Gene Symbol: mixer Gene Name: mix-like endodermal regulator Synonyms: tMixer Add Xenopus synonyms Gene Function: homeodomain transcription factor Interactants: sox17a(18) , t(17) , nodal(16) , sox17b.1(15) , vegt(14) , gsc(13) , sox17b.2(12) View All	1/2

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		NCBI Nucleotide >BC158433|Xenopus tropicalis cDNA clone IMAGE:6990945, partial cds GCACCGGTCATTTTGGGAGCCACAAGCCTTGGGAACCCAGGAAGCAGCCAGTCCCTAGGATGGACTCATTCAGCCAACAACTGGAGGACTTCTACCCTTCTTGCTTCTCTGCCAGGTCCAACCCAGCGGCCTTCCCTGACCCCCCGGCCCAGCACTTAGCTATGAGCCTTGGTACCGCTCAGAAGGATTTCCAAGAGGCCAGCTTAAAGGTACACGTCCATTCGGCCAATGATCATCAAACACCAGGGTCCCAGAAGCCCAACTCTCCGCCAAAGCAAGAAATGGTCTCCCCCGTATCTTCAGCTGATGTAACACTGGGGTCCCAGCGCCGCAAGAGAACATTCTACAGCCAGAACAAGCTGGATGTTCTAGAGCAGTTCTTCCAGACCAACATGTACCCAGACATCCACCAACGGGAAAACTTGGCTAAACGGATCTACATCCCAGAGTCCAGAGTTCAGGTCTGGTTCCAGAACAGAAGAGCAAAGGAGCGCCGCGACAAGTCCAAATCCAACCCCTCTGTCGGAATGTGCTACCCCAGTGTTCGACGCCCCAACAAAAACATGTACCCCTCCAACCCACCGCCAAACGTGGCTGTTTCCCAGCAGCACATGGGTTTCCCAAAAGCACAAGGCCAACTGTATATGAATTCCCAGCAGAATCAGTTCCAGCCGACTCAGGAGTCTCAACTTTGTCCAGAGTCCATCTATTCTGCCTCCCAGCAGAGGTTCCTGATGCAACAGGCTGCACACAGCAGCTACCATGGAATTCCTGCCTCTTATAAACCTACAGACACCCAGCAGCACTTGTACAGATACATGAGCCCAACAGGAGGCATCCAGGAGAAGGTGATGGACCTCAGCAAGAAGCACAGCCCCATGCCCTTTCATCCCAGCCTTCTAATGGACTTCAACAACTTCCCGCCCAACAAGACCATCACTCCAGATATGAATGTTATAATCCCACCCATTCCTGTCTCGGGAACTTCAAACAAGCACACTCGGATGAATGTCTTTGATAGCAAAGAGGCCTGCCCTATGGTGTCCATGCCAGAGGAGGTCTACGAGGAGTTCTCTCCAGTCTCAGATTCTGGCGTTAGTGATGGCTCTACTGTGTCTTTGACAGACTTTAAAGATAGTGATGGTTCTGTTCTTGACAACATGTAAACATGGAAAGAAAAGAGTTCACATTTCTAAGCCCCAAGCAAGGTGTCTCCTGTGTCATTAGGCTTTAAATTCGCCATATGGACCGATGGACTAACCAATAAGCCAAGTCTACGTTCTACTGATCTCCTGTGTCATTAGGCTTTACCTTGGCCATACGGACTGATGGACTAACCAATAAGCCAAGTCTACGTTCTACTGATCTCCTGTGTCATTAGGCTTTACCTTGGCCATACGGACTGATGGACTAACCAATAAGCCAAGTCTACGTTCTACTGATCTCTTGTGTCATTAGGCTTTACCTTGGCCATACGGACTGATGGACTAACCAGTAAGCCAAGTCTACGTTCTACGGATCTCTTGTGTCATTAGGCTTTACCTTGGCCATACGGACTGTTGGACTAACCAATAAGCCAAGTCTACGTTCTACTGATCTCTTGTGTCATTAGGCTCTATCTTGGCCATAAGGACTGATGGACTTACCAATAAGCCAAGTCTACTTTCTACTGATCTCTTGTATCATTAGGCTTTACCTTGGCCATATGGACCGATGGACTTACCAATAAGCCAAGTCTACTTTCTACTGATCTCTTGTATCATTAGGCTTTACCTTGGCCATATGGACCGATGGACTTACCAATAAGCCAAGTCTACTTCCTGCTGATATCTACTCTAGAGCCCCTTCTAGATTTTGTGCCCCCATGAACAGATAAATTTTTTTCACCAGCCATATTGTTTGCCCAAAGGGATAAGTGGTGATTTAGATGACCTGCCTATAGCTATAGTGCAACTGTACATTAGTCGGACCCACCCCTATATTTGTATTGTTACCCCCTGAGAGACCCCTAACCTCCCCCCTTTTCAGTAATGTACATTTTATATTTTGAATTTGAATTTTTTTATTTTTCCATGTAAAATATTTTTTTCAGAAGTGTTTTTGTTCCTTTATTTTCCCATTAAAATGTATTAATTATTCTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA	Refseq >NM_001088291|Xenopus laevis mix-like endodermal regulator (mixer), mRNA