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Summary Expression Gene Literature (14) GO Terms (10) Nucleotides (312) Proteins (50) Interactants (287) Wiki
XB-GENEPAGE-493882
Gene Symbol:
wdr5

Gene Name:
WD repeat domain 5

Synonyms:
xwdr5 , swd3 , big-3 , wdr5-a , wdr5-b ( Add synonyms , Nomenclature history )

Gene Function:
WD40 repeat-containing protein

Protein Function :
Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation a...[+]


InterPro :
WD40 repeat CS , WD40 repeat dom sf , Swd3/WDR5 , WD40 repeat [+]

Interactants:
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Diseases: 


External Links:
 
Xenbase Gene ID XB-GENE-493883 XB-GENE-6255108 XB-GENE-866297
Gene Symbol wdr5 wdr5.L wdr5.S
Chromosome Chr8 chr8L chr8S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 496891
446809
447447
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein RefSeq Swiss-Prot  More.. NCBI Protein RefSeq  More.. NCBI Protein RefSeq  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine wdr5 wdr5.L wdr5.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC, AGR, Monarch, OMIM, GeneCards WDR5 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Wdr5 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Wdr5 Ensembl
zebrafish
ZFIN, AGR wdr5 ZFIN Ensembl
chicken
GEISHA WDR5B Ensembl
fruit fly
Publications
First WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development., Cell 2005    
Most Recent Xenopus to the rescue: A model to validate and characterize candidate ciliopathy genes., Genesis 2021    
All View All Papers 2 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 3 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 10 terms 0 term 0 term
PANTHER wdr5
KEGG Pathways K14963 K14963 K14963
KOG [R] WD40 repeat-containing protein
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks wdr5
Antibodies wdr5 Ab1
Morpholinos wdr5 MO4 wdr5 MO1 , wdr5 MO2 , wdr5 MO4 wdr5 MO1 , wdr5 MO2 , wdr5 MO4
ORFs wdr5 ORF1 wdr5.S ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

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