bmp4 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Summary

Gene Literature (374)

Interactants (428)

XB-GENEPAGE-483057

Gene Symbol: bmp4 Gene Name: bone morphogenetic protein 4 Synonyms: XBMP-4, bmp-4, xbmp4 Add Xenopus synonyms Gene Function: TGF-beta related peptide growth factor Interactants: chrd(92) , nog(80) , bmp2(53) , otx2(36) , smad1(36) , gsc(31) , shh(27) View All

XB-GENE-483058

XB-GENE-483062

Molecules		tropicalis	laevis
Gene		JGI XT Genome 4.1 Ensembl
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_001017034\|Xenopus (Silurana) tropicalis bone morphogenetic protein 4 (bmp4), mRNA ATTCCAATATTCATTTTAGGAACCAGTTCCATAGTATCATCTCCATCTGCAAACTGCGTCCCGAGTCCCACTGAGCTTTTCCACAAATTTCTGTCCAAGATTGGCAGTCAAGAATCATGGACTGTTTTTCTATGCCTTGTTTTCTGTCAAGACACCATGATTCCTGGTAACCGAATGCTGATGGTCATTTTATTATGCCAAGTCCTGCTAGGAGGCACTAACCATGCCAGCCTGATACCTGAGACGGGCAAGAAGAAAGTAGTGGCCGAGATTCAGGGAGGTAGAAGGTCCGCTCAGAGCAATGAGCTCTTGCGGGATTTCGAGGTGACGCTGCTGCAGATGTTCGGCCTCCGCAAGCGGCCGCAGCCCAGTAAGGATGTGGTGGTGCCCGCGTATATGCGGGACCTGTACAGGCTTCAGTCAGCGGAGGAGGAGGATGAACTACACGATATCAGCATGGAGTACCCGGAGAGACCGACCAGCCGGGCTAACACCGTGAGGAGCTTCCATCATGAGGAGCATTTGGAGAATCTACCAAGCACAGCAGAAAATGGAAATTTCCGTTTTGTGTTCAACCTCAGCAGCATTCCAGAGAATGAGGTGATTTCTTCAGCAGAACTAAGACTCTATAGAGAACAAATAGACCATGGTCCAGCGTGGGAAGAGGGTTTCCACCGGATAAATATATATGAAGTTATGAAACCAATAACAGCAAGTGGACACATGATAAGTAGGCTGCTGGACACACGGCTAATCCACCACAATGTGACACAGTGGGAAAGTTTTGATGTAAGCCCTGCAATTATAAGGTGGACCCGGGATAAACAGATAAACCATGGGCTTGCCATTGAGGTTGTTCACCTCAACCAAACAAAAACTTATCAGGGGAAGCATGTAAGGATAAGTCGATCATTATTACCTCAAGAGGATGCAGACTGGTCACAGATGAGACCGCTTTTAATTACATTCAGCCATGATGGCAGGGGACATGCACTGACCAGGAGGTCAAAAAGAAGTCCAAAACAGCAAAGACCCCGTAAAAAAAATAAACATTGCCGGAGGCATTCTCTTTATGTGGATTTCAGCGATGTTGGCTGGAATGACTGGATTGTGGCACCTCCTGGATACCAGGCTTTTTACTGCCATGGAGATTGTCCATTTCCCTTGGCTGATCACCTAAACTCAACTAACCATGCTATTGTACAAACTCTGGTAAACTCTGTTAACTCAAGCATCCCAAAAGCGTGTTGCGTCCCCACAGATCTGAGTGCTATCTCCATGCTTTATTTGGATGAATATGACAAAGTCGTCCTTAAAAACTATCAGGAGATGGTGGTGGAAGGGTGTGGGTGCCGTTAAGTCTGAGACCCAAACAAAAGACTGTTAAGGGCTGGACTTCTTTCCACTGAACATTCACCTTGACCTTATTTATGACTTTTATGTGCAAATGTTTTGACAATATGATCATATATTTTGACAAAATATATTTATAACTACGTATTAAAAGAAAAAAAATAAAATAAGTCATTATTTTAAACATAAGCTACTTCTTTGTACAATGTGTTTATAAATGTACATTAGGATGAATATGGATTTATATGGGAATAGAGTATTTTTTCTATAAATTACCTTGTGTTAATATTTATTGGCAATATGGCTTAAAACCCCTGCCCCCCGGTAAATGAATGTAAATTAAGCTGAGGCATATTGCTGTCTGCATGTCAGTTGAATTTAAATTCCCTACTTCTGGGAATAGAACTACTTGACTTGCTAACCTGTGTGTGTGTTTATTTTTTCAAATTCATTTGCATGGAGACTCTGAAACACCTATGTTGTTATGCTAAAGTCTGTCATACCTCCCACCCTCCTGTTGTATAGCCTAAGTTCAAAGCTATGCATAGTTTTTTTTTTTTTAAAACAGAGGTTAGCAAAAGGGCTGTTAAGTAGCGAAGTACTTTGGAAAATAATTTTTCTTTAAACATCAAAGGTTACAGGATTCTTTTGAAGGTTAAAACACATTAAAAATGCACATAGACTTGACAAGTGATATGTTTAAAATTGACAGATGTTTTTATTTGTATTTTTTTACCATAAAAAAAAATCTAGAAATTTCAAATAAATCTGAT	Refseq >NM_001088032\|Xenopus laevis bone morphogenetic protein-4 (LOC397874), mRNA