCACAAATCTTAGTCACAAACAAGAACAAAAAAGAGTACATACATCTTGTTATTCAGTGGAGGTTTATGAACAGAGTTCAAAAACAGATGGCTGCATTCAAAGAGGGTTTCTTTGAACTGATCCCGCAAGACCTGATAAAAATATTTGATGAAAATGAGCTGGAGCTGCTGATGTGTGGCTTAGGAGATGTAGATGTTAACAACTGGCGAGAACATACAAAGTACAAGAATGGATACTCACAAGGACACCAAGTTATACAGTGGTTTTGGAAGGCTGTGCTGATGATGGATGCAGAAAAGAGGATTCGATTACTTCAGTTTGTCACAGGCACCTCTCGTGTGCCCATGAATGGATTTGCTGAGCTGTATGGCTCCAATGGACCACAGTTGTTTACAGTTGAAAAATGGGGCACTCCAGAAAAATTACCTAGAGCGCACACATGCTTTAATCGTTTGGACTTGCCACCTTATGAATCATTTGAGGACCTGTGGGATAAGCTCCATATTGCTATTGAAAATGCTCAAGGTTTTGATGGGGTTGATTAA
Protein		NCBI Protein >XP_002940301|PREDICTED: e3 ubiquitin-protein ligase NEDD4-like [Xenopus (Silurana) tropicalis] MMASSMEILGVQAEEESTRILRVKVIAGIGLAKKDILGASDPYVKLTVYDPANGILSSAQTKTVRKTLNPKWNEEILFRVYPQKHRLLLEVFDENRLTRDDFLGQVDVPLHQLPTENPRLERPYTFKDFILHPRSHKSRVKGNLRLKMTYLPKNNGSEDENAEQAEEMEPGWVILDQPDTSCQPQQEQELSPLPPGWEERQDILGRTYYVSHQYRRTQWQRPTIQDDTAANESRNVQLEEQHHHAFTTRRQISEETESRDSPESWEIITEDETTIYSNQNAQQGSAPTSDAQAQITEELSIRLNISGNMPNSRQSSSNVHSNRRESLQSYTSEELPTVPVLLPTSSGLPPGWEEKHDDKGRSYYIDHNSRTTTWEKPSSQGPTETFQTSSVQNVPVIFQPQTATRESTQLLETEQRFLPKGWEVRHAPTGRPFYINHVTKTTTWEDPRLKIPVQLRPKPPIDLSDLGPLPPGWEERTHNDGRVFYIDHNTKQTQWEDPRLQTAAITGPIDIPNRFEMKLRRTAILEDSYRRIIAVKRPEFLKARLWIEFDNEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDAFFIRPFYKMMLQKPIILYDMESVDSEYYNSLQWILENDPSGLDLCFTVDEELFGQTHQHELKAGGSQILVTNKNKKEYIHLVIQWRFMNRVQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNNWREHTKYKNGYSQGHQVIQWFWKAVLMMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTVEKWGTPEKLPRAHTCFNRLDLPPYESFEDLWDKLHIAIENAQGFDGVD

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC
Synteny		Metazome

Expression		tropicalis	laevis
UniGene
Unigene EST Profile
GEO data			GEO
Images		1 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	NEDD4
mouse		MGI	Nedd4	All(9) Gene Trapped(4) Targeted, knock Out(2) Targeted, other(1)
zebrafish

Publications
First:		Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination. [EMBO J 1997]
Most recent:		AMP-activated protein kinase regulates hERG potassium channel. [Pflugers Arch 2013]
		View All Papers

Functional Ontologies
GO: Molecular:		UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity acid-amino acid ligase activity ribosomal S6-glutamic acid ligase activity More[+] ubiquitin-protein ligase activity
Biological:		protein modification process ubiquitin cycle
Cellular Component:		intracellular
EC:		AcidAmino-Acid Ligases (Peptide Synthases)
KOG:		[O] Ubiquitin protein ligase RSP5/NEDD4

Reagents		tropicalis	laevis
Clones
Affymetrix 1.0		StrEns.7999.1.S1_a_at
Affymetrix 2.0

Symbol legend[+]

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