sgk1 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Summary

Gene Literature (123)

Nucleotides (485)

Interactants (114)

XB-GENEPAGE-1003517

Gene Symbol: sgk1 Gene Name: serum/glucocorticoid regulated kinase 1 Synonyms: Sgk Add Xenopus synonyms Gene Function: serine/threonine kinase Interactants: nedd4(33) , nedd4l(31) , sgk3(28) , akt1(24) , sgk2(19) , ins(18) , ptk2b(17) View All

XB-GENE-1003518

XB-GENE-1003523

XB-GENE-6254615

Molecules		tropicalis	laevis a		laevis b
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene		Entrez Gene
mRNA		Refseq >NM_001030422\|Xenopus (Silurana) tropicalis serum/glucocorticoid regulated kinase 1 (sgk1), mRNA GGTTAATAAGCTAGCTGGCAGCTCCGCACAGGCTCCTTTCCCCACAGAGAGGATCACATTCAGCCCTTTGTGGGGGAGGAGGACTGACTGGCACCTTGTGGATACCATTACTGCCAGTCAATAGCTGCACACCAGGATGAGAACTAAAAACGAAAAATCTCCTCTAAAAGCTTTTATGAAACAACGAAGAATGGGGCTGAATGATTTTATCCAAAAAATTGCAACCAACTCTTCTTACGCCTGTAAACACTCTGAAGTGCAGTCAATCCTGAATATCTCACCGCCCCAAGAACCAGAATTACTGAATGAAAATTCATCTCCTCCTCCTAGCCCTTCTCAGCAGATTAACCTTGGTCCTTCATCCAACCCTCATGCTAAACCATCTGACTTCCAGTTTCTAAAAATCATTGGCAAGGGTAGCTTTGGAAAGGTTCTCCTGGCAAGACATAATGCAGATGAGAAATTCTATGCAGTGAAAGTGCTTCAGAAAAAAGCCATTCTTAAAAAGAAAGAGGAGAAACACATAATGTCAGAGCGCAATGTACTGTTAAAAAATGTGAAACACCCTTTCCTGGTTGGACTCCACTTCTCTTTCCAGACAACTAGCAGACTGTATTTTATTCTGGACTACATCAACGGTGGAGAGTTGTTCTACCATCTTCAGAGAGAACGATGCTTCTTGGAACCTAGAGCTCGTTTTTATGCCGCTGAAATAGCCAGTGCACTAGGATACTTGCACTCTCTCAACATTGTTTATCGTGACTTGAAGCCAGAAAACATTTTGTTGGATTCCCAGGGCCACATTATTCTGACTGATTTTGGCCTTTGCAAGGAGAACATAGAGCCCAATGGCACCACATCTACCTTTTGTGGCACTCCCGAGTATCTTGCACCAGAAGTTTTACACAAACAGCCTTATGACAGAACAGTTGACTGGTGGTGCCTGGGAGCAGTGTTGTACGAGATGCTGTATGGCCTGCCTCCTTTCTACAGTAGAAACACTGCAGAAATGTATGACAATATCTTGAACAAGCCACTGCAGCTAAAACCAAACATAACCAACTCAGCCAGGAACCTCCTGGAGGGTCTTCTGCAGAAGGACCGAACAAAAAGGATTGGTGCGAAGAATGACTTTATGGAGATTAAGAACCACATGTTTTTCTCTCCAATTAACTGGGATGATCTGATTAATAAGAAGATTACACCTCCCTTTAACCCAAATGTGAGTGGGCCAAGTGACCTGCAGCACTTTGATCCGGAATTTACTGAAGAGCCCGTCCCTAATTCTATTGGCCAGTCTCCGGATAGCATCCTCATAACTGCCAGCATTAAAGAAGCTGCAGAAGCATTCATGGGCTTTTCTTATGCACCACCTATGGAATCATATCTTTGAGCAATCCTTCTTTCTCGTCTAGTAGTCATTTCTAATCAAGTCACTTTGATTTTTATTTCCTTTTGATGAAATTTGCACATCCTTCACAACAGCATCACAGCCTTAATTTCAACATCCCTGGTATTGCTGGAAGGGACGAATCAGTGGAGCTGAGAAAAGGATAGAAAAAAGTGACTTTGGACTTCATACTCTGTTGTTGGGAGAAATAAGAACTATTTGCTGAATTTGCAGCATACAACCCTTATATTATACAGAGGGATACATGAGGGCTTCTTAAGCTGGAAGAAGACATCCAAGTGTGTCTTTATAGTATGGGGCTTTTGCAACGTGCCTTTCTCTTTTGAGAGATCTTGTCTATCATAAGAACCATCCATATGACGTGGGGGCTCTTTGGTTTTGACAGTGGTTTTACAAGTGAACAATGGTATGGGTGTAAAGCTTATCACAGTAAAACTGTGGTTTTGCACACGTTAATGTGACATGCGTTGATCGCTAATTTTGGGGCATTGTATATTTCTTCCATATGTGGAAGCTAAATTAATGTAGATAGAAATTAGTTATTTTTTTCCCTGTAGATAGTACTAACTAAATATATATTGAAATGAGCTTGCAGTGACCTTTGTTAAAATGCTTTTAGGAAAGCATTGCTGCTATTAAAATTTCTATTTTTAGAAATGTTTTGGTTTTTTTTTTCTGGACCAAAATGCCCCACATTTAGTTGTTCAAGGCTGTAATGCCTAGTTTAAACAATTTTATTTATGTTATTTTTTTTGACATTCCAGACCATTATTGTGCATATTGTATATAATCAAGAGATGTATATTTAAACTGATATAAGTGTATGAGTTGAACATGCCAATGTACTGTAATTAATAAGATAAAGTATCTTTTTTGTGACCAAACCTGTGGGTTTGCAATAAAACTTAAAAAATTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA	