Gene Symbol: rasgrf1 Gene Name: Ras protein-specific guanine nucleotide-releasing factor 1 Synonyms: cdc25, GNRP Add Xenopus synonyms Gene Function: guanine nucleotide exchange factor Interactants: cdc25c(105) , cdk1(82) , pold1(61) , ccnb1.2(46) , mapk1(18) , cdk2(17) , plk1(17) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		NCBI Nucleotide >XM_002932963|PREDICTED: Xenopus (Silurana) tropicalis ras-specific guanine nucleotide-releasing factor 1-like (LOC100492267), mRNA ATGGGTAGGAGGAGTAAGGAAAACACAAATAGGAAGAAAGTAGACAAGGGTAGATATCACAAAGCAATTGTAGAGAGGAATGGAATAAAGTATTATTTTATCATCAACTTCAACCACGAGAACCAGAAACCTCTGGAGCTGAGGACAGAAGATGCCAAGGACTGTGAAGAGTGGGTGACCGCAATCTCACGAGCCAGCTACAAGACATTAGTGACTGAACATGAAGCTTTGATGCAAAAGTATTTGCATTTACTGCAGATTGTTGAGACGGAGAAGAAGGTGGCAAAACAGTTGCGGCAGCAGATAGAAGATGGAGAGGTAGAGGTGGAGCGTCTTAAATCTGAGATTGCATCATTATTGAAAGACAATGAACGCATCCAGTCAACACAAACTGCAGCCCCAAATGAGGATGTTGACATCAAAAAGATTAAAAAGGTACAGAGCTTCCTGCGTGGCTGGCTGTGCCGCAGGAAGTGGAAGAGCATTATCCAGGATTACTCGAGGTCTCCCCATGCAGACAGCATGCGGAAGAGGAATCAAGTTGTGTTCAGTATGCTGGAAGCCGAGGCTGAGTATGTGCAACAGTTACACATACTGGTCAATAATTTCCTGCGGCCACTTCGCATGGCTGCCAGCTCCAAAAAGCCTTCAATTACTCATGATGATGTCAGCAGCATTTTCCTCAACAGTGAAACCATCATGTTTTTGCACCAGATATTTTACCAAGGTCTGAAGGCTAGAATATCCAGCTGGCCCACACTGGTGCTGGCGGACCTGTTTGACATCCTTCTGCCAATGCTGAACATTTATCAGGAATTTGTGCGGAACCATCAGTACAGTCTGCAGATTCTGGCTCACTGCAAACAGAACCGGGATTTTGACAAACTGCTGAAACAATATGAAGCCAAACCAGACTGTGAGGAGCGGACGCTGGAAACCTTCCTCACATATCCCATGTTTCAGATTCCTCGATACATACTCACTCTACATGAACTGCTGGCTCATACACCTCATGAACATGTGGAGCGGAATAGTCTGGAATATGCTAAATCCAAACTGGAGGAGCTCTCACGAATTATGCACGATGAAGTCAGCGAAACCGAGAATATCCGGAAGAATCTGGCAATTGAGAGGATGATAGTTGAGGGGTGCGAAGTTTTACTGGACACCAGTCAGACATTTGTGCGGCAAGGCTGTCTCATCCAGGTCCCTATGTCAGAGAAGAGTAGGATAACAAGAGGACGCCTTGGTTCTCTGTCTCTGAGAAAGGAAGGAGAACGTCAGTGCTTTTTATTTTCCAAACACCTTCTGATCTGCACACGGAGCTCAGGGGGCAAGTTACATCTCACCAAGAACGGAGTGGTCTCGCTGATGGACTGCACTTTACTAGAAGAAAATGATGATGATGACAGTGAGTATCACCCAAAGCAACAAGATGGGGATCACTTAGACTTTAAAATCTCTGTGGAACCCAAAGATTCTGCACCATTTGTTGTCATTCTTCTTGCATCATCCAGACAGGAGAAAGCAGCCTGGACAAGTGACATAAGCCAGTGTGTGGACAACATCCGCTGCAATGGCCTTATGATGAATGCATTTGAGGAGAATTCCAAGGTTTCTGTTCCTCAGATGATCAAGTCTGACAGCAGTTTGTACTGTGATGATGTGGACATACGCTTTAGCAAGACCATGAATTCATGCAAGGTTCTCCAGATTCGCTATGCAAGTGTCGAACGCTTACTGGAACGTCTCACAGACTTGCGCTTCCTGAGCATCGATTTCCTCAACACGTTCTTGCACTCCTACCGGGTTTTCACCACTGCTGACATTGTACTGGAAAAGCTTATTGCTATTTACAGGAAGCCAGTCAGTGCTATCCCTGCCAGGTCCCTGGAGCTCCTGTTTGCTAGTAATCAGAATAACAAACTTCTATATGGGGAGCCCCCAAAATCTCCCAGAGCCACTCGCAAGTTTTCATCTCCACCACCTTTATCCATTACAAAGTCCTCATCACCAAGCCGCCGACGCAAACTCTCCCTCAACATTCCTATAATAACGGGAGGAAAAGCACTTGACCTTGCTGCTCTTGGGTGTTCCACCAATGGATACCAAAGTACTTGTCCTGCCCCTCCACCATACAGCAAGACTACTTTAGACATCAACAAACTCTATGTGTCTGGGAGCTTTCCCAGTAAGGTGGGGGAGGGAGAAGAACCTCCTGCAGAGAGGGATGAAGAACCAGGGACTCAGAGGCAGAACTCTGAAGTTTCCACCCGTGGAGATTCGGACAATGAGCAAACGGATGGTGACGAGGCTGAAACAGATACTTCTCCTACACGTTCTCCCACCACCCCAGTATCTCAGCGAGGCCGTAACTCTGCAGATTTCACACTCTTTTCATATAATAATGGCATTGTGATGACCGCCTGTCGGGAACATGATAACAGCCGAAGCAACCTATCAGCAGCTTCTGCCTTTGCTATAGCAACAGCTGGAGCCAATGAGGGAACACCAACAAAAGAGACCTACAGACGCATGTCTTTAGCCACTGCAGGGTTCCCCTCAGATCAAAGAAACGGAGACAAAGAATTTGTAATCAGAAGAGCAGCAACGAACCGAGTGCTGAATGTACTGAGACACTGGGTGTCCAAACATGCACAGGATTTTGAGACCAATCTGCAGCTAAAGACAAAGGTGATTTGTTTCCTGGAGGAGGTTATCCACAACCCTGAGTTGCTGGCTCAAGAGCGGAAGGCAGCAGCCAATATCATTCGCACATTGACCCAGGAGGATCCCGGAGACAGTCAGGTTACTTTGGAAGAAATTGAGAATATGGTATTGGATGGTCCAATGGAACTCTTTGAATCCCTGTCTGCATTGGAGATTGCAGAGCAACTCACATTATTGGATCACCTCATCTTCAAAAAAATCCCTTATGAAGAATTCTTTGGTCAAGGTTGGATGAAAAATGACAAGAATGAACGGACACCTTACATAATGAACACTAGCAAGCACTTCAACCTTATGAGTAATTTGATTGCCACTGAGATTCTGCGAGGGGAAGAGCCAGCACAGCGTGGATGTACCATAGAAAAGTGGGTTGCCGTAGCTGATATTTGTCGCTGTCTCCATAATTACAATGCTGTTTTGGAGATTACATCATCCCTAAACCGCAGTGCAATATACCGTCTCAAGAGGACTTGGATCAAGGTTTCCAAGCAGACAAAGACGTTAATTGACCGGTTACAAAAGCTGGTGTCTTCAGAAGGACGATTCAAGAATCTTAGGGAAGCTCTAAAGAATTGTGACCCACCATGTGTCCCTTATCTGGGCATGTACCTAACAGATCTGGCTTTTATAGAGGAAGGGACCCCAAATTACACAGAAGACGGACTGGTCAACTTCTCTAAGATGAGGATGATTTCACACATTATTCGAGAGATTCGGCAGTTTCAGCAGACTTCATACAAGATTGAACATCAGCCCAAGGTGACACAGTATCTCCTGGATTCTTCAACAGTGCTAGATGAAGAAGGTCTATATGAAGCTTCTCTCCGACTGGAGCCCAAACTCCCCACCTGAAAGTTTTTTTAGAACCCCCTGCCTGTATCATATTGTACAGAACCCCCCAAGCCTCTCGCCAGACCCCACTGTGCAGGGGTCACCAAGCAGGGGCAGAGATGTCTGTGTCTCCATCCATCCCAAAAACCCAATATCTCCTCCGAGACACCCCACACTGCCCCCCCCCAGGTTTGCCCCAAAGACACCCCACAGAGAAAGTGAGTAGGGTGGAGACTGAGATGCCTCTTACCAAAAGCCCTGTCTTACAGTCTCACAAACTATGC	NCBI Nucleotide >BC083032|Xenopus laevis hypothetical LOC494866, mRNA (cDNA clone IMAGE:5440362), partial cds GTCGACCCACGCGTCCGCTGGGAGTTTTCCCAGCAAGGTGGGGGAGGGAGAAGAACCGCCTGCAGAGAGGGATGAAGAACCAGGAACCCAGAGGCAGAACTCTGAAACTTCCACTCGTGGAGATTCGGACAACGAGCAGACAGATGGTGATGAGGCTGAAACAGATACATCCCCCACGCGTTCTCCCACCACTCCTGTATCTCAGCGTGGGCGCAACTCTGCAGATTTCACACTTTTCTCATATAATAACGGCATTGTCATGACTGCCTGTCGGGAACATGATAACAGCCGAAGCAACCTATCAGCAGCTTCTGCCTTTGCCATAGCAACAGCTGGAGCCAATGAGGGAACACCAAAGAAAGAGACATACAGGCGAATGTCTTTAGCCACTGCAGGATTCCCTTCAGATCAGAGGAATGGAGACAAAGAATTTGTGATCAGGAGAGCAGCAACGAACCGTGTGCTTAATGTACTGAGACACTGGGTGTCCAAACATGCACAGGATTTTGAGACAAACCTGCAGCTAAAGACTAAAGCGATTTGTTTCCTGGAGGAGGTTATCCATAACCCTGAGTTGCTGGCTCAGGAGCGGAAGGCGGCAGCCAATATCATTCGCACATTGACCCAGGAGGATCCCGGAGACAGTCAAGTTACCCTGGAAGAAATTGAGAATATGGTGTTGGATGGTCCAGTAGACCCCTTTGAATCTCTGTCTGCATTGGAGATTGCAGAGCAACTCACTTTACTGGATCACCTTATCTTCAAGAACATCCCATATGAGGAATTTTTTGGTCAAGGATGGATGAAAAATGACAAGAATGAACGGACACCTTACATAATGAACACTAGCAAACACTTCAACCTTATGAGCAATCTGATTGCCACAGAGATTTTGCGAGGGGACGAGCCAGCACAGCGTGGATGTACTATAGAAAAGTGGGTTGCAGTAGCCGATATTTGTCGCTGTCTCCATAATTACAATGCTGTTTTGGAGATCACATCATCCCTTAACCGCAGTGCGATTTACCGTCTCAAAAGGACCTGGATCAAGGTTTCCAAGCAGACAAAGACATTAATTGATCGGTTACAAAAACTGGTGTCTTCAGAAGGAAGATTCAAGAATCTTAGGGAGGCTTTAAAGAACTGTGACCCACCATGTGTCCCTTATCTGGGTATGTACCTGACAGATCTGGCTTTTATAGAGGAAGGAACCCCAAATTACACAGAGGATGGACTGGTCAACTTCTCTAAGATGAGGATGATTTCACACATTATTCGGGAAATTCGGCAGTTTCAGCAGACTTCATACAAGATTGAAAACCAGCCCAAGGTGACACAGTATCTCCTGGATACTTCAACAGTGCTAGATGAAGAGGGTCTTTATGAAGCTTCTCTCCGACTGGAGCCCAAACTTCCCACCTGAAGTTTTGTTTAGAACCCCTGCCTGTATCATATTGTACAGAACCCCCCAAGACTCTATCCAGACCCCACGATGCAGGGGTCACCAAGCAGGGGCAGAAATGTCTGTGTCTCATCCATCCCAAAACCCAATCACCTCCGAGACACCCCACACTGCCCCACCCCAGGTTTGCCCCAAAGACACCCCGCAGAGAAAATGAGTTCTTACTAGAAGCCCTGTCGTACAGCTTCATAAACTATGCAGTGGGAAGGCTTGGACTGCTAAAGCCTCCTTCTGACTTTTAGTGAGAGGAGTAATAATGGGAGAAACACATCACCCAAACAGTGGCCACCCTGCACTTGCATCCTCCATCACCTGTTATGCTAGAATGGAGGGGGGTGGAGCAATGATTCGCAGTCTTTCAGATCTTAACTGTGAGCTGTGCTTAATGCAAAATGAGTTTGGTGAAACTAGGAGACTTCGAAGAGAATACATGAAATGATGATGTCCCTATAAAAAATTAAGATATGAATTCTGCTTTGTTGCACAACAGAGAATTATCATGTTATATTGGAGTCTACTAAGCCTGCTTCTTATTTTTTCCATATCAAGAGCTGGCCAAGCTGGATACACAGATTCGGGAATCTGGTCATGATTTGTGGAATGGGAATCTGAGCAGCACCTCACAATATTGTTGTGATTATAAAGGCCTCACAGCTCGTTTTAATATAAGGGGCTGCTTGTGGTGGTTACTTTCAGCAATCTGAGCAGAGGAGAACCCAATAATGGATATAGCAGAAAGCACAGAACTGCACCAGAGGATATAGAGATGCTGGTATAGAGAAAGCAACTGTTTCCTGTGAATTTAAGTAAAGATTAAGGCTCCGTGATTTACTGTCATGAGTTATCTCCAACCATTGAGCTTCGCAGAAAAGAATATTATCAGCTGGAATATATAGATTAAGCACAAGGCATAGAATGAAGGCCCCTCCAGCAGCTGGTCTAGAGGACTGATGGTTTAGAGAAAAATTTGCAACTATATTTCTGGTATCTTTATTTTTTTTGTACAATTCAGTATTTCCTGATTACCTCTCGCTAATAAATCTTTTATCTCAGGGTTACCACCAAAAAAAAAAAAAAAAA
Protein		NCBI Protein >XP_002933009|PREDICTED: ras-specific guanine nucleotide-releasing factor 1-like [Xenopus (Silurana) tropicalis] MGRRSKENTNRKKVDKGRYHKAIVERNGIKYYFIINFNHENQKPLELRTEDAKDCEEWVTAISRASYKTLVTEHEALMQKYLHLLQIVETEKKVAKQLRQQIEDGEVEVERLKSEIASLLKDNERIQSTQTAAPNEDVDIKKIKKVQSFLRGWLCRRKWKSIIQDYSRSPHADSMRKRNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPSITHDDVSSIFLNSETIMFLHQIFYQGLKARISSWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDFDKLLKQYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLEYAKSKLEELSRIMHDEVSETENIRKNLAIERMIVEGCEVLLDTSQTFVRQGCLIQVPMSEKSRITRGRLGSLSLRKEGERQCFLFSKHLLICTRSSGGKLHLTKNGVVSLMDCTLLEENDDDDSEYHPKQQDGDHLDFKISVEPKDSAPFVVILLASSRQEKAAWTSDISQCVDNIRCNGLMMNAFEENSKVSVPQMIKSDSSLYCDDVDIRFSKTMNSCKVLQIRYASVERLLERLTDLRFLSIDFLNTFLHSYRVFTTADIVLEKLIAIYRKPVSAIPARSLELLFASNQNNKLLYGEPPKSPRATRKFSSPPPLSITKSSSPSRRRKLSLNIPIITGGKALDLAALGCSTNGYQSTCPAPPPYSKTTLDINKLYVSGSFPSKVGEGEEPPAERDEEPGTQRQNSEVSTRGDSDNEQTDGDEAETDTSPTRSPTTPVSQRGRNSADFTLFSYNNGIVMTACREHDNSRSNLSAASAFAIATAGANEGTPTKETYRRMSLATAGFPSDQRNGDKEFVIRRAATNRVLNVLRHWVSKHAQDFETNLQLKTKVICFLEEVIHNPELLAQERKAAANIIRTLTQEDPGDSQVTLEEIENMVLDGPMELFESLSALEIAEQLTLLDHLIFKKIPYEEFFGQGWMKNDKNERTPYIMNTSKHFNLMSNLIATEILRGEEPAQRGCTIEKWVAVADICRCLHNYNAVLEITSSLNRSAIYRLKRTWIKVSKQTKTLIDRLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTSYKIEHQPKVTQYLLDSSTVLDEEGLYEASLRLEPKLPT	