The uba3 gene encodes a protein that functions as an E1-like enzyme in the neddylation pathway, facilitating the conjugation of NEDD8 to cullin-RING ubiquitin ligases, which regulates protein degradati...[+]

The uba3 gene encodes a protein that functions as an E1-like enzyme in the neddylation pathway, facilitating the conjugation of NEDD8 to cullin-RING ubiquitin ligases, which regulates protein degradation and cell cycle progression. It is involved in embryonic development and cell cycle regulation in Xenopus laevis and Xenopus tropicalis. The protein is localized in the nucleus and cytoplasm, and is expressed in various tissues including oocytes and embryos. [-]

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