[provisional- machine annotated only] Gene Symbol: cdc45 [Predicted: Source is Human Entrez Gene] Gene Name: cell division cycle 45 [Predicted: Source is Human Entrez Gene] Synonyms: cdc45l, cdc45l2, porc-pi-1 Add Xenopus synonyms Gene Function: CDC45 (cell division cycle 45)-like protein Interactants: mcm2(13) , cdc7(11) , cdk2(11) , rpa1(10) , pola1(9) , antxr1(8) , atr(8) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		NCBI Nucleotide >BC121628|Xenopus tropicalis CDC45-like, mRNA (cDNA clone IMAGE:7859960), partial cds CTTGTTGCACCTGATGTTGATGCTCTCTGCGCCTGTAAGGTACTTCAGGCATTATTTCAGTGTGATCATGTGCAGTATACCTTGGTCCCAGTCTCTGGCTGGCAGGAACTTGAAACATTGTTTCTTGAACATAAAGAACAGTTCCGTTACTTTGTTCTCATAAACTGTGGTGCAAACATAGACCTTCTAGAGACTCTACAGCCCCAAGAAGAGGCTATCTTTTACATCTGTGACACTCACAGACCAATAGATGTGGTTAATATATACAATGATAGTCAGATCAAGCTGCTGATCCGGCAGGATGATGACTTGGAAATACCTGCTTATGATGACATTTTCAATGATGATGAAGATGAGGAGGATGGGGATGATTCTGGAAATGAAAGTGATGGAGCAGAACCTTCTGGAAAGAGGAGGCGATTTGATGAGGCAGCAGTGGAACGAAGGATAGAGAGGAGACGCCAGAGGAGGGAGTGGGAGGCTCGAAGGAGAGAGATTCTTTTTGACTATGAGCAGTATGAATATCATGGAACATCATCTGCAATGATGATGTTTGAGTTGGCTTGGATTATGTCTAAGGATTCAAATGATATGTTATGGTGGGCAATTGTTGGGCTGACAGACCAGTGGGTTCAGGACCGAATAACTCAAATGAAATATGTGACCGATGTTGGAACCCTCCAGCGCCATGTTTCCCGACACAACCACCGCAATGAGGATGAAGAAAATTCACTCTCAATTGACTGCATGAGGATAGCATTTGAATATGATCTGCGTCTTTCGCTGTATCAGCATTGGTCTCTGTATGAAAGCATCTGTAACTCCTGTTACACATCTGCTAGTCTCAAGCTATGGTCTGTGCAAGGGCAGAAAAAACTTCAAGAATTTCTTGCAGACATGGGGATGCCTCTTAAGCAAGTAAAACAGAAGTTTAATTCTATGGACATATCTTTAAAGGAAAATCTACGGGAAATGCTTGAGGAGTCAGCAAATAAATTTGGAATGAAGGATGTGAGGGTGCAGACGTTCAGTGTGCAGTTTGGATTTAAGAACAAGTTTCTGGCCAGTGACATTGTATTTGCTGTGCTTTCTCTCCTGGAAAACATTGAACGAGATGAGAAGGGAACCGATAACTTTATCAAGGCCTTAGATAGCCTCTCCAGGAGTAATCTGGACAAACTGCACACTGGCCTGGAAATGGCCAAAAAACTTTTACGTGCTATTCAACAGACAGTGGCCAGCTGCATCTGCACAAACCTTATATTGTCCCAGGGCCCCTTTCTCTACTGTTACCTGATGGAGGGGACACCAGATGTTAAGATGTTTGCCAATCCTATATCTCTCTGCCTGCTTTGTAAATACTTGCTGAAGTCCTTTGTGTGTTCTACCAAAAACAAACGCTGTAAGTTGCTTCCACTGGTGTTGGCAGCTCCTCTGGATGCGGAGAAGGGGACGGTGATCATGGTGGGGATTCCCCCTGAAGCAGAGAGCTCAGACAAGAAGAATTTTTTTGGACGAGCATTTGAGAAAGCAGCGGAGAGCACCAGTTCTCGGACACTCCACAACCATTTTGACATGTCCATAATTGAGTTAAGGACAGAGGACCGCAGCAAGTTCCTGGATGCGCTTATCTCTCTGTTGTCATGAGTAACCCATGGCTATTTTCACCTGCCTCTTCTCAAGATCTCTTACTGACTTTTGTAAATGTGCATTTTAGTCTCCCATTTTAAAGTGTCTTTTAAAAAAATATATATGTACTGACTAAATTATTTAGCTGAATGTATTAAGCCCAGTGTAATAACATGTTTGTCTGTATCTAAAACTGTAAATAAAAATTAAATTTCTATTGTAAAAAAAAA	