Gene Symbol: pdx1 Gene Name: pancreatic and duodenal homeobox 1 Synonyms: ipf1, XlHbox8, pdx-1 Add Xenopus synonyms Gene Function: homeodomain transcription factor Interactants: ins(17) , hhex(13) , gcg(10) , ptf1a(9) , unnamed(8) , sst(7) , fabp2(6) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		NCBI Nucleotide >XM_002934019|PREDICTED: Xenopus (Silurana) tropicalis homeobox protein 8-like (LOC100490648), mRNA GCCATGAACACCGATGACCAATATTATCCCCAAGCTCCACTTTACAAAGAGCCTTGTGCGTTCCAGAGGAGTCAGGCGCAGGACTATAACCCAAGCCCCCCAGCATGCCTTTACATGGGAAGGCAGCAGCAAGCAGCCTACAGCAACCCCTTGGTAGCTCTGGACCCCGGCAGTCCTCCAGACATCTCACCGTATGAAGTGCCGCCCATATCCGAAGAGCCCATTGTTCCTCACCTCCATCACCATCACCACCATCATCACCACCATCACCCAGGGATCCCTCACCCCCACCAGCAAATGCCATTCCCAGATGACACTGAATCTGCAACATTAGAGGAACGGAATCGAACCCTTTTACCTTTCCCATGGATGAAATCTACCAAATCCCACACCTGGAAAGGACAGTGGACAGGTGGATCATACATAATGGAACAAGAGGAGAACAAAAGAACAAGGACAGCCTACACAAGAGCCCAGCTGCTGGAGCTAGAGAAGGAGTTCCTCTTCAACAAATACATCTCGAGACCACGGAGAGTAGAGCTGGCAGTCATGCTGAACCTGACAGAGAGACACATAAAAATCTGGTTCCAGAACCGAAGAATGAAGTGGAAGAAGGAGGAAGATAAAAAGAGAGGAAGGGGCAGCGACCCAGAACAAGACTCTGTTGTGTCCTCTGCTGATGTGATTAAAGATGAGCCTCAATGTCTTGGAAACTCCCAAAACACAGGGGACTTGGTCCGTTCTTCTGCTCTGCCAACTTCGCCCCAGTCCAATCCCATTCCCGCTACCGGATCCTTGCGGCAGGCAGAAAAACGATAGAAATAGCCAAGAAAATGAAATGCTGGCCCAGTTCGTATTGTCTCACAAGTATTATGGAGATCAACTTTTCATGGACACAATAGACCATAAAATGAAATACAACCACTTATAGAATGAGCCCTCTTCTTTTGCCAATTAACAGCAACAAAAAAAATGTTTTTTCTCCTTGTACAATAGTAATTACTATTATATTGTTTTAGGTGCAAATATTCAGACTCCGATCTTAGAAAGTATTGAATGTTCTTTATTCATTGCATAGTACAGTGTGCTAGCATAGAGGCGTTATTTTTATGACATTGCAAATTATTTGTAAGATATTCTAGAATTGTACCAACATGTGAAGGGTTATTAGGGGTACAAAAACCATATGATTGTCAGCAAAAATGGACTGGCCCATCATAATACTTTTTGAGATATATAATGACAAAATTACATGATATGTTAGGCCAGAATTTTTATATAAATATATATATATATGTATATGTATGTATATATATATATATATATATATGTATGTATGTATA	Refseq >NM_001172211|Xenopus laevis pancreatic and duodenal homeobox 1 (pdx1), mRNA ATGAATGCTGATGACCAATATTATCCACAAGCTCCAATTTACAAAGAGCCCTGTGCGTTCCAGAGGAGCCAGGGACAGGACTATAACCCAAGCCCCCCAGCATGCCTTTACATGGGAAGGCAGCAGCAGGCAGCCTACAGCAACCCCTTGGTAGCTCTGGACCCAGGCAGTCCTCCAGACATCTCACCGTATGAAGTGCCTCCCATATCTGAAGAGCCCATTGTTCCTCACCTCCATCACCATCACTACCATCATCACCACCATCACCCAGGGATCCCTCATCCCCACCACCAAATGCCATTCCCAGATGACAACGAATCCGGAACCTTAGAGGAAAGGAACCGAACCCTTTTACCTTTCCCATGGATGAAATCCACCAAATCCCACACCTGGAAAGGACAGTGGACAGATGGATCATACATAATGGAACAAGAGGAGAACAAAAGAACAAGGACAGCCTACACAAGAGCCCAGCTGCTGGAACTAGAGAAGGAATTCCTCTTCAACAAATACATCTCTCGACCAAGGAGAGTAGAGCTGGCAGTCATGCTGAACCTGACAGAGAGACACATAAAAATCTGGTTCCAGAATCGGAGAATGAAGTGGAAGAAGGAGGAAGATAAAAAGAGAGGAAGAGGCAGTGACCCAGAACAAGACTCTGTTGTGTCCTCTGCAGATGTGCTAAAAGATGAGCCTCAATGTCTTGGAAACTCCCAAAAGACAGGGGACTTGGTCCTTTCTTCTCCTCTGCCAACTTCATCCCAGCCCAATCAAGTTCCTTCTATTGGGTCGCTGAGGCAGGCAGAAAAACGATAA
Protein		NCBI Protein >XP_002934065|PREDICTED: homeobox protein 8-like [Xenopus (Silurana) tropicalis] MNTDDQYYPQAPLYKEPCAFQRSQAQDYNPSPPACLYMGRQQQAAYSNPLVALDPGSPPDISPYEVPPISEEPIVPHLHHHHHHHHHHHPGIPHPHQQMPFPDDTESATLEERNRTLLPFPWMKSTKSHTWKGQWTGGSYIMEQEENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEEDKKRGRGSDPEQDSVVSSADVIKDEPQCLGNSQNTGDLVRSSALPTSPQSNPIPATGSLRQAEKR	Refseq >NP_001165682|pancreas/duodenum homeobox protein 1 [Xenopus laevis] MNADDQYYPQAPIYKEPCAFQRSQGQDYNPSPPACLYMGRQQQAAYSNPLVALDPGSPPDISPYEVPPISEEPIVPHLHHHHYHHHHHHPGIPHPHHQMPFPDDNESGTLEERNRTLLPFPWMKSTKSHTWKGQWTDGSYIMEQEENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEEDKKRGRGSDPEQDSVVSSADVLKDEPQCLGNSQKTGDLVLSSPLPTSSQPNQVPSIGSLRQAEKR UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene			Xl.85737
Unigene EST Profile			EST Profile
GEO data			GEO
Images		22 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	PDX1	OMIM:125853 OMIM:260370
mouse		MGI	Pdx1	All(13) Targeted, knock Out(3) Targeted, other(8)
zebrafish		ZFIN	pdx1	3 Lines(s)

Publications
First:		IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene. [EMBO J 1994]
Most recent:		Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in Xenopus. [Development 2012]
		View All Papers 7 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		DNA binding transcription factor activity
Biological:		regulation of transcription, DNA-dependent
Cellular Component:		nucleus
EC:
KOG:		[R] Transcription factor zerknullt and related HOX domain proteins

Reagents		tropicalis	laevis
Clones			EXRC - 1 clone(s)
			open biosystems
			geneservice/RZPD imagenes
Affymetrix 1.0		Str.51687.1.S1_at
Affymetrix 2.0

Symbol legend[+]

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