AGCAGCACTGGTCACTTTGGGAGCCACAAGATTTGGGAGTTCAAGCAGCAGCTAGCCCCTAGGATGGACACGTTCAGCCAACAACTGGAGGACTTCTACCCATCTTGCTTCTCTGCCAGGTCCAGCCCAGTGGGCTTCACTGATCCACCAGCCCAGCACTTAACCATGAGCCTTGGTGCCATTCAGAAGGATTTCCAAGAGTCCAGCTTAAAGGCAAACGTCCAGCCAGTCAGTGATCCTCAAACACTAGGGACCCAGAAGTCCACCCCTCCTACAAAACAAGAAATGGTCTCCCCGGTATCTTCAGTTGATGTGACATTGGGATCACAACGCCGCAAGAGAACATTTTACAGCCAGAACAAGCTGGATGTTCTAGAACAGTTCTTCCAGACCAACATGTATCCAGACATTCACCACCGGGAAGAACTGGCTAAACGGATTTACATCCCAGAGTCCAGAGTTCAGGTCTGGTTCCAGAACAGAAGAGCAAAGGAGCGCCGCGATAAAGCCAAATTAAACCCCTCGCCAGCAGTAGGCGTGTGCTACCCCAGTCTTCGACAACCCAATAAAAAAATGTACCCCTCCAACAACCCAACACCAAATGTGCCTGTTTCCCAGCAACACATGGTTTTCCAAAAACCACAGGGTCAACTGTTCATGAATTCCCAGCAGAATCCGTTCCAGCCAACTCAGGAATCTCAGCTTTGTTCAGAATCCATCTACGCTGTTTCCCAGCAGAGGATCCTGATGCAGCAGGCTGCACGGAGCAGCTACCATGGAATTTCAGCATCTTATAAACCTACAGACACTCAGCAGCACTTCTACTCATACATGAGCCCAATGGGAGGCACCCAGGAGAAAGTCATGGATCTAAGCAAGAAGCACAGTCAGATGCCCTTCCATCCCAGTCTTCTAATGGACTTCAACAACTTCCCTCCCAACAAGACCATCACTCCAGATATGAATGTTAGAATCCCACCAATTCCTGTCTCTTCACCGTCAAACAACCACAGTTGGATGAATGTCTTTAATACCAAAGAGGCCGGCCCATTGGTGTCCTTGCCAGAGGATGTCTATGAGGAATTCTCTCCGGTCTCTGATTCTGGTGTTAGTGATGGATCTACCATGTCTTTGACAGACTTTAAAGATAATGATGGATCTGTGCTTGACAACCTGTAAGATAAAGCAAGAGTAGTCATCTCTAAACCTCACGCTAGGTGTCTCCACCTCTTACCCAAAGAGACTGATGGACTTACTAATAAGCCAAGCCTAGTTTCTACCAATATCTCCGATACAAAAAAGAGCAGCCGAAATGTATTTGATTGTTCGATTCGAATTCAGATCATATTCGATCGAATTCGATTCGAAGGATTTTCTAAAAAAAAACTTTGATTTTTCAAAGTCAAATGACTCCAAATTAAAGAGACAGTACATGATAAATTTCGTATTTTCACATTTTCACATTTTCTTTGAATTTTAAAATTACATTTTTCAATTTGACCCTTGATAAATCTGCCCCATAGTGTTAAATGTGTGTTCAACTAAGATATAAACCCCCTCAGCTGTGCCCACAAATATCAAACAATTTTACTGGCCT
Protein		NCBI Protein >AAI58434|Unknown (protein for IMAGE:6990945) [Xenopus (Silurana) tropicalis] TGHFGSHKPWEPRKQPVPRMDSFSQQLEDFYPSCFSARSNPAAFPDPPAQHLAMSLGTAQKDFQEASLKVHVHSANDHQTPGSQKPNSPPKQEMVSPVSSADVTLGSQRRKRTFYSQNKLDVLEQFFQTNMYPDIHQRENLAKRIYIPESRVQVWFQNRRAKERRDKSKSNPSVGMCYPSVRRPNKNMYPSNPPPNVAVSQQHMGFPKAQGQLYMNSQQNQFQPTQESQLCPESIYSASQQRFLMQQAAHSSYHGIPASYKPTDTQQHLYRYMSPTGGIQEKVMDLSKKHSPMPFHPSLLMDFNNFPPNKTITPDMNVIIPPIPVSGTSNKHTRMNVFDSKEACPMVSMPEEVYEEFSPVSDSGVSDGSTVSLTDFKDSDGSVLDNM	Refseq >NP_001081760|mix-like endodermal regulator [Xenopus laevis] MDTFSQQLEDFYPSCFSARSSPVGFTDPPAQHLTMSLGAIQKDFQESSLKANVQPVSDPQTLGTQKSTPPTKQEMVSPVSSVDVTLGSQRRKRTFYSQNKLDVLEQFFQTNMYPDIHHREELAKRIYIPESRVQVWFQNRRAKERRDKAKLNPSPAVGVCYPSLRQPNKKMYPSNNPTPNVPVSQQHMVFQKPQGQLFMNSQQNPFQPTQESQLCSESIYAVSQQRILMQQAARSSYHGISASYKPTDTQQHFYSYMSPMGGTQEKVMDLSKKHSQMPFHPSLLMDFNNFPPNKTITPDMNVRIPPIPVSSPSNNHSWMNVFNTKEAGPLVSLPEDVYEEFSPVSDSGVSDGSTMSLTDFKDNDGSVLDNL

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.52723	Xl.291
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		19 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human
mouse
zebrafish

Publications
First:		Mixer, a homeobox gene required for endoderm development. [Science 1998]
Most recent:		The XenopusTGFBI is required for embryogenesis throughregulation of canonical Wnt signalling. [Dev Biol 2013]
		View All Papers 17 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		DNA binding transcription factor activity
Biological:		regulation of transcription, DNA-dependent
Cellular Component:		nucleus
EC:
KOG:		[K] Transcription factor PRD and related proteins, contain PAX and HOX domains

Reagents		tropicalis	laevis
Clones			EXRC - 1 clone(s)
		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.20300.1.S1_a_at	Xl.291.1.S1_at
Affymetrix 2.0			Xl2.291.1.S1_at

Symbol legend[+]

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