Gene Symbol: bcl2 Gene Name: B-cell CLL/lymphoma 2 Synonyms: bcl-2, xBcl-2, xbcl2 Add Xenopus synonyms Gene Function: regulator of cell death/apoptosis Interactants: bax(16) , bcl2l1(12) , bid(7) , casp3(7) , tp53(6) , casp9(5) , myc(5) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		NCBI Nucleotide >XM_002934396|PREDICTED: Xenopus (Silurana) tropicalis apoptosis regulator Bcl-2-like (LOC100485267), mRNA GGACAAGCAGTGTCCCGCCTCCAGCCAGCCACGCTGTGTGCTACACGGAGGCAAGATGAAGAAGGCAACAAGGACAATAAAAAGAAACTAAATCACACACAAACACCACCTCTGCTATATTCTCCTGTGTTTAAGAATCTACAAGAATGTCTTTTACTGGCCAGAGTTTATTCCTGTGCTGGATTAAATGAGAGGGATTAGTACTTTTTTTTGCCGTTTCTGAGCAGCAGCATATGTGTGTGGGGTGTGAGAGGCTGAATAAATGGGAGTGAGCAGAACACTGTAGCAGGATCTCCAGTCAGAGGAGGTGGAAAAAAAACTGCATTTTGCTTTCACTGGCGCTTCTGGGTTGCCTGGGTGGCCTCTAAAGCATTTCCTACACAAGGATGCTTATGCGATGTTTGGACTGTTTCATTGATGCATTTAATTCCCCCTGAGGATTTAAGTCAATATAACCCCAGCATATCTGGAACTTGTTTCATGGATTCAGATGAACAGGGAAACCCAACAGCAGAGCAAGATCAAGTAGGGAATGTCCCTTGAAAAAGCGCAGCTAACAATGAAAGCACCTTTAGGAGGGAAATTTCAATAAAGCTACAGAGCTCCACAAGGAGGAAGAGGGGGAGGAATATTTACAGCAAAAGAATGAAAGAGCTGCCGCAGGACCTTTCGCTTACAGCAAATACATTATAAGAGCTAAAGGAGCTGTTTGAGTAGTTCTGGGCGAAGTATTTTGGTTTATAACCGAATATAATCTTTTCACCAATCCCCTGCCATTAGTCCGTGGACAAATATGGCTCATCCTAGGAGAGGAGGCTATGATCACCGGGACATAGTGGTAAAATATATCCATTATAAACTGTCTCAAAAGGGGTATGAATGGGAAGAGGGGCGGCAGCAGGTCTCTGCTGAGCACCCTCAAGCTTCTGCTGCTATTAGTAATTATTCTGATGATGGAGAAATGCCTGCTGCTTCCGCAGATTCACGTGGACCACCTCAATCTTCACTCGCATCTGCTGCTGCTTCCTCAGATGAGGAAACCCCAAGTAATGCTCCAGCCACCTTCGTGGGCAATACACCTGCTGTTCCCAGGGGGTCTGCACCTGCTGCTTCACCCTTAGCTGAATTGAACGTTGTACCAAGAAATCTTAATGTTAACCCAGATGCCAGTCGAGAAGCAGATGGTGATGATGATGATGATGAAGCAGCTATGCAGCCGGTCCCTCCAGCAGTGCTACAGACCTTAAGTCGAGCTGGAGATGAGTTCTCTCGCCTCTATCAGCAAGATTTTAGACAGATCTCAGGGCTCCTCCATTTAACCCCATCCACAGTTAGGGTGCGCTTTGCAACAGTAGTGGAGGAGCTCTTTCATGATGGGGTCAACTGGGGAAGGATTGTTGCTTTTTTCGAGTTTGGTGGGGTCATGTGCGTGGAAAGTGTTAATCGAGAAATGTCTCCTCTGGTGGATTCCATTGTGGGTTGGATGACAGAGTACCTAAACAGTCACTTGCAAAATTGGATCCAGGAACAGGGAGGATGGGATGCTTTTGTGGAGCTGTACAACAGCAATATCCGGCCACCATTTGACCCCAGCTGGTTATCCATCAAGACAATATTAAGCCTTGCTGTGGTTGGAGCCTGCATCACAATAGGGGCATATCTTGGTCACAAGTGAAGATCGCACATGATTTGGAACAGTAATATCCAGACTTAGAAGAATTGGACACTTTGATGTGTAAAACTAGTGGACCAATTGTTAAATCAGCTATAACTGCCAAAGGAGGTTTCACTTTATTTTCTGTAGAAATATTTTCTTTTTATAGAGGTTTTATTTATTAAAGTTCTTTGCATTTCAA	Refseq >NM_001146093|Xenopus laevis B-cell CLL/lymphoma 2 (bcl2), nuclear gene encoding mitochondrial protein, mRNA