The slc8a3 gene encodes a sodium-calcium exchanger protein, which is a plasma membrane transport protein. This exchanger mediates the electrogenic exchange of sodium and calcium ions across the plasma ...[+]

The slc8a3 gene encodes a sodium-calcium exchanger protein, which is a plasma membrane transport protein. This exchanger mediates the electrogenic exchange of sodium and calcium ions across the plasma membrane, utilizing the sodium gradient to extrude calcium from cells. It functions in maintaining intracellular calcium homeostasis. Expression is detected in the oocyte, brain, spinal cord, eye, and ear. In neurons, it contributes to the regulation of cytosolic calcium levels following action potentials. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD