pik3ca Summary [species: Xenopus laevis and Xenopus tropicalis]

Summary

Expression

XB-GENEPAGE-998105

[provisional- machine annotated only]

Gene Symbol: pik3ca [Predicted: Source is Human Entrez Gene]

Gene Name: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha [Predicted: Source is Human Entrez Gene]

Synonyms: pi3k, PI3K-alpha, PI3-kinase, pi3-k Add Xenopus synonyms

Gene Function: phosphoinositide-3-kinase

Interactants: pik3cb(37) , pik3cg(37) , mapk1(23) , akt1(22) , ins(13) , slc1a1(8) , igf1(7) View All

XB-GENE-998106

XB-GENE-998109

Molecules	tropicalis	laevis
Gene	JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
	Entrez Gene	Entrez Gene
mRNA	Refseq >NM_001126500\|Xenopus (Silurana) tropicalis phosphoinositide-3-kinase, catalytic, alpha polypeptide (pik3ca), mRNA GGATTAGCTGTCAGGCTGGAGCCAAAGAGCTACACATTAATGGCGATGCGGGACGTTTAAGCAGCGATACGGGACTGTGGGTTTTATTAAGAAAATCAAGTGCCCCACGAAAAGTGAGGCTGTTGGGCAGTATGCGGCTGGGGGTTCCACATGTACGCATACAAGAATAATGCAATTTTATGACATCTAAAACTTTATTTGAGAAGGAAGACGCAGTTACGTAATCATGCCGCCAAGACCTTCCTCTGGTGAACTATGGGGCATCCATTTGATGCCCCCAAGAATTCTAGTGGAATGCCTATTACCAAATGGAATGGTGGTGGTTTTAGAATGTCTTCGCGAAGCGACCCTTGTGAATATCAAACATGAGCTCTTTAAAGAGGCCCGAAAGTACCCACTTTACCATCTACTCCAAGATGAGTCCTCTTATATTTTTGTGAGTGTTACCCAGGAAGCAGAAAGAGAAGAATTTTTTGACGAGACCCGCCGCCTCTGTGATCTTCGACTGTTCCAACCTTTCTTGAAAGTAGTTGAGCCTGTTGGAAACAGAGAAGAGAAAATACTTAATCGAGAAATCGGCTTTGCCATTGGAATGCCAGTTTGCGAATTTGATATGGTAAAGGATTCAGAGGTTCAGGATTTTAGAAAAAATATCCTTAATGTTTGTAAAGATTCAGTTGAACTTCGTGATGCTAATGGACCGATCAGCAGAGCATTGTATGTTTACCCACCTAATGTAGAGTCCTCTTCAGAGCTTCCCAAACACATAGAAAGCAAGCTAGATAAAGGGCAAATAATTGTGGTCATATGGGTCATTGTATCTCCTAACAATGAAAAGCAGAAGTATTCTTTGAAGATAAACCATGATTGTGTGCCAGAACATGTAATAGCTGAAGCTATCAGGAAGAAAACAAGGAGCATGCTACTGTCGTCAGAACAGCTAAAGCTTTGCGTTCTAGAGTACCAAGGAAAATACATCTTGAAAGTTTGTGGATGTGATGAGTATTTGTTGGAAAAGTATCCATTGAGTCAGTATAAGTATATAAGAAGCTGTATAATGCTTGGTCGGATGCCTAATTTAATGTTAATGGCTAAAGATAGCCTGTACAGTCAAATTCCAGTGGATGTATTTACAATGCCATCGTATTCAAGGAGGATTTCCACAGCAGCACCATACATGAACGGAGAAGCTTCAGCCAAGTCATTGTGGGCAATCAACAGTACTCTTAGAATAAAAATCCTTTGTGCCACATATGTCAATGTAAACATTCGAGACATTGATAAGATTTATGTTCGAACTGGCATCTATCATGGAGTTGAGCCATTATGTGACAATGTTAACACTCAGAGGGTGCCTTGTTCAAATCCAAGATGGAATGAATGGCTTTTATATGATATGTTCATTCCTGATTTACCCCGAGCTGCGCGGCTTTGCCTCTCCATCTGCTCCGTAAAGGGAAGGAAGGGTGCCAAAGAAGAGCACTGCCCTTTAGCTTGGGGAAACATAAACCTGTTTGACTACACAGATACTCTGGTGTCTGGCAAAATGGCTCTAAATTTGTGGCCTGTACCTCATGGGCTAGAGGACTTGTTAAATCCTATTGGAGTGAGTGGCTCCAATCCTAATAAGGAAACGCCCTGTTTGGAACTAGAATTTGACTGTTTCAGTAGCCCGGTCAAATTTCCTGATATGACAGCAATAGAAGATCATGCAAATAAAGTTCTGGAACGAGAAATGGGCTATAATTACAGCCATTCTGGACTGAGTAACAGAATTGTTAGAGAAAATGAAGTAAGAGAAAGTGACAAAGAGCAGCTCAAAGCCATTTCTAATCGTGACCCTCTTTCTGAAATTACTGAACAAGAAAAAGAATTCCTTTGGAGCCACAGACTTTATTGTCGAAATATACCTGAAATTCTTCCTAAGCTGCTTCTGTCTGTGAAATGGAATTGCAGAGATGATGTTTCACAGATGTATTGTCTTTTAAAAGAGTGGCCTGCCATCCGGCCAGAACAAGCAATGGAACTGTTGGATTTTAATTACCCAGATCGGATTGTAAGATCATTTGCGGTTTCTTGCCTTGAGAAGTATTTGACAGATGATAAGCTGTCGCAGTATTTGATTCAACTTGTGCAGGTTATGAAATATGAGCAGTACTTGGACAACCATCTAGTTAGATTTCTGCTGAAAAAGGCTCTGGTCAATCAAAGAATAGGACATTTCTTTTTCTGGCTTTTAAAGTCAGAAATGCACAACAAAACTGTCAGCCAAAGGTTTGGTCTTTTGCTGGAATCCTATTGCCGTGCATGTGGAATGTATTTAAAGCATTTAAGTAAGCAGGTGGAAGCTATGGAAAAACTGATCAACCTCACAGATATTCTAAAGCAGGAGAAGAAGGATGAGACACAAAAGGTGCAAATGAAGTTCCTGGTTGAACAAATGAAGCGGCCAGATTTTATGGATGCATTGCAAGGATTTACGTCTCCTCTGAATCCTGCTCACCAGTTGGGAAACCTCAGGCTTGAAGAATGCAGGATAATGTCATCTGCAAAAAGACCACTGTGGTTAAACTGGGAAAATCCAGATATTATGTCAGAGATGCTGTTTTTGAATAATGAGATCATCTTTAAAAATGGCGATGATTTACGACAAGATATGCTCACGCTTCAGATCATAAGAATCATGGAAAACATTTGGCAAAATCAGGGCCTTGATTTACGGATGTTGCCGTATGGTTGCCTGTCAATCGGGGATTGTGTTGGACTTATTGAAGTAGTAAGGTGTTCACATACCATTATGCAGATTCAATGCAAAGGAGGTTTGAAAGGAGCATTGCAGTTCAACAGTCACACATTGCACCAGTGGCTCAAGGATAAAAACAAGGGTGAAACGTATGATGCTGCCATTGATCTATTCACTCGATCGTGCGCTGGTTACTGTGTTGCAACTTTTATTCTTGGAATAGGTGATCGCCATAACAGTAACATTATGGTTAAAGACAATGGGCAACTGTTTCACATAGATTTTGGCCACTTTCTGGATCACAAAAAGAAGAAATTTGGCTATAAACGTGAAAGGGTACCGTTTGTCTTGACTCAAGATTTTCTGATTGTGATCAGCAAGGGAATTCAAGAATGCACGAAAACCAGGGATTTTGAGAGATTTCAAGAGATGTGTTACAAAGCTTACTTAGCAATCCGTCAGCATGCCAACCTTTTCATCAACTTGTTCTCTATGATGCTTGGCTCTGGAATGCCTGAACTGCAATCTTTTGATGATATTGCATATATTCGAAAAACATTAGCATTGGATAAAACTGAACAAGAGGCTTTGGAATACTTCATGAAGCAGATGAATGACGCACATCATGGTGGCTGGACAACAAAAATGGACTGGATCTTCCATACAATAAAGCATCTTTAAACCGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA	NCBI Nucleotide >AF204924\|Xenopus laevis phosphoinositide 3 kinase catalytic subunit mRNA, partial cds