Refseq >NM_001088373|Xenopus laevis cell division cycle 45 homolog (S. cerevisiae) (cdc45), mRNA GTGATGTCACTGAGAAACGGTTTGTTTGATTGGTCAGCGCTGCTCTAAGGGATTTTGGCGCCACTTTCGAGGGCAGCAGCCGTCATCAGCCGGTCGAGATGTTTGTGAGTGATCTCCGTAAAGAGTTTTTCGACGTGATCGTTACCGAGCGCGTTCTTCTCCTGGTTGCTCCTGATGTTGACGCACTATGCGCCTGTAAGATCCTTCAGGCATTATTTCAGTGTGATCATGTACAGTACACTTTGGTACCAGTCTCTGGTTGGCAGGAACTTGAAACATTGTTCCTTGAACATAAGGAACAGTTCCGTTACTTTGTGCTCATAAACTGCGGTGCAAACATAGACCTGCTAGAGACTCTACAGCCCCAAGAAGAGGCTATCTTTTACATCTGTGACACTCACAGGCCAATAGATGTGGTCAATATATACAACGATAGTCAGGTCAAGTTGCTGATCCGACAAGATGACGACTTGGAAATACCTGCTTATGATGATATTTTCAATGATGATGAAGAGGATGGGGAGGATTCTGGAAATGAAAGTGATGGAGCAGAACCCTCTGGAAAGAGAAGGCGATTTGATGAGGCAGCAGTGGAAAGAAGGATTGAGAGGAGACGGCAGAGAAGGGAGTGGGAAGCTCGAAGGAGAGAGATTATTTTTGACTATGAGCAATATGAATACCATGGAACATCATCTGCAATGATGATGTTTGAGTTGGCTTGGATTATGTCTAAGGATTCAAATGATATGTTATGGTGGGCAATTGTTGGTCTGACAGATCAATGGGTTCAGGACCGAATAACTCAAATGAAATATGTGACAGATGTGGGAACCCTCCAGCGCCATGTTTCCAGGCACAACCACCGTAATGAGGATGAAGAGAATTCGCTCTCTATTGACTGCATGAGGATAGCATTTGAATACGATCTGCGTCTTTCTCTGTATCAGCATTGGTCCTTGTATGAAAGCATCTGTAACTCCTGTTATACATCTGCCACTCTCAAGCTATGGTCTCTGCAAGGGCAGAAAAAACTTCAAGAATTTCTTGCAGACATGGGGATGCCTCTGAAGCAAGTAAAACAAAAGTTCAATTCTATGGACATATCCTTAAAGGAAAATCTTCGGGAAATGCTTGAGGAGTCGGCGAATAAATTTGGAATGAAAGATGTGAGGGTGCAGACCTTTAGTGTACAGTTTGGGTTTAAGAACAAGTTTCTGGCCAGTGACATAGTCTTTGCTGTGCTTTCTCTCCTGGAAAACACTGAACGAGATGAGAAGGGTACAGATAATTTTATCAAGGCCTTGGATAGCCTCTCCAGGAGTAACCTGGATAAACTGCACACTGGCCTGGAAATGGGCAAAAAGCTTTTATGTGCTATTCAACAGACAGTGGCCAGCTGCATCTGCACAAATCTCATATTGTCCCAGGGCCCCTTCCTTTACTGTTACCTGATGGAGGGGACACCAGATGTTAAGATGTTTTCCAATCCAATTTCTCTCTGCCTGCTCTGTAAATACTTGCTGAAGTCCTTTGTGTGTTCTACCAAAAACAAACGGTGTAAGTTGCTACCGCTGGTGTTGGCAGCTCCTCTGGATGCAGAGAAGGGGACCGTGATCATGGTGGGAATTCCCCCTGAAGCAGAGAGCTCTGACAAGAAGAATTTCTTTGGCCGAGCATTTGAGAAAGCAGCAGAGAGCACAAGTTCTCGGACACTTCACAACCATTTCGACATGTCCATAATTGAGTTAAGGACAGAGGACCGCAGCAAGTTCCTGGATGCTCTTATTTCTCTATTGTCATGAGTAATCCATGGCCCTTTTTTTTTTTGTCTGCTTCTTGTCAACACGTGCTGCCGCCTTTTGTATATGTGAATTTTAGCCTCCTGTTTTACAGTGTCTTTTTAAAAAAAAAAAAATATATGTACTGATTAAATTATTTAGCTATAGAAATGAAGCCCAGTGTAATTACATGTTTGTATGGTGCCTGTGTCTAAAACTGTAAATAAAAATTACATTTCTGTTGAAAAAAAAAAAAAAAAAAA
Protein		NCBI Protein >AAI21629|LOC779545 protein [Xenopus (Silurana) tropicalis] LVAPDVDALCACKVLQALFQCDHVQYTLVPVSGWQELETLFLEHKEQFRYFVLINCGANIDLLETLQPQEEAIFYICDTHRPIDVVNIYNDSQIKLLIRQDDDLEIPAYDDIFNDDEDEEDGDDSGNESDGAEPSGKRRRFDEAAVERRIERRRQRREWEARRREILFDYEQYEYHGTSSAMMMFELAWIMSKDSNDMLWWAIVGLTDQWVQDRITQMKYVTDVGTLQRHVSRHNHRNEDEENSLSIDCMRIAFEYDLRLSLYQHWSLYESICNSCYTSASLKLWSVQGQKKLQEFLADMGMPLKQVKQKFNSMDISLKENLREMLEESANKFGMKDVRVQTFSVQFGFKNKFLASDIVFAVLSLLENIERDEKGTDNFIKALDSLSRSNLDKLHTGLEMAKKLLRAIQQTVASCICTNLILSQGPFLYCYLMEGTPDVKMFANPISLCLLCKYLLKSFVCSTKNKRCKLLPLVLAAPLDAEKGTVIMVGIPPEAESSDKKNFFGRAFEKAAESTSSRTLHNHFDMSIIELRTEDRSKFLDALISLLS	Refseq >NP_001081842|cell division control protein 45 homolog [Xenopus laevis] MFVSDLRKEFFDVIVTERVLLLVAPDVDALCACKILQALFQCDHVQYTLVPVSGWQELETLFLEHKEQFRYFVLINCGANIDLLETLQPQEEAIFYICDTHRPIDVVNIYNDSQVKLLIRQDDDLEIPAYDDIFNDDEEDGEDSGNESDGAEPSGKRRRFDEAAVERRIERRRQRREWEARRREIIFDYEQYEYHGTSSAMMMFELAWIMSKDSNDMLWWAIVGLTDQWVQDRITQMKYVTDVGTLQRHVSRHNHRNEDEENSLSIDCMRIAFEYDLRLSLYQHWSLYESICNSCYTSATLKLWSLQGQKKLQEFLADMGMPLKQVKQKFNSMDISLKENLREMLEESANKFGMKDVRVQTFSVQFGFKNKFLASDIVFAVLSLLENTERDEKGTDNFIKALDSLSRSNLDKLHTGLEMGKKLLCAIQQTVASCICTNLILSQGPFLYCYLMEGTPDVKMFSNPISLCLLCKYLLKSFVCSTKNKRCKLLPLVLAAPLDAEKGTVIMVGIPPEAESSDKKNFFGRAFEKAAESTSSRTLHNHFDMSIIELRTEDRSKFLDALISLLS UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.25472 [+] Str.62734	Xl.6393
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		3 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	CDC45
mouse		MGI	Cdc45	All(4) Targeted, knock Out(2) Targeted, other(2)
zebrafish		ZFIN	cdc45	2 Lines(s)

Publications
First:		Xenopus Cdc45-dependent loading of DNA polymerase alpha onto chromatin under the control of S-phase Cdk. [EMBO J 1998]
Most recent:		Evolutionary diversification of eukaryotic DNA replication machinery. [Subcell Biochem 2012]
		View All Papers 1 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:
Biological:		DNA replication initiation regulation of progression through cell cycle
Cellular Component:
EC:
KOG:		[L] CDC45 (cell division cycle 45)-like protein

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.25472.1.A1_at [+] Str.6579.1.S1_at	Xl.6393.1.S1_at
Affymetrix 2.0			Xl2.6393.1.S1_at

Symbol legend[+]

- Blast this sequence
   - Literature Or Expression Images