tp53 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Summary

Gene Literature (114)

Interactants (141)

XB-GENEPAGE-484285

Gene Symbol: tp53 Gene Name: tumor protein p53 Synonyms: mgc75630, mgc79985, p53, Xp53, Li-Fraumeni syndrome Add Xenopus synonyms Gene Function: transcription factor regulating cell cycle, apoptosis and TGF-beta signaling Interactants: mdm2(12) , cdkn1a(11) , atm(6) , myc(6) , tp63(6) , aurka(5) , ccnb1(5) View All

XB-GENE-484286

XB-GENE-6252168

Molecules		tropicalis	laevis
Gene		JGI XT Genome 4.1 Ensembl
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_001001903\|Xenopus (Silurana) tropicalis tumor protein p53 (tp53), mRNA GCCGAGAGGAACGGACCGGATAGAAACAGAGCGACCGATTCTTGTTCCGTTACCGACACTTTCCGGCCTGTGATCTGGTTCTGCCATGGAACCTTCTTCTGAGACCGGCATGGAGCCGCCCCTCAGCCAGGAGACCTTCGAGGATTTGTGGAGCCTGTTGCCGGACCCCCTACAGACCGGGACAGGTCAGATGGAAAACTTTGCGGAGTTTTCAGAGTACCCCCTGGCGCCAGACATGACGGTTCTGCAGGAAGGGCTTATGGGTAATACCGTGCCCACCGTGACTTCGTCTGCTGTCCCCTCAACTGAGGATTACGCAGGGAGCTACGGGCTCAAATTGGAGTTCCAACAGAATGGAACCGCAAAGTCTGTTACCTGCACATACTCCACCGACCTCAACAAGCTCTTCTGCCAATTGGCCAAGACCTGCCCTTTGCTGGTCCGTGTGGAGAGACCCCCGCCGCTCGGCTCCATTCTCCGGGCTACGGCCGTGTACAAGAAATCCGAGCACGTGGCCGAGGTGGTCAAGAGGTGCCCCCACCATGAGCGCAGCGTGGAGCCAGGGGATGACCCTGCCCCTCCCAGTCACCTGATGCGCGTGGAGGGAAATTCAAAGGCTTATTATATGGAGGATGTTGGTACCGGGCGCCATAGTGTCTGTGTGCCCTATGAGGGCCCTCAGGTCGGAACCGAATGTACCACCGTTCTGTACAACTATATGTGTAACAGCTCGTGTATGGGTGGGATGAACCGCCGGCCCATTCTCACTATTATCACCCTGGAGTCCCCAGAGGGGCTGCTGCTTGGCCGCCGCTGCTTTGAGGTTCGTGTGTGCGCCTGCCCCGGGAGGGATCGTCGCACAGAAGAAGATAATTGCACAAAGAAACGGGGCCTGAAACCCAACGGGAAGAGAGAGCTTTCTCACCCACCATCCAGTGACCCTCCACTTCCCAAGAAGCGCCTTGTTGAGGAGGATGATGAAGAGACCTTCACCTTGCTGATTAAGGGGCGGAGCCGCTATGAGATGATAAAGAAACTGAATGACGCACTTGAATTACAAGAGAGCCTCGACCAGCAGAAACTGTCCATAAAGTGCCGCAAGTGCCGGGACGAGATCAAACCCAAGAAAGGGAAGAAGCTGCTGGTGAAAGATGAGCTGCAGGACTCCGAGTGAGACCCCGACGGGAGCCAGCACTTGGGGGGCATCGGTGGCCGGTTCTCCGACTTTTGTTTTTTTTGTTTTGTTTTTTTTTTAAGCTCTGTCCCTCCTTTTAGCTAGTTTAGAGGGTCCGCATTGCCCTTGGGGGGCCCGCTAGTTCTATATGGCACCCAATATTATCCAGTCATTATGTGTTTGGGGGCTCAATTACACTGTTTACTCTGTATCATTGTAAGAGATGGGGGTACACCCCCCCACCCTGATAATGCATTTAAGGAAAATGAATGTCATATTGTTGTGGCCCACGAACAAAGTACCAAGGTCCCCCTGGCCCGCCCAGTCTGTGGTTCCAGTGCATTATGGGGCACTGGGTCAGGCTGTGTGGGTCACCCAATCAGTGAGGTGGCACCCCACTTGGGTAAAGGGAGGGCCTCTACTCCTGCCAACCTGTTAGTCATTGACTCCTGTAAGGAGGAGCTAATGCAGTGGGGGAGGGGCTTAAGGACAGGCAAAATAGTTCCCTTTCCATTGGCCAAAGTGATGGTGTTGGCCCTTACTGGGGCTGAATCCCATAATGCATCTGTAGGGCTCGGGACGGCCCAGTGTACGCATCAGAGGGTGGAGCTTCCTGCAGATTGAGTTGAATTCCCCCTTGAGTGGGGAATGTATTGGAGTGGGATAGGCCCCGCCCATCCAGGGTTCTGCTGACTGCCACCTTATTATGTAACCCTGTGGGTGAGGGTGTGAATGGTATGTGCCCAGTGTGGGAGGGATATAACTGCCACTCCTACCCCCCCATACAGACTCTCCTGGCATGCCAGCATGGTGGGCACTGTATGGGTTCATTGCTGCTCCGGTGTAGTGGCACCTATGCCTCTGGGGGTGCTAGAGAGCTCAGGGAGTTTCCCAGGCAGGGGCAATAAGAGGCCCGGGGGGTAAGATTTAGGCTCTGAAGGGCAGTTATATCGACATTTCATGGAGATTAGCGCCACATTTCCTCCCTTCAGCGCCAAATGGGTTATGGGCATCAATGGGTTATGGGCATCATTATTCGGTTGCTGGGGCTCCCCCAGATCTGCCCCTGTCTCCCCCCCCAAATGTGCCCCTGTCTCCCCATAACCTTCCTTTTTACTAACACTCACTGCCAATGAATTTTGTATCTTCTTTTTTTAATAAAAAAAATCCAGTAATCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA	Refseq >NM_001088098\|Xenopus laevis