[provisional- machine annotated only] Gene Symbol: p2rx7 [Predicted: Source is Human Entrez Gene] Gene Name: purinergic receptor P2X, ligand-gated ion channel, 7 [Predicted: Source is Human Entrez Gene] Synonyms: p2x7 Add Xenopus synonyms Gene Function: Interactants: p2rx2(5) , p2rx4(5) , panx1(3) , casp1(1) , dao(1) , p2ry1(1) , pld1(1) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		NCBI Nucleotide >XM_002937699|PREDICTED: Xenopus (Silurana) tropicalis p2X purinoceptor 7-like (LOC100490662), mRNA ATGGCACCAACCTTTGCAGACTGCTTTGATTACTCTACAAAAAAAGAGGTTCGCATACAAAGTGTTCCCCTTGGGGTCCTGAAATGCTGCATTACCTTTGGTGTGATTGTGTTTGTGTGTTTCAGTCTCATCACACAGAAGAGCTACCAGAAAAAGGATTCTGTAATCAGTTCAGTTCACACAAAAGTGAAAGGCTTTGCAAATGCTTATTCCAGGATCTGGGACACGGCAGAATATACAGTCCCATCCCCTGGAGGTGACTCATTTTTTGTTGTAACAAACATAGTTAAAACAGAAAATCAAAGGCAAGATAACTGCTCAGAGCTTCCATCGCAAAAAACAATTTGCTCTCGTGATGATGTTTGTAAAAAAGGCCTTGCAGACCCACAAAGTAATGGGATTCAAACTGGGCGATGTATAAACTTTAACAGTACTTTAAAGACTTGTGAGGTGTCAGCCTGGTGCCCTGTGGAATCACAGACCACTCCAGTTCCTGCTGTTTTGGAAAGTGCTGAAAACTTCACTGTCCTAATAAAGAACAATATACACTTTGCAGCCTTCAATTTCACAAAGAAAAATATTCTACCAAAATATAATGTGTCGTGCATTTATGACCGAGTCAAAGCCCCACTCTGTCCCATATTTCGTTTAGGAGACATTTTAAGGGAAGCTGGAGAGAACTTTTCCCAAGTAGCAGTGCTGGGTGGAGTTATAGGAATTGAAATCAACTGGGACTGTGATCTTGACTCCTTGAGATACAAATGTGAACCTCATTATAGTTTCCGGCGATTGAATAATAAAGTTGTTGATGAACGCTTGTACCCTGGATTAAACTTTAGATTTGCAAGACACTACAAAACTTCAGATGGAAAAGACACAAGGACACTAATAAAGGCATACGGGATTCGATTTGACATTCAAGTCTATGGCACAGGTGGTAAATTTAGTCTGTTTGAACTAGCGATATTTATTGGATCCTGCCTATCTTACTTTGGATGTGCATCACTTGCAATTGATTTCATTATTGGCCTTTACAAACCCTGTTGCTGTAATGCAAAGTCTGTTCTGAAATACTATAATGACAGAAAGTATGAAATGGTCCCTGGACCCGCTGTTCCACTTTGCTTTTCAAAGTCACAACTAAAATTTGTGTCATTTGCGGATGAAGAAGATATTTTGATGGTGGACAACAATTTAAAGGACAGCCTGCAGTTTGCCTCAGGCCGATACATTCAGAGAGAAAGGTTTGCATACACAGAAGCCAACTGTAAGGATTCTCACAAGCAAAATGAAAGTGAAATGAGGCTGATTAAAGGGAGCTCTACCACGTTACCTCCAGCCTGGTGCAAGTGTAACAAGTGCATTGATGTAACACAGCCTGAGGAGCAGTTGTGCTGCAGACTCGGAGAAGGCCAATGTATTACAGACACTAAAATCTTTAACTATTTGGTTTTAAACAAAGAAGCCCTGGAGTACGCTTTCCAGTATGACAATCCTTTATCGAAAACACCAGAGAGCGAAGATCTAAAATGTTACGCTAAGCAAAAATATATTGAGTGGCGTTTTAGATGCAGAAGGTACATGTTAGATTTTGCAGTGATCCCTAGCTGTTGTAAAAATGCAATAGAAACTTGCAATCTGCAAACACAACACCCATCTGGAGCCCTGTACCTACCTCCAACTCACGGCATGTGTTAG	Refseq >NM_001088727|Xenopus laevis purinergic receptor