ttn Summary [species: Xenopus laevis and Xenopus tropicalis]

Summary

Expression

XB-GENEPAGE-6031745

[provisional- machine annotated only]

Gene Symbol: ttn [Predicted: Source is Human Entrez Gene]

Gene Name: titin [Predicted: Source is Human Entrez Gene]

Synonyms: titin, tmd, cmh9, cmd1g, cmpd4, eomfc, hmerf, lgmd2j Add Xenopus synonyms

Gene Function: Projectin/twitchin and related proteins

Interactants: agtr1(4) , agtr2(4) , atm(4) , slc4a1(4) , slc4a2(4) , ecd(3) , actn1(2) View All

XB-GENE-6031746

XB-GENE-6485685

Molecules	tropicalis	laevis
Gene	JGI XT Genome 7.1 JGI XT Genome 4.1
	Entrez Gene
mRNA	NCBI Nucleotide >CR855822\|Xenopus tropicalis finished cDNA, clone TTpA004n04 TAACTGCAGATGCCATAACACTTATCTGGGCGCCACCAAAAGATGATGGTGGCTCTGAAATCACTAATTACATCCTGGAAAAGAGGGACTCTGTAACCAATAAATGGGTAACCTGCGCTTCAGCTGTTCAAAAGACCTCATTTAGAGTTACAAGACTCCATGAAGGTACCGAGTATATCTTTAAAGTTAGTGCTGAAAATAAGTATGGAGTTGGAGAAGGCCTTAAATCAGAGTCGGTTATTGCAAGGCATCCATTTGATGTACCTGATGCTCCTCCACCTCCAAAGATAATGGCCATGAAGCATGATTCTGCAACTTTAACTTGGGTGGATCCAAGAAAGACTGGTGGCTCACCAATAACAGGTTACCATATTGAGTACAAAGAAAGAAACAGCCTGCTTTGGAAGAGGTTAAGTACAACTCCTTTGAGAATGAAGGATTGCAGAGTTCCAGGATTAACTGAAGGACTTGAGTATGAATTCAGAGTTATGGCTATCAACCTTGCAGGAATTGGTAAACCAAGTCTACCAACAGAACCAGCCGTGGCCCTTGATCCAATTGATCCTCCTGGAAAACCTGAGGTCATTAGTGTGACAAGGAGCTCAGCAACTCTGATTTGGACAGAACCAAAATATGATGGTGGTCATAAACTTGTTGGATATATTGTTGAGAAACGTGATTTGCCTGCAAAGTCTTGGATGAAGGCTAACCACATTAATGTCCAGGAGTGTGCTTTTACTGTAAATGATCTAATTGAAGGTGGAAAATATGAATTCAGAATAAAGGCTAAAAATACTGCAGGAGCAATAAGTCCTCCATCAGAGACAACAGGAACAGTTGTATGCAAAGATGAGTATGAGGCACCCACTATTACTCTTGATCAAGCTATAAAAGAAGGCTTAACTGTTAAGGCAGGAGATACCATTGTCATGACTGCTACAAGCATCCTTGGCAAGCCACCTCCAACATCTGTTTGGTCCAAAGCAGGAAAGGACTTTAAACCATCTGATATTGTACAGATTGAAACAGGTCCAACATCTTCCACTCTATCTGTTAAATATGCATCCCGTAAAGACTCTGGGGAATACACAATTACTGCCAGCAATCCTTTTGGCACCAAAGAGGAACATGTACATGTAAAAGTTTTAGATGTGCCTGGACCCCCTGGGCCTATTGAAGTGAGCAATGTATCTTCTGAAAAAGCTACACTTAACTGGACACCTCCAGCCGAAGATGGTGGCTCACCCATTACATCATACACTTTGGAAAAGAGAGAGACCAGCCGTTTGCTCTGGACCTTGGTAGCTGAAAATATACAGTCCTGCAGACATGTTGTGAGCAAGCTGATCCAAGGAAATGAATACATCTTCCGTGTCTCTGCTGTAAACCATTTTGGTGTGGGTGAACCTGTACAATCTGAACCAGTCAAGATGGTCGATAGCTATGGCCCCCCAGGTCCTCCTGGTAAACCAGAAGCAACCAATGTAACAAGCACAACAGTAACCATTGCCTGGAAACGACCAACTGATGATGGTGGCAGTGAAATCACTGGTTACTATGTTGAAAAAAAAAAAAAAAAAA
Protein	NCBI Protein >CAJ83195\|titin [Xenopus tropicalis] TADAITLIWAPPKDDGGSEITNYILEKRDSVTNKWVTCASAVQKTSFRVTRLHEGTEYIFKVSAENKYGVGEGLKSESVIARHPFDVPDAPPPPKIMAMKHDSATLTWVDPRKTGGSPITGYHIEYKERNSLLWKRLSTTPLRMKDCRVPGLTEGLEYEFRVMAINLAGIGKPSLPTEPAVALDPIDPPGKPEVISVTRSSATLIWTEPKYDGGHKLVGYIVEKRDLPAKSWMKANHINVQECAFTVNDLIEGGKYEFRIKAKNTAGAISPPSETTGTVVCKDEYEAPTITLDQAIKEGLTVKAGDTIVMTATSILGKPPPTSVWSKAGKDFKPSDIVQIETGPTSSTLSVKYASRKDSGEYTITASNPFGTKEEHVHVKVLDVPGPPGPIEVSNVSSEKATLNWTPPAEDGGSPITSYTLEKRETSRLLWTLVAENIQSCRHVVSKLIQGNEYIFRVSAVNHFGVGEPVQSEPVKMVDSYGPPGPPGKPEATNVTSTTVTIAWKRPTDDGGSEITGYYV

Genomic	tropicalis
Genome Browser	Xenbase	Xenbase JGI UCSC

Synteny	Metazome

Expression	tropicalis	laevis
UniGene	Str.52078 [+] Str.57615
Unigene EST Profile	EST Profile
GEO data		GEO
Images	3 expression image(s) for tropicalis and laevis

Orthology	MOD	Entrez Gene	Genetic Phenotypes	Morphants
human	OMIM:Gene, HGNC	TTN	OMIM:604145 OMIM:608807 OMIM:611705 OMIM:603689 OMIM:600334
mouse	MGI	Ttn	All(11) Targeted, knock Out(2) Targeted, other(7) Chemically Induced(1) Spontaneous(1)
zebrafish	ZFIN ZFIN	ttna ttnb	14 Lines(s) 1 Lines(s)

Publications
First:		In vivo phosphorylation of titin and nebulin in frog skeletal muscle. [Biochem Biophys Res Commun 1987]
Most recent:		Analysis and elimination of a bias in targeted molecular dynamics simulations of conformational transitions: application to calmodulin. [J Phys Chem B 2012]
		View All Papers 1 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		myosin light chain kinase activity
Biological:
Cellular Component:
EC:		now EC:2.7.11.18
KOG:		[Z] Projectin/twitchin and related proteins

Reagents	tropicalis	laevis
Clones	open biosystems
	geneservice/RZPD imagenes
Affymetrix 1.0	Str.52078.1.S1_at [+] Str.52036.1.S1_at Str.44126.1.A1_at	Xl.15870.1.A1_at [+] Xl.26097.1.S1_at
Affymetrix 2.0		Xl2.15870.1.S1_at [+] Xl2.26097.1.S1_at

Symbol legend[+]