Gene Symbol: clcn2 Gene Name: chloride channel, voltage-sensitive 2 Synonyms: clc2, eca2, eca3, egi3, egma, ejm6, ejm8, clc-2, egi11 Add Xenopus synonyms Gene Function: voltage-gated chloride channel component Interactants: clcn1(6) , cftr(3) , clcnkb(3) , nppb(3) , bsnd(2) , cic(2) , mlc1(2) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene
mRNA		NCBI Nucleotide >XM_002935146|PREDICTED: Xenopus (Silurana) tropicalis chloride channel protein 2-like (LOC100488889), mRNA ATGTATGGCAGGTATACACAGGACCTTGGAGTTTTTGCCAAAGAGGAGGCAGCACGTATTCGACAAGAGAGAGAAGTCCACAGACCTGCCACAAAACCGCAAACTGTAGAACTGCGAGAGTATGATGAGAGTCGCTGTGCCAAGTGCAAAACTCACAAGTGGATGTATGGTGGCTTGGACAATAATGTTTTTCTGCAGTATCTAGCATGGGTCACATATCCTGTAGTCTTAATTACTTTCTCTGCTGGATTCACACAGATCCTCGCCCCCCAAGCAGTTGGTTCAGGTATACCAGAGATGAAGACTATTCTGCGTGGCGTTGTGCTAAAGGAGTATCTCACACTGAAAACCTTCATTGCAAAAGTTATTGGGTTAACATGTGCACTTGGGAGTGGTTTGCCGCTGGGCAAAGAAGGCCCATTTGTTCATGTTGCAAGTATGTGTGCTGCTCTGCTAAGTAAATTGATGTCTCTTTTTGGAGGAATTTATGAGAATGAGTCGCGTAATATTGAGATGCTTGCTGCAGCCTGTGCTGTGGGTGTTGGGTGCTGCTTCGCTGCTCCTATTGGAGGAGTGCTGTTTAGTATTGAAGTCACCTCCACATTCTTTGCTGTCAGAAATTACTGGCGTGGGTTCTTTGCTGCCACCTTCAGTGCATTTATTTTTCGTGTTCTTGCAGTGTGGATCAAAGATGAAGAAACCATCACAGCATTATTCAAAACCAGTTTTCGTCTCGACTTTCCATTTGATCTTCAGGAGCTCCCAGCATTTGCTGTGATCGGGATTGCCAGTGGTTTTGGGGGTGCTCTTTTTGTATATCTTAATCGGAAAATTGTAGAGTTTATGCGAAAACAGAAAACAATTAACAGATTTCTGATGAAAAAACGCTTGCTGTTTCCTGCATTGGTTACACTGCTTGTGGCCACTCTGACATTCCCACCAGGCTTTGGCCAGTTCATGGCTGGGCAGCTAACACAGAAGGAGACACTTGTGACCTTATTTGATAACTACACATGGGCACAGCAAGGCATCTCAGAGGACTTTGCTTACAGGGGAATCTCAAGTGTCTGGAAACATCCAAAAGCTAATGTCTTTGTCACATTGGTTGTCTTCATACTAATGAAGTTTTGGATGTCAGCTTTGGCCACCACCATCCCAGTGCCATGTGGAGCATTCATGCCAGTCTTTGTTATTGGTGCTGCCTTTGGAAGGTTAGTGGGTGAGAGCATGGCTGCATGGTTCCCCGATGGCATTCATACAGATGGGAGTACTTACAGAATAGTGCCAGGGGGATATGCAGTAGTGGGTGCAGCTGCCCTTTCTGGAGCTGTCACACACACCGTCTCCACAGCAGTCATTGTGTTCGAACTCACCGGCCAAATCTCTCACATTCTGCCAGTGATGATTGCAGTCATATTGGCTAATGCAGTGGCTCAGAGTCTTCAGCCATCACTTTATGACAGTATTATCCGTATTAAAAAGTTGCCATACCTTCCAGAGCTGGGATGGGGACATCAGGAGAAGTATAATGTAAGGGTGGAGGACATCATGCTGAGGAATATCCCTTTTGTGACTCTGAACTCTAAATATCGTGACCTTCAGGAGCTGCTTACAAACTGCCACTTGAAATGCCTAGCACTGGTGGAGACAGCAGAGTCTATGATCCTGCTGGGCTCCATTGACCGCTCACAGTTACTGTCACTCCTGCGGTTTCAGCTCAGCTCAAAAAGGCGCCTGCAGCAACTTCGTGAGCGAGAATCTAGTGGAAAGAAACAAACTGAGAACAGCGTGCGATTTCAGATAACAACAGAAGAATCCACATTCTCACCACCACAAGGAGAGACTAGGAAGCCTTTAAAACCAGCCCTGAAACATACACTCAGTAGCCTGACTGAGTCTCCAGCAGATGATTCTGATAACTCAGTAACTGCATTGAAAAGTATCTTCTGTGCCAAAGACTTCAGTGAACCCCTGGAGGTTGTCAAGGATCCTGCGTCTCCTTCAAAAAAAAACAAATCCAGGTTGAAGCATCGGCATAGGCTGGGTGAAGATCTGGATGAGATAGATACTATGACTCAGTCACAGATCTTGGAATGGGAAGAGATCCAACTTGAAGAACCAATCAACTTAAACAACTGCAAAATAGATCCTGCACCATTCCAGCTCGTGGAAAGGACATCACTGCATAAAGCACACACAGTTTTTTCCCTGCTTGGAATGGACCATGCGTATGTAACCAGTATAGGGCGGCTTATTGGAATGGTGACACTAAGAGAGCTCCGGAAAGCCATAGAGGGCTCAGTAACAGTGAAAGGTGCAAAATTACGTCCACCTTTGGCCAGCTTTAGGGATAGTGTTACAAGTAGCAGTGACACAGAGACCACCAACGTCAACAAACTATGGGAGAGAAGTCGCCGACACCTACTTCCCCGTGAATCCAGCCCATCCGACAGCGATGATAAATGACAAGGGAGCTACTTATCTGGAGTGCACATACACTTCTTCCATTTTCTTCCAGAGGGAAGCACTTTTCAATGCTCTCTTTATCACTGTGGGGCTATTCTTGGCTGAACATTTTAGTCAGTGTCTTCCAGCACCATTCCAGCTAAAAAACCTGGTGGTTTGGGCATTTGAACATACTATATTGATGTTTAGTTTGCAACTCAATGTAATGATCTGACAGTTTGCAATGTTCAGAGCACCTGATCAATGAAACTGGGGCACATGTCCAGGAGCAGTACAGTAGCACAGTCATCTCTTTCACTCCATTTCCTGCACAGAGAGTGAAGGGTAACACTGCCATTCATTTTATATTGTTTAATTAAAATATTATGTCAAGAATTGAGCCTGCAAACCCCCCACTGACATGGGAAACCATTGTTCAGTAAAGTACACAAAGACAAAAGCTTGGGAGAATCAGTTATTTCCCAGCTCACATGGTTGGTATTGAGGACTCTTCACCTATACTGGCATTATGAACCAATGAGCACAATGTAGAAACAATGGCAGTTACTCTACTTATTACCTCCCAAGAGTAATGGGACCTAAGGCATTCAGCAATTCCCAGAACTGTATTTACTATTTATTACCTTGCATTCACATGAGAACAAAATTCACTTGACATCTCTTACTGATGTACAGAGGGACCTATTACCTCCCACGGATATGGAGGAACTGCCTACCTCTGGGGAACTGAATTATTGCACCTTCTAAGAATTGCCAATTACAGGGGTGTGCCAGTAGCAAGAGAACACAATAGAGCTGCCATTGCAAAGTGGCACTGTTCCACCGAGCATTTCTTTATAAGTGTTACAGAGGAGGAAAAGACCTGTCACATGCAGGTGTGGCATTCTTAATAAAAACATACCTTACTTATCACTGATATGATGCAATGCATTTGACTATTTTTGTAACATTTCTGTATATCATTTTTAACAATAAAACTGGAATAAATGCAGTTATATCAAGA
Protein		NCBI Protein >XP_002935192|PREDICTED: chloride channel protein 2-like [Xenopus (Silurana) tropicalis] MYGRYTQDLGVFAKEEAARIRQEREVHRPATKPQTVELREYDESRCAKCKTHKWMYGGLDNNVFLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCALGSGLPLGKEGPFVHVASMCAALLSKLMSLFGGIYENESRNIEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVWIKDEETITALFKTSFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVEFMRKQKTINRFLMKKRLLFPALVTLLVATLTFPPGFGQFMAGQLTQKETLVTLFDNYTWAQQGISEDFAYRGISSVWKHPKANVFVTLVVFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLVGESMAAWFPDGIHTDGSTYRIVPGGYAVVGAAALSGAVTHTVSTAVIVFELTGQISHILPVMIAVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGHQEKYNVRVEDIMLRNIPFVTLNSKYRDLQELLTNCHLKCLALVETAESMILLGSIDRSQLLSLLRFQLSSKRRLQQLRERESSGKKQTENSVRFQITTEESTFSPPQGETRKPLKPALKHTLSSLTESPADDSDNSVTALKSIFCAKDFSEPLEVVKDPASPSKKNKSRLKHRHRLGEDLDEIDTMTQSQILEWEEIQLEEPINLNNCKIDPAPFQLVERTSLHKAHTVFSLLGMDHAYVTSIGRLIGMVTLRELRKAIEGSVTVKGAKLRPPLASFRDSVTSSSDTETTNVNKLWERSRRHLLPRESSPSDSDDK

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC
Synteny		Metazome

Expression		tropicalis	laevis
UniGene			Xl.58793
Unigene EST Profile			EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	CLCN2	OMIM:607628 OMIM:607682 OMIM:607631 OMIM:606904
mouse		MGI	Clcn2	All(6) Targeted, knock Out(3) Chemically Induced(1) Targeted, other(2)
zebrafish

Publications
First:		A chloride channel widely expressed in epithelial and non-epithelial cells. [Nature 1992]
Most recent:		Characterization of an outward rectifying chloride current of Xenopus tropicalis oocytes. [Biochim Biophys Acta 2013]
		View All Papers

Functional Ontologies
GO: Molecular:		voltage-gated chloride channel activity
Biological:		chloride transport
Cellular Component:		membrane
EC:
KOG:		[P] Cl- channel CLC-2 and related proteins (CLC superfamily)

Reagents		tropicalis	laevis
Clones			open biosystems
			geneservice/RZPD imagenes
Affymetrix 1.0
Affymetrix 2.0

Symbol legend[+]

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