The crebbp protein functions as a transcriptional coactivator and possesses intrinsic histone acetyltransferase activity, modifying histones to regulate chromatin structure and gene expression. It loca...[+]

The crebbp protein functions as a transcriptional coactivator and possesses intrinsic histone acetyltransferase activity, modifying histones to regulate chromatin structure and gene expression. It localizes to the nucleus and is involved in embryonic development, particularly in patterning the neural crest, craniofacial formation, and development of the head, face, and pharyngeal arches. It interacts with other transcription factors like sox9 and tfap2a during these processes. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD