The gene tp53inp2 is present in both Xenopus laevis and Xenopus tropicalis genomes. The protein functions as a regulator in the p53 signaling pathway. It localizes to the nucleus and contains a p53-bin...[+]

The gene tp53inp2 is present in both Xenopus laevis and Xenopus tropicalis genomes. The protein functions as a regulator in the p53 signaling pathway. It localizes to the nucleus and contains a p53-binding domain. The protein interacts with p53 to modulate apoptosis and cell cycle progression. Expression occurs in various tissues during embryonic development and in adult organs. The protein contains a conserved p53-binding domain and nuclear localization signals. It functions as a transcriptional co-regulator in DNA damage response pathways. The protein shows conserved structure and function between the two species. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD