Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (70) Nucleotides (45) Proteins (13) Interactants (285) Wiki
XB-GENEPAGE-485516

Gene Symbol: lef1

Gene Name: lymphoid enhancer-binding factor 1

Synonyms: xlef-1, lef-1, xlef1 Add Xenopus synonyms

Gene Function: HMG box transcription factor, wnt signaling

Interactants: tcf3(24) , tcf4(16) , tcf7l1(16) , tcf7(13) , wnt8a(13) , sia1(11) , dvl2(10) View All

Disease Associations:
 
  XB-GENE-485517 XB-GENE-865531
Molecules tropicalis laevis
Gene JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1 JGI XL Genome 6.0
Entrez Gene
Entrez Gene
mRNA NCBI Nucleotide Refseq
Protein NCBI Protein Refseq
Genomic tropicalis laevis
Genome Browser
GBrowse
tropicalis genome v7.1 gene model

GBrowse
laevis genome v6.0 gene model

Links
tropicalis 4.1 synteny Metazome
Expression tropicalis laevis
UniGene Str.10421 Xl.85523
Unigene EST Profile EST Profile EST Profile
GEO data GEO
Images 8 expression image(s) for tropicalis and laevis
Orthology
MOD Entrez Gene Genetic Phenotypes Morphants
human
OMIM:Gene, HGNC LEF1
mouse
MGI Lef1 All
zebrafish (a-gene b-gene)
ZFIN lef1 All
chicken
GEISHA LEF1
Publications
First: XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos. [Cell 1996]
Most recent: The Xenopus Tgfbi is required for embryogenesis through regulation of canonical Wnt signalling. [Dev Biol 2013]
View All Papers 11 paper(s) referencing morpholinos
Functional Ontologies
GO: Molecular: DNA binding
      Biological: regulation of transcription, DNA-dependent
      Cellular Component:
EC:
KOG: [K] Transcription factor TCF-4
Reagents tropicalis laevis
CRISPR / TALEN Design CRISPR / TALEN
Design CRISPR / TALEN
Clones   EXRC - 4 clone(s)  
Thermo Scientific Thermo Scientific
geneservice/RZPD imagenes geneservice/RZPD imagenes
Antibody
Affymetrix 1.0 Str.10421.2.A1_at [+] Xl.410.1.S1_at
Affymetrix 2.0 Xl2.410.1.S1_at

Symbol legend[+]

My Xenbase: [ Log-in / Register ]
version: [3.2.1]


Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556