P2X, ligand-gated ion channel, 7 (p2rx7), mRNA GATGTGGAGGAAACAGTGAGGAGACAGGGTAACAGAGAAAGGGGAAATATACAAATTCTGATATAGCAAAAAGCTGTTGATAAGAGAGAATTAGAAGAAGTGGTAGGAAAGGGAGAAAACGAGTGCGGGGCAGAGAGAGAGGACAAAAAGAATGTTTGTAGGGTGGGCTGTTTAAATGAGGTTTTCTGGTGGGCAGATCTTTTGGCTGTTGCCATCACAATAATAAAACAAGCAAAATGTGCTGCAGATAGGACATTCGTACTGTCCTGACACAATGAACAAAGGAGCATTGAGTCAGTCTTCCCTGCTAGCTACATTTCTCATTTGCATCTAAAAAAAAACAGCTGTACCACCAGTGTGATCTGTTAGAAAAGAGTGACATAGGTTGTTCGGGGCTGCATACCTCCCCCTGCATCCTGTCTCAATAATTCATATTGAGTTAGTTTCAGTTCAGCTTTACAGTTGGTGTATGAGGGAAGGAAGCATTGCTGCACACTTAGCCCTTTAGCCCACGTCTGGAGCCCTGCAGAAATGACACTGACCTTAGCAGACTGCTTTGATTATTCTACAAAAAAAGAAGTTCGCATACAAAGCGTTCCCCTTGGGATCCTGAAACAGTGCATTACATTCGGTGTGATTGTGTTTGTGTGCTTCAGCCTCATAACACAGAAGCGCTACCAGAAAAAAGATTCTATTATCAGTTCGGTTCACACGAAAGTAAAAGGCTTTGCAGATGCTCATTCAAGGATCTGGGACACGGCAGAATATACTGTCCCATCCCCTGGCGGTGACTCATTTTTTGTTATAACTAACATAGTTAAAACAGAAGGTCAAATGCAAAGTAATTGTTCAGAGCTTCCAAGCCAAAAAACAATTTGCTCTCGTGATGATATTTGCAAAAAAGGCCTTGCAGACCCACAAAGTAATGGTATCCAGACTGGACGATGTATAAACTTTAACAATACTTTAAAGACTTGTGAGGTGTCAGCGTGGTGCCCTGTGGAGTCACAGACCACCCCAGTTCCTGCTGTTTTGGAAAGTGCTGAAAATTTCACTGTCCTAATAAAGAACAATATACATTTTGCAGCCTTCAATTTCACAAAGAAAAATATTCTACCAAATTATAATGTATCATGCATTTATGACCGAGTCAAAGCACCTCTCTGTCCCATATTTCGTTTAGGAGACATTTTAAGGGAAGCTGGAGAAAACTTTTCCCAAGTAGCAGTATTGGGTGGAGTAATAGGCATTGAGATCAACTGGGACTGTGATCTCGATCCCTTGAGATACAAATGTGAACCTCATTACGGTTTCCGACGATTGGATGATACAGTTGTTGATGAAAGCTTGTATCCTGGATTAAACTTTAGATTTGCAAGATACTACAAAAATGCACATGGAACAGAGACAAGGACCCTAATAAAGGCATATGGAATTCGATTTGACATCCAAGTCTATGGCACGGGAGGTCAATTTAATTTATTAGAACTAGCGTTATTTATTGGATCCTGTCTATCTTACTTTGGATGTGCTTCCTTTGCAATTGATTTCATCATTGGCCGGTATAATTCTTGCTGCTGTAACGCAAAGTCAGTTCTAAAATACTATGATGACAGAAAGTATGAAACAATCCCAGGACCCTCAGTTTCACTGGCACACCTAAAAGCACACCTAAAATTTGTGTCATTTGTGGATAAAGAAGATATTTTGATGGTGGACCAGAAATTAAAGGGTAGCTTGCAGTTAGCTTCGGGCCCATATATCCAGAGAGAAAGATTTGCAGACACAAAAGCCAAATGTAAGGATTCTCACAAGCAAGATGAAAATGAAATGAGGCTAATAAAAGGGAGATCTGCTATGCTGCCTCCTGCCTGGTGCAAGTGTAACAAGTGCATTAATACAACACATCTTGAGGAGCAGTTGTGCTGCAGACTTGAAGAGGGAGAATGTATTACAGATACTAAAATGTTTAACTCCCTGGTTTTGAACAGAGAATCTTTGGAATATGCTTTCCAGTATGACAATCCTTTATCGAAAACACCAATAAGCAAAGAGCATCTAAGATATTATGCTAAGCAAAAATATGTTGAGTGGCGTTTTGGATGCAGAAAGTATATGTTAAATTTTGCAGTGATCCCCAACTGCTGTAAAACTGCAATAGAAACTTGCAACCTGCAAACAGAAGGCCCATAAGGAACCCTGTATTTGCTTCCTGCTCATGGCATGCGGTAGATACAGGATTCCCTTGAACAAGTGACTGCTATAGTCTGTGTCTTTACTGCTTTCACATATACAGTATACTAATACCAGAAAATGTTGATATACTGCATATGCGCAAGTCTAGATCTACACAAGGGTTTCCTGGTAAATACAGGTAACATGATGGCAGTAGGAAGCTTTTACTGAAAGACATAAAGAAGAGCACTAGCTAAGGGGGAAAAATCCCTTTATTCACTGAGAAGTGTCTGACAATTGCCCCACAGTGATTTAGCCTTTTCTGGTTCTGGTTATATTGGGGTGAAGGCTGCCACAGTAAGCAGGGAAAGAAATATTCAAAATTGGCCATACATGGGCTGTTAAAATTTGGTGACTTGACCCTTCCAGACAAAGTGCCAAGTGGTTATTGGCCCATGTATGGGTCCCTCCAATATGCCTGCCCAACTGATATCTGGGCAAAAATATGGTTGGGACAAGGACCACATTGACTCCTTTATGTAGTCCTCACCCAGATGATCTGTTGAAGACCATCTGAAATTGTGCTTAGAATAGGTCCAGCTGTAACCAGAGGCGAATTAAGCATGCAATTGCACTCTCTGCAATAACGATGCAGCTCCCCTTGACCTGCACAGACGCTCCAAATGTTAGGTGGGGGGATGGGCAGCATTAGCAAACTGCCCCTGGCTATAACTTATAAAGTGAACTTCCCATTAAGAAAGTTAGCAGTCTGATTTTATGTGGCCCTACATGGGCAAATTTAAGATGCTGATTTGGGTCCTTTAGAGACGATCCAGCAGCTTATTTGCCGTGTATAGGGCTTTTTCGACAGGCCTCCCTGGCCGATATTTGACCAAAATCAGCCAGATATCCATCGAGCAAGTTTGATTTTTCACTCCGATCGAGGACTGCATCAGCTAGTTGATGCGGTCCCTGCCCATTGGTGCCTATTCCCATCATTGTAATCCAATCGTTTAGCCCTAGGTCTGAATGATTGGATTAGCCTTTGGTGGGCATATCTGAGGAAAGATCTGCTAGTTTGGCAATCTTAAAGTGTATGGCCACCTTTACTGACCTGCTCAATACTGTAGGTTTTGTGAAAATTAAATTCTCTTCCTTAACTAAAAACTCTCAGAGAATCAGTTTTATCTGCTTGAGGTATAATGCTCTATAGATAAATGTATATATTCTGTGTCAGAGGAATTCCGGGAAAAAAAAAAATATATATATATATACATATATATATATACATATCAAAACAGGAGGGTTGTGGGAGCACTCTAAAGGCTTTAAAGTATATATAGATAAGTATAATAAATGCTATTGCATATGTACCCAAACAGGGGTTATTTTGTTACAAAGTTATGATCATAAAATTGATAAGCCACCATACCACGTCAAGGTAAACCCCGAATGGCGGTCCCTAACTTGTTTTATTTTTTATGTGCATTCTAGCATTACCTATAATCAATGTCCGTTGAATGCTGTTTTTTCACCGAGGGCTAAATCCTCCCCAGCCCCTACCCACTGGTCAAATGCTGCATCAACAGATTATATTTTGAAACTTGGCTGATCCCCTATCAATAGTACCTGGATATCGGTCTTGATCAGTGGGCCCGCATAAACCCAAAGAATATCATAGGAAAATATTTGATCTGTGCTTATATGGCTACCTTAAGAAGTCTAGTCATTTATCTTGGCTTTAGTTGTCCTATAAACAAATCCCTTAGCAAACCCTGTCTTTTAAAACAATAAGCATATGTGTTAAAGAGGGTAGAAAGTACAAGACAAACACACCTTAGGGACAAAGCACTCACTTTTATTTTTCCTGGGATTCTCAGGCTGCAATATGTACTTGTATCACTTCACTGCATCTCTGGGATATTCGTTATTTGGTAACACCCAAGTTAGTCTTCTTTCCCTCCCTTGTTAAATTTATTGGGCACAAGGGTTTATGTATTTGTTCCATATTGCAGAAGAATGTCAATAGACCCTAGTTTACTGACATAATACTGTTTCTCAGGCTTGTCATACAATGGGCAGTGGGCCAGTCGCTTTCTTTGCCTGAAGGAGTTTACCATCCCATAGAATAGTGCTGGGGGCTCCAGTAACCATGCACTGTTTGGATTCACTGTAAATATGTTAAACTTGCATAATATATGATTAAAAAAAAGTCTTACCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Protein		NCBI Protein >XP_002937745|PREDICTED: p2X purinoceptor 7-like [Xenopus (Silurana) tropicalis] MAPTFADCFDYSTKKEVRIQSVPLGVLKCCITFGVIVFVCFSLITQKSYQKKDSVISSVHTKVKGFANAYSRIWDTAEYTVPSPGGDSFFVVTNIVKTENQRQDNCSELPSQKTICSRDDVCKKGLADPQSNGIQTGRCINFNSTLKTCEVSAWCPVESQTTPVPAVLESAENFTVLIKNNIHFAAFNFTKKNILPKYNVSCIYDRVKAPLCPIFRLGDILREAGENFSQVAVLGGVIGIEINWDCDLDSLRYKCEPHYSFRRLNNKVVDERLYPGLNFRFARHYKTSDGKDTRTLIKAYGIRFDIQVYGTGGKFSLFELAIFIGSCLSYFGCASLAIDFIIGLYKPCCCNAKSVLKYYNDRKYEMVPGPAVPLCFSKSQLKFVSFADEEDILMVDNNLKDSLQFASGRYIQRERFAYTEANCKDSHKQNESEMRLIKGSSTTLPPAWCKCNKCIDVTQPEEQLCCRLGEGQCITDTKIFNYLVLNKEALEYAFQYDNPLSKTPESEDLKCYAKQKYIEWRFRCRRYMLDFAVIPSCCKNAIETCNLQTQHPSGALYLPPTHGMC	Refseq >NP_001082196|purinergic receptor P2X, ligand-gated ion channel, 7 [Xenopus laevis] MTLTLADCFDYSTKKEVRIQSVPLGILKQCITFGVIVFVCFSLITQKRYQKKDSIISSVHTKVKGFADAHSRIWDTAEYTVPSPGGDSFFVITNIVKTEGQMQSNCSELPSQKTICSRDDICKKGLADPQSNGIQTGRCINFNNTLKTCEVSAWCPVESQTTPVPAVLESAENFTVLIKNNIHFAAFNFTKKNILPNYNVSCIYDRVKAPLCPIFRLGDILREAGENFSQVAVLGGVIGIEINWDCDLDPLRYKCEPHYGFRRLDDTVVDESLYPGLNFRFARYYKNAHGTETRTLIKAYGIRFDIQVYGTGGQFNLLELALFIGSCLSYFGCASFAIDFIIGRYNSCCCNAKSVLKYYDDRKYETIPGPSVSLAHLKAHLKFVSFVDKEDILMVDQKLKGSLQLASGPYIQRERFADTKAKCKDSHKQDENEMRLIKGRSAMLPPAWCKCNKCINTTHLEEQLCCRLEEGECITDTKMFNSLVLNRESLEYAFQYDNPLSKTPISKEHLRYYAKQKYVEWRFGCRKYMLNFAVIPNCCKTAIETCNLQTEGP

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene			Xl.5033
Unigene EST Profile			EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	P2RX7	OMIM:151400
mouse		MGI	P2rx7	All(8) Targeted, knock Out(4) Spontaneous(1) Targeted, other(3)
zebrafish		ZFIN	p2rx7

Publications
First:		P2X7 purinoceptor expression in Xenopus oocytes is not sufficient to produce a pore-forming P2Z-like phenotype. [FEBS Lett 1997]
Most recent:		P2X4 receptor channels form large noncytolytic pores in resting and activated microglia. [Glia 2012]
		View All Papers

Functional Ontologies
GO: Molecular:		ATP binding ion channel activity receptor activity
Biological:		ion transport
Cellular Component:		membrane
EC:
KOG:

Reagents		tropicalis	laevis
Clones			open biosystems
			geneservice/RZPD imagenes
Affymetrix 1.0		StrJgi.3512.1.S1_at [+] StrJgi.3512.1.S1_s_at	Xl.5033.1.S1_at
Affymetrix 2.0			Xl2.5033.1.S1_at

Symbol legend[+]

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