Gene Symbol: casp1 Gene Name: caspase 1, apoptosis-related cysteine peptidase Synonyms: ICE, interleukin-1beta-converting enzyme, xice, caspase 1, caspase-1 Add Xenopus synonyms Gene Function: apoptotic cysteine protease Interactants: bcl2(2) , casp2(2) , casp3(2) , amd1(1) , casp8(1) , casp9(1) , p2rx7(1) View All

Molecules		tropicalis	laevis a		laevis b
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene		Entrez Gene
mRNA		NCBI Nucleotide >XM_002935194|PREDICTED: Xenopus (Silurana) tropicalis caspase-1-A-like (LOC100491605), mRNA ATGGCAGCTCAGCTGAAAAAAGTGCGCAAACTCTTTATAGATGGATGTAATGCCGCAATTATCAACAATTTACTAGATGATTTGCTGGATAAAAGTGTACTAACAGATTCTGAAGTGGAGTACATCAATGAGTGCAATGCCATAACCAAGGACAGATGCCGGCGTATGATTGACAATATAAAGAATAAAGGAGATTATTCTAGCAACATTCTTCTTCAGTGCTTGGTGGAGAATCACAAGACGCTGGCCAAAAACATGGGACTTGATGCTCAGCTGAAAAAAGTGCGCAAACTCTTTATAGATGGATGTAATGCCGCAATTATCAACAATTTACTAGATGATTTGCTGGATAAAAGTGTACTAACAGATTCTGAAGTGGAGTACATCAATGAGTGCAATGCCATAACCAAGGACAGATGCCGGCGTATGATTGACAATATAAAGAATAAAGGAGATTATTCTAGCAACATTCTTCTTCAGTGCTTGGTGGAGAATCACAAGACGCTGGCCAAAAACATGGGACTTGATGTTTCAGAATCAGCTATTGCACCCCAACCCATACTAGAGCAGAATAAGAAGACAAATGAGAACACAGTTTCAGAACCTGCTATTGCACCCCAACCCATACAAGAGCAGAATAAGAAGACAAATGAGAACACAGAAATCAGCAGCGTGATTCATTGTTCGGATAAAGATTTCAAGGAAATTCATGACACTCAAGGAGATAAGATTTATGAAATGCGGAAGCGTGAAGGACGGAAGCGCTTCGCTCTAATCATCTGTAATGAAAAGTTTGAGACTCTGACTGAGCGCCAAGGGGCCAAGGTTGATCTGGATGGGATGACCAAATTACTAAATGAATTAGGATACCAAGTCCTTCAAGAAACAAACTTGGCAAAAGAGGAAATGCTGAAGGTGTTGAAGGAGTTTGCAGCCCGGGAGGAGCATGTGGATTCAGACAGCACCTTCATAGTACTGATGTCTCATGGAGATAAGCCAGGAGTCTGTGGGACAGACAGCAAGAAGATAGAACATGAAAAAGGACAGTGTCAGGTGACTAACCTGCTACAGACGGATGAAATTTTTTCTATATTCAACAATATCCATTGCCCGAAACTGCGGGACAAACCAAAAGTCATTATTATTCAGGCCTGCCGTGGGGAAGAAAGAGGCCAAAAATTAGTCTGTGATGCTGTGGCTTTGCCCCCAGAGGAACAATTGGAAGATGATGCACTCCATAGAGTTCAAAGAGAGACTGACTTCATTTGCTTCTGTTCTTCAACCCCAGATACTGTTTCTTGGAGACATCCTACCATGGGTTCCTTGTTCATCACAGGTCTGATTAAAAAAATGAATGAATTAGCCCATTGCCAGCCATTGATGGACATCTTCCTTGAAGTACAATCCTCGTTTAAGGGTCAAAGGCAGATGCCCACACAAGAGAGGAGTACGCTGACAAAGAAATTTTACCTTTTCCCAGGCCACTGATGTAAGGTATCAGTCAATGGATCCAAGAATATCAAGACCTTTGAATTTAGAATGTCTTTTTCTCTGCAGCAAGATAAGGTTGGGTGTTTACGGGTAACTCTTAAATCGTTTCAACATGATGATAGCGTCTAAATGGTTCTTTTTAACTGTGCCTTAAAGCAATGAGCAATATTAACAAATGTTAATTGCAAAAAGGTTTTATTGTGTAAAATAAATGTAACTAGAAGATG	