ATGGCTCATCCTAGAAGAGGAGGCTATGATCACCGGGACATAGTGGTAAAATATATCCATTATAAACTATCTCAGAAGGGGTATGCATGGGAAGAGGGAAGGCAGCAGGTCTCTGCTGAGCACCCTCAAGCTTCTGCTGCTATTAGTAATTATTCTGATGATGGAGAAATGCCTGCTGCTTCCGCAGATTCACGTGGACCACCTCAGTCTTCACTCGCATCTGCTGCTTCCTCAGATGAGGAAACCCCAAGTAATACTCCAATAACCTTTGTGGGCAATGCACCTGCTGTTCCCAGGAGGTCTGCATCTGCTGTTTCACCCTTAGCTGAATTGAATGTCGAACCAAGAGATCTTAATGTTAATCCAGATGCCAGTCGTGCTGCAGATGGTGATAATAATGATGCTGATGGTGGTGATGAAGCTGTTATGCAGCCAGTCCCTTCGGCAGTGCTACAGACCTTGAGTCGAGCTGGAGATGAGTTCTCTCGCCTATATCAGCAAGATTTCAGACAGATCTCAGGGCTCCTCCATTTAACCCCATCCACAGTTAGGGTGCGCTTTGCAACAGTGGTGGAGGAGCTCTTTCATGATGGGGTAAACTGGGGAAGGATTGTTGCTTTTTTCGAGTTTGGTGGGGTCATGTGCGTGGAGATTGTTAACCGCGAAATGTCTCCTCTGGTGGACTCCATTGTGGGTTGGATGACAGAGTACCTAAACCGTCACTTACAAAATTGGATCCAGGAACAGGATGCATTTGTGGAGCTGTACAACAGCAATATCCAGCCACCGTTTGACCAGAGCTGGTTATCCATCAAGACAATATTAAGCCTTGCTGTGGTTGGAGCCTGCATCACAATAGGGGGCATATCCTTGGCCACCAAATAA
Protein		NCBI Protein >XP_002934442|PREDICTED: apoptosis regulator Bcl-2-like [Xenopus (Silurana) tropicalis] MAHPRRGGYDHRDIVVKYIHYKLSQKGYEWEEGRQQVSAEHPQASAAISNYSDDGEMPAASADSRGPPQSSLASAAASSDEETPSNAPATFVGNTPAVPRGSAPAASPLAELNVVPRNLNVNPDASREADGDDDDDEAAMQPVPPAVLQTLSRAGDEFSRLYQQDFRQISGLLHLTPSTVRVRFATVVEELFHDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDSIVGWMTEYLNSHLQNWIQEQGGWDAFVELYNSNIRPPFDPSWLSIKTILSLAVVGACITIGAYLGHK	Refseq >NP_001139565|B-cell CLL/lymphoma 2 [Xenopus laevis] MAHPRRGGYDHRDIVVKYIHYKLSQKGYAWEEGRQQVSAEHPQASAAISNYSDDGEMPAASADSRGPPQSSLASAASSDEETPSNTPITFVGNAPAVPRRSASAVSPLAELNVEPRDLNVNPDASRAADGDNNDADGGDEAVMQPVPSAVLQTLSRAGDEFSRLYQQDFRQISGLLHLTPSTVRVRFATVVEELFHDGVNWGRIVAFFEFGGVMCVEIVNREMSPLVDSIVGWMTEYLNRHLQNWIQEQDAFVELYNSNIQPPFDQSWLSIKTILSLAVVGACITIGGISLATK

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.38678	Xl.85303
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	BCL2
mouse		MGI	Bcl2	All(9) Targeted, knock Out(3) Targeted, other(3) Chemically Induced(1)
zebrafish		ZFIN	bcl2

Publications
First:		Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells. [Mol Cell Biol 1993]
Most recent:		Eukaryotic initiation factor 6 (eif6) overexpression affects eye development in Xenopus laevis. [Differentiation 2012]
		View All Papers 7 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:
Biological:		regulation of apoptosis
Cellular Component:
EC:
KOG:		[T] Anti-apoptotic Bcl-2 family proteins, prevent opening of mitochondrial porin channel

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.38678.1.S1_at
Affymetrix 2.0

Symbol legend[+]

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