tumor protein p53 (tp53), mRNA GGAATTCCGCCCCGACTCGAGGAAGCAGAGAGGATAGAATCAGAGTCGCCATTTCTTTGGTTCCCGTTACCGGTCCTTTGCAGCGAGCCACCCCTCTGCTGCCTCCATAATGGAACCTTCCTCTGAGACCGGCATGGACCCCCCCCTCAGCCAGGAGACATTCGAGGATCTGTGGAGTCTGTTGCCTGACCCCCTGCAGACTGTCACGTGTCGGCTGGACAACCTATCAGAGTTTCCAGACTATCCCCTGGCAGCAGACATGACGGTCCTACAGGAGGGGCTTATGGGTAATGCTGTTCCCACCGTCACTTCATGTGCTGTCCCCTCAACTGACGATTATGCTGGGAAGTATGGGCTCCAACTGGACTTCCAACAGAACGGCACCGCAAAGTCTGTTACCTGCACGTATTCCCCAGAGCTCAACAAACTCTTCTGCCAGTTGGCCAAGACTTGCCCTTTGCTGGTGCGTGTGGAGAGCCCCCCGCCTCGCGGCTCCATTCTCCGGGCTACGGCCGTCTACAAGAAATCTGAGCATGTGGCCGAGGTGGTGAAGAGATGCCCCCACCATGAGCGCAGTGTGGAGCCAGGGGAGGATGCTGCGCCTCCCAGTCACCTGATGCGAGTGGAGGGAAATCTCCAGGCTTATTATATGGAGGATGTAAATAGCGGGCGCCATAGTGTCTGTGTTCCCTATGAGGGGCCTCAGGTTGGAACGGAATGTACAACAGTTCTGTACAATTATATGTGTAACAGCTCCTGTATGGGAGGGATGAACCGCCGGCCCATTCTCACCATCATCACCCTCGAGACCCCACAGGGGCTACTTCTTGGCCGCCGCTGTTTTGAGGTTCGAGTGTGTGCCTGCCCAGGGAGGGATCGTCGCACAGAGGAAGACAATTACACAAAAAAGAGGGGCCTGAAACCCAGCGGCAAGAGAGAACTTGCTCACCCACCATCCAGTGAACCACCACTTCCTAAGAAGCGTCTTGTTGTTGTTGATGATGATGAAGAAATCTTCACTTTGCGGATTAAGGGGCGCAGCCGCTATGAGATGATTAAGAAACTGAATGACGCACTTGAATTACAAGAAAGCCTCGATCAGCAGAAAGTGACCATTAAGTGCCGCAAGTGCCGGGATGAAATCAAACCCAAGAAAGGAAAGAAGCTGCTGGTTAAAGATGAACAGCCCGACTCGGAATGAGGACCCCGAATGAATGTAACGAACAGTTAGGGGGGATATCGGTGGCCGGTTCTCCGATCGTTTTGTTTTCTTTAAACTGCCTCCCTCCTTTTAGTTAGTTTAGAGGTTCAGTATTGCCTGTTTCATGTAGCACCCAATATGTTTATCCAGTTAGTCATTATGGGTTGGAGGCTCCATTACACCCTTTATGGGTTCACTGTAAGATATGGGGGTACACGCTCTCCCCCTATAATGTATTTAAGGGAAACAAATGTCATATCAGGATTGTTGTACAATTAAAGGCACATGAACCCTGTCTGAGCAGAAACAAAGCAATAGGGCCCCCGACCCACCGTGTCTCTGGTTCCAGTGCATTATGGGAAGCCTGTACTTTATGGACTGGTACCCAGTCACTGTGTGGGTGGGGCTTGTCTCTTCCTCAGGGAAAGTCAAACCCTCTACGCCTGCCCCTCCTGGAGGCGGAGTAAATGCAGTGGGGGAGGGGCTTCGATTCAATTCCACTGGCCAAGGAGCTGATTATGGGACGGTGAGAAGGAGGTAGGTGGGAAACCGGCTCTTACTGGGCTTCAGTCCCATAATGCATCTGTGTGTGGGACAACCAGTTATTTATTTGGGCTAGCTGCAGGCTTTTTATTATGTGACCCTATTTGTGAGGATATGAATGAGCCCTGCTGTGGCCAGTTTGGGAGGGGTAATAGTGCCCTCCAGCCATAGCACTGGGTGAGCCATACACAGAATGAGTTGGTCGCTCCCTGCATGTGGGGGGGGCAGTTGTATTTCCCTCCTCCAACACGGGTTATGCACATTGTAAATTCTCAATCAGGTTCCAGATAAAATTCTCTGATCATTCTTCAACTGCTGGGGCTCCCCCAAATCTGCCCCTGTCTCCCCCAATACTTCCTTTGTACTAACACTCACTGCCATCCAAATTTTGTATTTTTCTTTTTTTAATAAAAATTCTATTAATCTATAAAAAAAAAAAAACGAATTC
Protein		Refseq >NP_001001903\|tumor protein p53 [Xenopus (Silurana) tropicalis] MEPSSETGMEPPLSQETFEDLWSLLPDPLQTGTGQMENFAEFSEYPLAPDMTVLQEGLMGNTVPTVTSSAVPSTEDYAGSYGLKLEFQQNGTAKSVTCTYSTDLNKLFCQLAKTCPLLVRVERPPPLGSILRATAVYKKSEHVAEVVKRCPHHERSVEPGDDPAPPSHLMRVEGNSKAYYMEDVGTGRHSVCVPYEGPQVGTECTTVLYNYMCNSSCMGGMNRRPILTIITLESPEGLLLGRRCFEVRVCACPGRDRRTEEDNCTKKRGLKPNGKRELSHPPSSDPPLPKKRLVEEDDEETFTLLIKGRSRYEMIKKLNDALELQESLDQQKLSIKCRKCRDEIKPKKGKKLLVKDELQDSE	Refseq >NP_001081567\|cellular tumor antigen p53 [Xenopus laevis] MEPSSETGMDPPLSQETFEDLWSLLPDPLQTVTCRLDNLSEFPDYPLAADMTVLQEGLMGNAVPTVTSCAVPSTDDYAGKYGLQLDFQQNGTAKSVTCTYSPELNKLFCQLAKTCPLLVRVESPPPRGSILRATAVYKKSEHVAEVVKRCPHHERSVEPGEDAAPPSHLMRVEGNLQAYYMEDVNSGRHSVCVPYEGPQVGTECTTVLYNYMCNSSCMGGMNRRPILTIITLETPQGLLLGRRCFEVRVCACPGRDRRTEEDNYTKKRGLKPSGKRELAHPPSSEPPLPKKRLVVVDDDEEIFTLRIKGRSRYEMIKKLNDALELQESLDQQKVTIKCRKCRDEIKPKKGKKLLVKDEQPDSE UniProtKB