Refseq >NM_001087754|Xenopus laevis caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) (casp1-a), mRNA TTTATCCTGTGTACATTATAGCTGCATTGCTGCTCGCCAGATATGACAGCTCAACTGAATAAAGTGCGCAGAGCCATTATAGATGGATGTAACCCTGCAATGATAAGTGATTTACTAGATGATTTGCGAGAAAAAAATGTACTTGTGGACTCCGAAGTGGAACACATCAAAGAGAGCAATAACACAAACAGGGACAGATGCCGGGCCATGATTGACAGTGTAAAGAAAAAAGGAGACGACCCAAGCAATATTCTACTTGAGAGCTTGGTGAAGAATCACAAAACTCTCGCCAAAAGCCTGGGACTCCACGAACCTCCTATGGCACCCGTGCCCATTCAAGAACATAATGCGGATACAATTAAGAACAAAGACATCAAAGGTGTAATTCCTTGTTCTGCTGAAGAATTCAAGAAAATTCAGGACACTCAAGGAGATAAGATTTATGATGTGCGGAAGCGTGAAGGACGGAAGGGCTTGGCTCTTATAATCTGCAATGAAAAGTTTGAGAATCTGAACGAGCGCCATGGAGCCAAGGTTGATCTGGATGGGATGACCAAATTACTAAATGAATTAGGATACCAAGTCCATCCACATACAAACTTGACAAAAACAGAAATGGTGAAGGTGATGAAGGAGTTTGCTGCCCAGGAGGAGCATGCAGATTCAGACAGCACCTTCATAGTTCTGATGTCTCATGGAGATAGGCAGGGAGTCTGTGGGACAGACAGCAAGAAGACAGAAAAAGAAAAAGGACAGTATGAGGTGACTAACCTGCTGGAGATCGATGAAATCTTTTCTACATTCAATAATGTCAATTGCTCTAAATTGCGGAACAAACCGAAAGTCATCATTATTCAGGCCTGCCGTGGGGAAAATAAAGGTGGATTATTAGTCCGTGATGATGTGGCTTCGCCCCCTCTGGAAGATGATGGGCTCCATTTTGTCCAGAGAGAGGCAGACTTTATATGCTTCTGTTCTTCAACTCCAGACACTGTTTCTTGGAGAGATCCTACAAAGGGTTCCGTGTTCATCACACATCTGATTGAGAAAATGAATGAATACGCTCATTGCCAACCACTGGGGGATATCTTTCTTGAAGTGCAGTCCTTGTTTAAGGATAAATGCCCAAACTCACGCTCACAGATGCCCACACAAGAGAGATGTACACTGACAAAGAAATTTTACCTTTTCCCAGGCTACTAATGTAAGGAATTAATGAATGGATTAAAGAACATCAAGAGCTTTTTGTTTAGGTTTTTTCCCTCTGCAGCAAAATGGGTTAAAGAAGAACTAAAGACTAACTAAAGATGATAGCCAGAAATGTTGTACATTATGTTTTGTGCTTCTGTACCAGCCCAAGGCAAACACAGCCCTTTAGCAGTAAGGATCTGTGTCTCCAAAGATGCCCCAGTAGCTCCTCATCTTCTTTTCTGCTGATTCACTGCACATGCTCTGTGCTGCTGTCACTTACTGAGCTTAGGGACCCACTTACAATATATAGTACACATAGAATATAATTGTCACAATATAAGGCTTTATTAATACAGATAATTACTACATCGCAGCTCAGAAACCAGTGCAATTAGCATCAGAATTTAACAATCAGCCCTGTAGCATCTGTTTATATTACAGACAAACCCCCCTAAGCCCCTAAGCTTAGCTTCTCAACAGCTGCTCAGAGCCCACCGAGTATGTGAAAGTCACAGACACTTTTCAAGATGGTGACCCCCTGTGACAAGTTTGAAGTTCTGGATCATTGCTGCTATTGACAAGCTGAAACTTTAGGCTGGTGCAATAAGTTCAGTATATAAAATATGGCATTTTTGGCCATATTCATTTTCAGGCTTTAGTTCTCCTGTAAGTGTTTAGGGGTGTCTCTTATTCCTTACAACATGACGGTAGCATTTAAACATTTTTACCACTGTGCCTTAAAATAATGAGCAATATTAAAATAAAAATACATTTTTAAAAAGAAAAAAAAAAAAAAAAAAAA		Refseq >NM_001085872|Xenopus laevis caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) (casp1-b), mRNA CTGAACGCAAGTAATTTATCCTGTGTATAATATAGCTGTCTTGCTACTCTAGATATGACAGCTCAGCTAAATAAAGTGCGTAAAGCCATTATAAATGGATGCAACCCTGCAATGATTAGTGATTTACTAGATGATTTGCAAGACAAACATGTACTTAAGGACTATGAAGTGGAACACATTAATAAGAAAAATAACACAAGCAGAGACAGATGCCGGGACATGATTGACAGTGTAAAGAAAAAAGGAGAGTACTCAAGCAACATTCTTCTTGAGAGCCTGGTGAAGAATCACAAAACACTGGCTGAAAGCCTGGGACTCCACGAACATGCACCGTCGCCCATTCAAGAACATAATGAGGATACAATTAAGGACAAAGAAATCAACAGTGTAATTCCTTGTTCTGCTGAAGAATTCAAGAACATTTATGACTCTCACGGAGATAAGATTTATGAAGTGCGGGAACGTGAAGGACGGAAGCGCTTGGCTCTTATAATCTGCAATGAAACGTTTCAGTCTATGAGTGAGCGTCGAGGGGCCAAGCTTGATCTGGAAGGGATGAACAAATTACTAAATGAATTAGGATACCAAGTCCAGCAACATACAAACTTGACAAAAGCGGAAATGGTGAAGGCAATGAAGGAGTTTGCAGCCCGGGAGGAGCATGCAGATTCAGACAGCACCTTCATAGTTTTGATGTCTCATGGAGATAAGCCGGGAGTCTGTGGGACGGACAGCAAGAAGACAGAAAATGGACAGTATGGGGTGACTAACCTGCTACAGGTGGATGAAATCTTTTCTACATTCAACAATGTTAATTGCTCTAGATTGTGGGACAAACCAAAAGTCATCATTATTCAGGCCTGCCGTGGGGAAAATCAAGGCGGAGAATTAGTCCGTGATGATGTGGCTCCGGCCCCTCTGGAAGATGATGCAGTCCATCATGTTCAAACAGAGACAGACTCCATATGCTTTTATTCTTCTACACCAGATACTGCTTCTTGGAGAAATCCTACAAAGGGTTCTGTGTTCATCATACGTCTGATTGAGAAAATGAATGAATTAGCTCATTGTCAACCACTAGGCGACATATTTCTTGAAGTACAGTCCTCGTTTAAGGATAAATCCCCAAACCAATACTCACAGATGCCCACACAAGAGAGATCTACAATGACAAAGAAATTTTACCTTTTCCCAGGCTACTGACGTAAGGAATTAATGAACGGAATCAATAACATCAAGAGCTTTGAATTTAGATTTTTTTTTCCTCTGCAGCAAAATGGGTTAAGTGTTTTGGGGTGTCTCTAAAATCCTATCAACATGACGGTAGCGTCTTAAATCTTTTAAAACAATGAGTGATATTAAACAAAAATAAATGAAAAAAATGTAACTGTTTAAATAAATACAGTAACTAGAAAAAAAAAAAAAG
Protein		NCBI Protein >XP_002935240|PREDICTED: caspase-1-A-like [Xenopus (Silurana) tropicalis] MAAQLKKVRKLFIDGCNAAIINNLLDDLLDKSVLTDSEVEYINECNAITKDRCRRMIDNIKNKGDYSSNILLQCLVENHKTLAKNMGLDAQLKKVRKLFIDGCNAAIINNLLDDLLDKSVLTDSEVEYINECNAITKDRCRRMIDNIKNKGDYSSNILLQCLVENHKTLAKNMGLDVSESAIAPQPILEQNKKTNENTVSEPAIAPQPIQEQNKKTNENTEISSVIHCSDKDFKEIHDTQGDKIYEMRKREGRKRFALIICNEKFETLTERQGAKVDLDGMTKLLNELGYQVLQETNLAKEEMLKVLKEFAAREEHVDSDSTFIVLMSHGDKPGVCGTDSKKIEHEKGQCQVTNLLQTDEIFSIFNNIHCPKLRDKPKVIIIQACRGEERGQKLVCDAVALPPEEQLEDDALHRVQRETDFICFCSSTPDTVSWRHPTMGSLFITGLIKKMNELAHCQPLMDIFLEVQSSFKGQRQMPTQERSTLTKKFYLFPGH	Refseq >NP_001081223|caspase-1-A [Xenopus laevis] MTAQLNKVRRAIIDGCNPAMISDLLDDLREKNVLVDSEVEHIKESNNTNRDRCRAMIDSVKKKGDDPSNILLESLVKNHKTLAKSLGLHEPPMAPVPIQEHNADTIKNKDIKGVIPCSAEEFKKIQDTQGDKIYDVRKREGRKGLALIICNEKFENLNERHGAKVDLDGMTKLLNELGYQVHPHTNLTKTEMVKVMKEFAAQEEHADSDSTFIVLMSHGDRQGVCGTDSKKTEKEKGQYEVTNLLEIDEIFSTFNNVNCSKLRNKPKVIIIQACRGENKGGLLVRDDVASPPLEDDGLHFVQREADFICFCSSTPDTVSWRDPTKGSVFITHLIEKMNEYAHCQPLGDIFLEVQSLFKDKCPNSRSQMPTQERCTLTKKFYLFPGY UniProtKB		Refseq >NP_001079341|caspase-1-B [Xenopus laevis] MTAQLNKVRKAIINGCNPAMISDLLDDLQDKHVLKDYEVEHINKKNNTSRDRCRDMIDSVKKKGEYSSNILLESLVKNHKTLAESLGLHEHAPSPIQEHNEDTIKDKEINSVIPCSAEEFKNIYDSHGDKIYEVREREGRKRLALIICNETFQSMSERRGAKLDLEGMNKLLNELGYQVQQHTNLTKAEMVKAMKEFAAREEHADSDSTFIVLMSHGDKPGVCGTDSKKTENGQYGVTNLLQVDEIFSTFNNVNCSRLWDKPKVIIIQACRGENQGGELVRDDVAPAPLEDDAVHHVQTETDSICFYSSTPDTASWRNPTKGSVFIIRLIEKMNELAHCQPLGDIFLEVQSSFKDKSPNQYSQMPTQERSTMTKKFYLFPGY UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis a		laevis b
UniGene		Str.33645	Xl.126		Xl.138
Unigene EST Profile		EST Profile	EST Profile		EST Profile
GEO data			GEO		GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	CASP1
mouse		MGI	Casp1	All(6) Targeted, knock Out(2) Targeted, other(3)
zebrafish		ZFIN	caspb

Publications
First:		Bcl-2 regulates activation of apoptotic proteases in a cell-free system. [Curr Biol 1996]
Most recent:		Spontaneous formation of IpaB ion channels in host cell membranes reveals how Shigella induces pyroptosis in macrophages. [Cell Death Dis 2012]
		View All Papers

Functional Ontologies
GO: Molecular:		caspase activity caspase activity (obsolete GO:0004199) caspase-1 activity More[+] protein binding
Biological:		proteolysis regulation of apoptosis
Cellular Component:		intracellular
EC:		caspase-1
KOG:		[D] Caspase, apoptotic cysteine protease

Reagents		tropicalis	laevis a		laevis b
Clones		open biosystems	open biosystems		open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes		geneservice/RZPD imagenes
Affymetrix 1.0		Str.33645.1.A1_at	Xl.126.1.S1_at [+] Xl.126.1.S2_at		Xl.138.1.S1_at
Affymetrix 2.0			Xl2.126.1.S1_at		Xl2.138.1.S1_at

Symbol legend[+]

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