GATGAAACACGACGACTTTGTGATCTTCGACTGTTCCAACCTTTCTTGAAAGTAGTTGAGCCTGTAGGAAACCGAGAAGAGAAAATCCTTAATCGAGAAATTGGCTTTGCCATTGGAATGCCGGTATGTGAATTTGATATGGTTAAGGATTCGGAGGTTCAGGACTTTAGGAAAAATGTCCTAAATGTTTGCAAAGATTCAGTCGAACTTCGTGATGCTAATGGGCCGATCAGCAGAGCGTTGTATGTTTACCCACCTAATGTAGAATCCTCTTCAGAGCTTCCCAAACACATAGAAAGCAAACTAGATAAAGGGCAAATAATTGTGGTCATATGGGTCATTGTATCTCCTAACAACGAAAAGCAGAAGTATTCTTTGAAGATTAACCATGATTGTGTGCCAGAACATGTAATCGCTGAAGCTATCAGGAAGAAACCAAGGAGTATGCTACTGTCAACAGAACAGCTAAAGCTTTGTGTTCTGGAGTACCAAGGAAAATACATTTTGAAGGTCTGTGGATGTGATGAGTATTTGTTGGAAAAATATCCACTGAGTCAGTATAAGTATATAAGAAGTTGTATAATGCTTGGTCGGATGCCTAATTTAATGTTAATGGCCAAAGAGAGCCTGTACAATCAAATTCCAGTGGATATATTTACCATGCCATCTTATTCAAGGAGGATTTCCACAGCAGCACCATACATGAATGGAGAAACTTCAGCCAAGTCATTGTGGGCAATCAACAGTACTCTTAGAATAAAAATCCTTTGGGCCACATATGTCAATGTAACCATTCGAGACATTGATAAGATCTATGTTCGAACTGGAATCTATCATGGAGTTGAGCCATTATGTGACAATGTTAACACTCAGAGGGTGCCTTGCTCAAATCCAAGATGGAATGAATGGCTTTTATATGATATGTTCATTCCTGATTTACCACGAGCTGCACGAGTTTGCCTCTCCATTTGTTCCGTAAAGGGACGGAAGGGTGCCAAAGAAGAGCACTGCCCTTTAGCATGGGGAAATATAAACCTGTTTGACTACACAGATACACTGGTGTCTGGAAAAATGGCTCTAAATTTGTGGCCTGTACCTCACGGTTTAGAAGACTTGCTAAATCCTATTGGAGTTAGTGGCTCCAATCCTAACAAGGAAACACCCTGTTTGGAACTAGAATTTGACTGTTTCAGTAGCCCAGTCAAATTTCCTGATATGACCGCAATCGAAGATCATGCAAATAAAGTTCTGGAGCGAGAATTGGGCTATAATTACAGCCATTCTGGACTGAGTAACAGAATTGTTAGAGAAAATGAAGTAAGAGAAAATGACAAAGAGCAGCTCAGAGCCATTTCTAACCGTGACCCTCTTTCTGAAATTACTGAACAAGAAAAAGAATTCCTTTGGAGCCACAGACTTTATTGTCGAAACATACCTGAAGTTCTTTCTAAGCTTCTTCTGTCTGTGAAATGGAATTGCAGAGATGATGTTTCACAGATGTATTGTCTTCTAAAAGAGTGGCCTGCTATCCGGCCAGAACAAGCAATGGAACTGTTGGATTTTAATTACCCAGATCGGATTGTACGCTCATTTGCCGTTTCTTGCCTTGAGAAGTATTTGACAGATGATAAGCTATCGCAGTTTTTGATCCAACTTGTGCAGGTTATGAAATATGAGCAGTACTTGGACAACCATCTAGTGAGATTTCTGTTGAAAAGGGCTCTGGTCAATCAAAGAATAGGACATTTCTTTTTCTGGCATTTAAAGTCTGAAATGCACAATAAAACGGTCAGCCAGAGGTTTGGTCTTTTGCTGGAATCCTATTGCCGTGCATGTGGAATGTATTTAAAACATTTAAGTAAGCAGGTGGAGGCAATGGAAAAACTGATCAACCTCACAGATATTCTAAAGCAGGAGAAGAAGGATGAGACACAAAAGGTGCAAATGAAGTTCCTGTTTGAACAAATGAAGCGGCCAGATTTTATGGATGCGTTACAGGGATTTACGTCTCCTCTAAATCCTGCTCACCAATTAGGAAACCTCAGGCTTGAAGAGTGCAGAATAATGTCATCTGCAAAAAGACCACTCTGGTTAAGCTGGGAAAATCCAGATATCATGTCAGAGATGCTGTTTTTGAATAATGAGATCATCTTTAAAAATGGAGATGATTTACGACAAGACATGCTTACGCTCCAGATCATAAGAATCATGGAAAACATTTGGCAAAATCAAGGCCTTGATCTACGGATGTTGCCGTATGGATGCCTGTCAATTGGGGACTGTGTAGGACTTATTGAAGTAGTGAGATGCTCACATACCATTATGCAGATTCAGTGCAAAGGAGGTTTGAAAGGAGCGTTGCAGTTCAACAGTCACACATTGCATCAATGGCTCAAGGATAAAAACAAGGGTGAAACATACGATGCCGCCATCGACCTATTCACTCGATCGTGTGCCGGTTACTGTGTTGCAACTTTCATTCTTGGAATAGGTGATCGGCATAACAGTAACATTATGGTTAAAGACAGTGGGCAGCTCTTCCACATAGATTTTGGG
Protein	Refseq >NP_001119972\|phosphoinositide-3-kinase, catalytic, alpha polypeptide [Xenopus (Silurana) tropicalis] MPPRPSSGELWGIHLMPPRILVECLLPNGMVVVLECLREATLVNIKHELFKEARKYPLYHLLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVVEPVGNREEKILNREIGFAIGMPVCEFDMVKDSEVQDFRKNILNVCKDSVELRDANGPISRALYVYPPNVESSSELPKHIESKLDKGQIIVVIWVIVSPNNEKQKYSLKINHDCVPEHVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYLLEKYPLSQYKYIRSCIMLGRMPNLMLMAKDSLYSQIPVDVFTMPSYSRRISTAAPYMNGEASAKSLWAINSTLRIKILCATYVNVNIRDIDKIYVRTGIYHGVEPLCDNVNTQRVPCSNPRWNEWLLYDMFIPDLPRAARLCLSICSVKGRKGAKEEHCPLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVSGSNPNKETPCLELEFDCFSSPVKFPDMTAIEDHANKVLEREMGYNYSHSGLSNRIVRENEVRESDKEQLKAISNRDPLSEITEQEKEFLWSHRLYCRNIPEILPKLLLSVKWNCRDDVSQMYCLLKEWPAIRPEQAMELLDFNYPDRIVRSFAVSCLEKYLTDDKLSQYLIQLVQVMKYEQYLDNHLVRFLLKKALVNQRIGHFFFWLLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLSKQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQMKRPDFMDALQGFTSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSEMLFLNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRCSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGETYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDNGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGIQECTKTRDFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKHL	NCBI Protein >AAF15300\|phosphoinositide 3 kinase catalytic subunit [Xenopus laevis] DETRRLCDLRLFQPFLKVVEPVGNREEKILNREIGFAIGMPVCEFDMVKDSEVQDFRKNVLNVCKDSVELRDANGPISRALYVYPPNVESSSELPKHIESKLDKGQIIVVIWVIVSPNNEKQKYSLKINHDCVPEHVIAEAIRKKPRSMLLSTEQLKLCVLEYQGKYILKVCGCDEYLLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYNQIPVDIFTMPSYSRRISTAAPYMNGETSAKSLWAINSTLRIKILWATYVNVTIRDIDKIYVRTGIYHGVEPLCDNVNTQRVPCSNPRWNEWLLYDMFIPDLPRAARVCLSICSVKGRKGAKEEHCPLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVSGSNPNKETPCLELEFDCFSSPVKFPDMTAIEDHANKVLERELGYNYSHSGLSNRIVRENEVRENDKEQLRAISNRDPLSEITEQEKEFLWSHRLYCRNIPEVLSKLLLSVKWNCRDDVSQMYCLLKEWPAIRPEQAMELLDFNYPDRIVRSFAVSCLEKYLTDDKLSQFLIQLVQVMKYEQYLDNHLVRFLLKRALVNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLSKQVEAMEKLINLTDILKQEKKDETQKVQMKFLFEQMKRPDFMDALQGFTSPLNPAHQLGNLRLEECRIMSSAKRPLWLSWENPDIMSEMLFLNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRCSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGETYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDSGQLFHIDFG

Genomic	tropicalis
Genome Browser	Xenbase	Xenbase JGI Ensembl UCSC	Xenbase

Synteny	Metazome

Expression	tropicalis	laevis
UniGene	Str.41031 [+] Str.60126	Xl.21527
Unigene EST Profile	EST Profile	EST Profile
GEO data		GEO
Images	0 expression image(s) for tropicalis and laevis

Orthology	MOD	Entrez Gene	Genetic Phenotypes	Morphants
human	OMIM:Gene, HGNC	PIK3CA	OMIM:137215 OMIM:114550 OMIM:114500 OMIM:114480 OMIM:211980 OMIM:604370 OMIM:162900 OMIM:182000
mouse	MGI	Pik3ca	All(14) Targeted, knock Out(3) Targeted, other(8)
zebrafish

Publications
First:		Embryonic mesoderm cells spread in response to platelet-derived growth factor and signaling by phosphatidylinositol 3-kinase. [Proc Natl Acad Sci U S A 1996]
Most recent:		Progesterone increases the activity of glutamate transporter type 3 expressed in Xenopus oocytes. [Eur J Pharmacol 2013]
		View All Papers 5 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		1-phosphatidylinositol-3-kinase activity inositol or phosphatidylinositol kinase activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity More[+] phosphotransferase activity, alcohol group as acceptor
Biological:		signal transduction
Cellular Component:		phosphoinositide 3-kinase complex
EC:		phosphatidylinositol-4,5-bisphosphate 3-kinase
KOG:		[T] Phosphatidylinositol 3-kinase catalytic subunit (p110)

Reagents	tropicalis	laevis
Clones	open biosystems	open biosystems
	geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0	StrJgi.76.1.S1_s_at [+] Str.41208.1.S1_s_at Str.28478.1.A1_at Str.41031.1.S1_at StrEns.156.1.S1_s_at	Xl.21527.1.S1_at [+] Xl.21527.1.A1_at
Affymetrix 2.0		Xl2.21527.1.A1_at [+] Xl2.21527.1.S1_at

Symbol legend[+]