NCBI Protein >AAH83032|LOC494866 protein [Xenopus laevis] STHASAGSFPSKVGEGEEPPAERDEEPGTQRQNSETSTRGDSDNEQTDGDEAETDTSPTRSPTTPVSQRGRNSADFTLFSYNNGIVMTACREHDNSRSNLSAASAFAIATAGANEGTPKKETYRRMSLATAGFPSDQRNGDKEFVIRRAATNRVLNVLRHWVSKHAQDFETNLQLKTKAICFLEEVIHNPELLAQERKAAANIIRTLTQEDPGDSQVTLEEIENMVLDGPVDPFESLSALEIAEQLTLLDHLIFKNIPYEEFFGQGWMKNDKNERTPYIMNTSKHFNLMSNLIATEILRGDEPAQRGCTIEKWVAVADICRCLHNYNAVLEITSSLNRSAIYRLKRTWIKVSKQTKTLIDRLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTSYKIENQPKVTQYLLDTSTVLDEEGLYEASLRLEPKLPT

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene			Xl.49691 [+] Xl.65983
Unigene EST Profile			EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	RASGRF1
mouse		MGI	Rasgrf1	All(11) Targeted, knock Out(8) Targeted, other(1) Chemically Induced(2)
zebrafish			rasgrf1

Publications
First:		Identification of a protein kinase multigene family of Dictyostelium discoideum: molecular cloning and expression of a cDNA encoding a developmentally regulated protein kinase. [Proc Natl Acad Sci U S A 1991]
Most recent:		Multisite phosphoregulation of Cdc25 activity refines the mitotic entrance and exit switches. [Proc Natl Acad Sci U S A 2012]
		View All Papers 2 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		guanyl-nucleotide exchange factor activity
Biological:		intracellular signaling cascade small GTPase mediated signal transduction
Cellular Component:
EC:
KOG:		[T] Ras1 guanine nucleotide exchange factor

Reagents		tropicalis	laevis
Clones			open biosystems
			geneservice/RZPD imagenes
Affymetrix 1.0		StrJgi.812.1.S1_at [+] StrEns.1419.1.S1_s_at
Affymetrix 2.0			Xl2.49691.1.S1_at

Symbol legend[+]

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   - Literature Or Expression Images