ATATTCCAATATTCATTTTAGGAGCCAGTTCCTTAGTATCATCTGCAAACTGCGTCCCGAGCCCGTGCACTGAGCTTTTCCACCCATTTCTGTCCAAGATTGGCTGTCAAGAATCATGGACTGTTTTTCTATGCCTTGTTTTGTGTCAAGACATCATGATTCCTGGTAACCGAATGCTGATGGTCATTTTATTATGCCAAGTCCTGCTCGGAGGCACTAACCATGCCAGCCTCATACCTGACACGGGCAAGAAGAAAGTAGCGGCCGACATTCAGGGGGGTCGGAGGTCCGCTCAGGGCCATGAGCTCTTGCGGGATTTCGAGGTGACGCTGCTGCAGATGTTCGGCCTCGGCAAGCGGCCGCAGCCCAGTAAGGATGTGGTGGTGCCCGCGTATATGCGCGACCTGTACAGGCTTCAGTCGGCGGAGGAAGAGGATGAGCTGCACGATATCAGCATGGAGTATCCTGAGAGACCGACCAGCCGCGCCAACACTGTGAGGAGCTTCCATCACGAGGAGCATTTGGAGAATCTACCAAGCACAGCAGAAAATGGAAATTTCCGTTTTGTGTTCAACCTCAGCAGCATTCCAGAGAATGAGGTGATTTCTTCAGCAGAACTGAGACTCTATAGAGAACAAATAGACCATGGTCCAGCGTGGGATGAGGGTTTCCACCGGATAAATATATATGAAGTTATGAAACCCATAGCTGCAAATGGACTCATGATAAATAGGCTGCTGGACACGAGACTAATCCACCACAATGTGACACAGTGGGAAAGTTTTGATGTAAGCCCTGCAATTATGAGGTGGACCCGGGATAAACAGATAAACCATGGGCTTGCCATTGAGGTCATTCACCTCAACCAAACCAAAACTCATCAGGGGAAGCATGTACGGATAAGTCGATCATTATTACCTCAAGAGGATGCAGACTGGTCGCAGATGAGACCACTTTTAATTACATTCAGCCATGATGGCAGGGGACATGCACTGACCAGGAGGTCAAAAAGAAGTCCAAAACAGCAGAGACCCCGTAAAAAAAACAAACATTGCCGGAGGCATTCTCTTTATGTGGATTTCAGCGATGTGGGCTGGAATGACTGGATTGTGGCACCTCCTGGATACCAGGCCTTTTACTGCCATGGAGATTGTCCATTTCCCTTGGCTGATCACCTAAACTCAACTAACCATGCTATTGTACAAACTCTGGTAAACTCTGTTAACGCAAGCATCCCAAAAGCGTGTTGCGTCCCCACAGAACTGAGTGCTATCTCCATGCTTTATTTGGACGAATATGACAAAGTCGTCCTTAAAAACTACCAGGAGATGGTGGTGGAAGGGTGTGGGTGCCGTTGAGTCTGAGATCCAAACAATAAACTGTTAAGGGCTGGACTTCTTTCCACTGAACATTCACCTTGACCTTATTTATGACTTTTATGTGCAAAAGTTTTGACAATATGATCATATATTTTGACAAAATATATTTATAACTACGTATTAAAAGAAAAAAAAATAAAATAAGTCATTATTTT
Protein		Refseq >NP_001017034\|bone morphogenetic protein 4 [Xenopus (Silurana) tropicalis] MIPGNRMLMVILLCQVLLGGTNHASLIPETGKKKVVAEIQGGRRSAQSNELLRDFEVTLLQMFGLRKRPQPSKDVVVPAYMRDLYRLQSAEEEDELHDISMEYPERPTSRANTVRSFHHEEHLENLPSTAENGNFRFVFNLSSIPENEVISSAELRLYREQIDHGPAWEEGFHRINIYEVMKPITASGHMISRLLDTRLIHHNVTQWESFDVSPAIIRWTRDKQINHGLAIEVVHLNQTKTYQGKHVRISRSLLPQEDADWSQMRPLLITFSHDGRGHALTRRSKRSPKQQRPRKKNKHCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTDLSAISMLYLDEYDKVVLKNYQEMVVEGCGCR	Refseq >NP_001081501\|bone morphogenetic protein 4 [Xenopus laevis] MIPGNRMLMVILLCQVLLGGTNHASLIPDTGKKKVAADIQGGRRSAQGHELLRDFEVTLLQMFGLGKRPQPSKDVVVPAYMRDLYRLQSAEEEDELHDISMEYPERPTSRANTVRSFHHEEHLENLPSTAENGNFRFVFNLSSIPENEVISSAELRLYREQIDHGPAWDEGFHRINIYEVMKPIAANGLMINRLLDTRLIHHNVTQWESFDVSPAIMRWTRDKQINHGLAIEVIHLNQTKTHQGKHVRISRSLLPQEDADWSQMRPLLITFSHDGRGHALTRRSKRSPKQQRPRKKNKHCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNASIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR

Genomic

tropicalis

Genome Browser

Synteny

Xenbase G-Browse

GBrowse

Expression		tropicalis	laevis
UniGene		Str.490	Xl.4619
Gurdon EST/FL		XZT65619	IMAGE:4173707-IMAGp
Affymetrix 1.0		Str.26831.1.S1_s_at [+] Str.490.1.S2_at
GEO data			GEO

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene	BMP4	OMIM:607932
mouse		MGI	Bmp4	All(13) Targeted, knock Out(3) Targeted, other(10)
zebrafish		ZFIN	bmp4	11 Lines(s)

Publications
First:		Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse. [Development 1991]
Most recent:		ZFP423 coordinates Notch and BMP signaling, selectively upregulating Hes5 gene expression. [J Biol Chem 2010]
		View All Papers 37 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		growth factor activity
Biological:		growth
Cellular Component:
EC:
KOG:		[T] Transforming growth factor beta, bone morphogenetic protein and related proteins

Suppliers		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice	geneservice
		RZPD imagenes	RZPD imagenes

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