Genomic

tropicalis

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Synteny

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GBrowse

Expression		tropicalis	laevis
UniGene		Str.11712	Xl.394
Gurdon EST/FL		TTpA012j03	IMAGE:5085038
Affymetrix 1.0		Str.6676.1.S1_at	Xl.394.1.S1_at
GEO data			GEO

Phenotype		tropicalis	laevis
Smith Morpholino Screen		tneu034a23

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene	TP53	OMIM:114550 OMIM:114500 OMIM:202300 OMIM:114480 OMIM:151623 OMIM:161550 OMIM:260350
mouse		MGI	Trp53	All(55) Targeted, knock Out(9) Targeted, other(44) Chemically Induced(2)
zebrafish		ZFIN	tp53	28 Lines(s)

Publications
First:		Cloning and characterization of a cDNA from Xenopus laevis coding for a protein homologous to human and murine p53. [Oncogene 1987]
Most recent:		Expression of Targeting Protein for Xenopus Kinesin-like Protein 2 is Associated with Progression of Human Malignant Astrocytoma. [Brain Res 2010]
		View All Papers 5 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		DNA binding transcription factor activity
Biological:		regulation of transcription, DNA-dependent
Cellular Component:		nucleus
EC:
KOG:

Suppliers		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice	geneservice
		RZPD imagenes	RZPD imagenes

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