Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, ...[+]

Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. [-]

             thrombophilia
             cerebral infarction
             cerebrovascular disease
             thrombophilia due to thrombin defect
             prothrombin thrombophilia

          THROMBOPHILIA DUE TO THROMBIN DEFECT; THPH1
          PREGNANCY LOSS, RECURRENT, SUSCEPTIBILITY TO, 2; RPRGL2
          PROTHROMBIN DEFICIENCY, CONGENITAL

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD