Gene Symbol: otp Gene Name: orthopedia homeobox Add Xenopus synonyms Gene Function: homeodomain transcription factor Interactants: dll4(3) , nkx2-1(3) , nkx2-2(3) , chrd(2) , isl1(2) , lhx1(2) , t(2) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene
mRNA		NCBI Nucleotide >XM_002940870|PREDICTED: Xenopus (Silurana) tropicalis homeobox protein orthopedia-like, transcript variant 1 (LOC100490162), mRNA ATGCTGTCTCACGCCGACCTCCTGGACGCCCGGATCGGAATGAAGGACGCGGCTGAGCTGCTGGGGCACCGAGAGGCGGTCAAGTGCCGCCTGGGGGTCGGAGTTTCGGACTCGGTGCACCCGGGGGATCTGGGCAGCAATGCCGACCAAGTGGAAGGTGCCACCCTACTGCCCGGGGAGGACATCACCACCGTGGGTTCCAATCAGTCCTCACTGGCGGTCAGCTCCAAAGACCCAGACAAACAGCAGCAACAGCCAAACCAGACAGGCCAGCAGCAGGGCCAGCAGCAGAGCCAGCAGAAACAGAAGCGCCACCGGACCCGCTTCACCCCGGCACAACTCAACGAGCTGGAGAGGAGCTTCGCCAAAACCCACTACCCTGATATATTCATGAGGGAAGAGCTGGCCTTACGGATCGGCCTCACGGAATCCCGAGTCCAGGTCTGGTTCCAGAACAGACGCGCTAAGTGGAAGAAGCGCAAGAAGACCACCAATGTGTTCCGCGCCCCCGGCACCCTCCTGCCCACCCCCGGATTGCCCCAGTTCCCATCAGCCGCGGCCGCGGCAGCAGCAGCGATGGGCGACAGTCTTTGTTCCTTCCATGCTAACGATACCCGCTGGGCTACAGCCGGCATGGGGGTGTCTCAGCTCCCACTCCCCCCCTCCCTGGGCAGGCAGCAGGCCATGGCGCAGTCTCTGTCTCAGTGCAGCCTAGCAGCCGGCCCCCCTCCCAGCTCCATGGGTTTGTCCAACATGGGTTCCAATGGCGCTGGGCTGCAGTCTCATCTATACCAGTCCGCCTTTCCCGGCATGATGCCCACCTCATTGCAGGGTGGAAACAACGGGTCCCCCCAGCTGTGCAGCTCCCCGGACAGCAGTGATGTTTGGAGGGGGACTAGCATTGCCTCCCTGCGCCGCAAAGCACTTGAGCACACAGTCTCTATGAGCTTTACTTAATATTTCACCCCCTTCTCCCATCATTCCCTTTCTCATCCTCACCCCTCCAGGCCCCCGAGTCCCCTCTGTCCGGCTCGGTAATTGGTGGGTAATGGAAGCCTGTAAGGTTAAGGGGTGCTCTTCACACTAGGGGCTCTAGCCTGAGACCCTCAGTGTTGGGGGCAAAGTCCTGGTAGTTAGAATGAAAGGCTGAATTCCTGCGGCCTATCCACTCTACCTTCCATCACTCACCCCCGACTCCCCTCAGCTTCCCAACTCCATCCATCCCACCCAGGGGGCTTACAAAAGAAATGCATTTTCGAAGCACAATTCTCACTTATATAGGTTGCCCCCAAATGGATTTCTTTTGTGCCAAATGCAATGAAATACGCTTCTGCCATTGAGGACACCCAACCCCTTTTGATAAACATTTTATTTAGGAACAAAATACAAATATTAGGTGTTATTTCTTTTTCTAGAGGCAAAAAGCACTTCCCCTTCTCTGCCGATCGCTTGGCAGTTTGCCTTTGTAGTCCCCAATGCATTGCAGGCAGAAGCCTCTTGCCCTGCGGGCCCGGCAGGAGAGAGAAGCCCAGGACGTGTATATTTCCAAGGCAGGACTTTGTACAGAGACCCAATCGGCTTTTCTGCATGTGCTGGTCCAATACAAGTACAGAGATCAGAAGCTATTTCTAAGAATGAAGACAATGTGAAATAGGATGTTCTGTGTAGATAAAGCATTCTTGTTATATACTGGTCAGTTTGTGAGTTGTTTTAACTTATTGTCTGTGCTTATTTATTGATTTTACGTTTTTCTTAAATGTCCCAGCGAAGATGAAAGCTATGATTTACAATTTTCTTGACAAGTTTATAACAATTTAATGTAAATGGATAAATAAAATCATTTTCAGTATGTGAT
Protein		NCBI Protein >XP_002940916|PREDICTED: homeobox protein orthopedia-like isoform 1 [Xenopus (Silurana) tropicalis] MLSHADLLDARIGMKDAAELLGHREAVKCRLGVGVSDSVHPGDLGSNADQVEGATLLPGEDITTVGSNQSSLAVSSKDPDKQQQQPNQTGQQQGQQQSQQKQKRHRTRFTPAQLNELERSFAKTHYPDIFMREELALRIGLTESRVQVWFQNRRAKWKKRKKTTNVFRAPGTLLPTPGLPQFPSAAAAAAAAMGDSLCSFHANDTRWATAGMGVSQLPLPPSLGRQQAMAQSLSQCSLAAGPPPSSMGLSNMGSNGAGLQSHLYQSAFPGMMPTSLQGGNNGSPQLCSSPDSSDVWRGTSIASLRRKALEHTVSMSFT

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		[+] Str.22013
Unigene EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	OTP
mouse		MGI	Otp	All(4) Targeted, other(3) Targeted, knock Out(1)
zebrafish		ZFIN ZFIN	otpb otpa	6 Lines(s) 10 Lines(s)

Publications
First:		Brachyury proteins regulate target genes through modular binding sites in a cooperative fashion. [Genes Dev 2002]
Most recent:		Characterization of the hypothalamus of Xenopus laevis during development. I. The alar regions. [J Comp Neurol 2013]
		View All Papers

Functional Ontologies
GO: Molecular:		DNA binding transcription factor activity
Biological:		multicellular organismal development regulation of transcription, DNA-dependent
Cellular Component:		nucleus
EC:
KOG:		[K] Transcription factor PTX1, contains HOX domain

Reagents		tropicalis	laevis
Clones
Affymetrix 1.0		StrJgi.5459.1.S1_at [+] StrEns.8589.1.S1_s_at
Affymetrix 2.0

Symbol legend[+]

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