Refseq >NM_001090340\|Xenopus laevis serum/glucocorticoid regulated kinase 1 (sgk1-a), mRNA TGCTCTCAAAGTGTTTGTTCCTCTTGGATTATACACGGCGCCCGATTTTCTCACACACCCAACCATGACTGTAAAGACAGAAACGGCGGCGGGTGCAAGCACACTGACTTATTCTAAGATGAGGGGAATGGTGGCTTTGCTTATCGCTTTTATGAAACAACGAAGAATGGGACTGAATGATTTCATCCAGAAAATTGCAACCAACTCTTCCTATGCCTGCAAACCCTCTGAAGTGCAGTCAATCCTGAATATCTCACCCCCCCAAGAACCAGAATTACTGAATGAAAATTCCTCGCCTCCCCCTAGCCCTTCTCAACAGATCAACCTTGGTCCTTCATCCAACCCTCATGCAAAACCATCCGACTTCCAGTTTCTGAAAATCATTGGCAAGGGTAGTTTTGGAAAAGTTCTCCTGGCAAGACACCAAGCAGATGAGAAATTCTATGCAGTGAAAGTGCTTCAGAAAAAAGCCATTCTCAAAAAGAAAGAGGAGAAACACATAATGTCAGAGCGCAATGTACTGTTAAAAAATGTGAAACACCCTTTCCTGGTTGGGCTCCACTTCTCTTTCCAGACAACTAGCAGATTGTATTTTATTCTGGACTACATCAATGGCGGAGAGTTGTTCTACCATCTCCAGAGAGAAAGATGCTTCTTGGAACCCAGAGCTCGTTTTTATGCTGCTGAAATAGCCAGTGCGCTAGGATACTTGCATTCTCTCAACATTGTTTATCGTGACTTGAAGCCAGAAAACATTTTGTTGGACTCCCAGGGCCACATTGTTCTGACAGATTTTGGTCTTTGCAAGGAGAACATAGAGCCCAATGGCACTACATCTACCTTCTGCGGCACTCCTGAGTATCTTGCTCCAGAAGTTCTACACAAACAGCCTTATGACAGGACAGTTGATTGGTGGTGCCTGGGAGCAGTGTTGTATGAGATGTTGTATGGCCTGCCTCCTTTCTACAGTAGAAATACTGCTGAAATGTATGACAATATCTTGAACAAGCCACTGCAGCTAAAACCAAACATAACCAACTCAGCCAGGAACCTCCTGGAGGGTCTTCTGCAGAAGGACCGGACAAAAAGGATTGGTGCCAAGAATGACTTTATGGAGATTAAGAACCACATCTTTTTCTCTCCAATTAACTGGGATGATCTGATTAATAAGAAGATAACACCTCCCTTCAACCCAAATGTGAGTGGCCCAAGTGACCTGCAACACTTCGATCCAGAATTCACAGAAGAGCCTGTCCCCAATTCTATTGGCCAGTCTCCGGATAGCATCCTAATAACTGCCAGCATTAAAGAAGCTGCAGAAGCATTCATGGGCTTTTCTTATGCACCACCTATGGAATCCTATCTTTGAGAGATCCTCCCTTCTTGTCTAGTAGTCATTTACAATCAAATCACTTTGATTTTTTCATTTCCTTTTGAAGAAATTTGCACATCGTTCACAACAGCATCACAGCCTTAATTTCAACATCCTGGTATTGCTGGAGTAGTGAATAAGTGGAGCTAAGAAAAGGATAGAAAAAAAAGTGACAATATCCTCTGTTGTTGGGAGAAATATGAACGATCTGCTGAATTTGCAGCACACAACCCTTATATTATCTTACAGAGGGATACATGAGGGTTTGTTAAGCTGGAAGAGGGCATCTAAGCATGTCTTATAGTATGGGGCTTTTGCAACGTGCCTTTCTCTTTTGAGAGATCTTGTCTAGTTTAAGAACCATCCACATGACCTGGAGGTTCTTTGGTTTTGACAGTGGTTTTACAAGTGAACAATGGTATGAGTGTGAAGCTTATCACAGTAAGACTGTGGTTTTGCACACGTTAATGTGACATGTGTTGATCACTAATTTTGGGGCATTGTACATTTCTTCCATATGTGGAAGCTAAATTTAATGTAGATAGAAATGTAGTTATTTTTTCCTGTAGATAGTACTAATTAAACATATTGAAATGTGCTCACAATGACCTTTGTTAAAAATGCTTTAAGAAAAGCATTGCTGCTATTGAGATTTCTATTTTTAGAAATGTTTTTGTTTTTTCTTGACCAAAATGCCCCACATTTAGTGGTTCAAGTCTGTAAAGCCTAGTTTAACAAACATTTTTATTTATGTTATATTTTTGACATTCCAGACCATTATTGTGCATATTGTATATAATCAAGAGTTGTATATTTAAACTGACAAATATAAGTGTTGAACATGTACTGTAATTAATAAGATAAAATGTATCTTTTTGTGACCAAACCTGTGGGTTTGCAATAAAACTTTAAAATACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA		Refseq >NM_001092720\|Xenopus laevis serum/glucocorticoid regulated kinase 1 (sgk1-b), mRNA CGCTTCAAAGTGTTTTTGCTTTTGGATTATTCACGACATCAGCTTTTCTCACACACTAAACCATGACTGTAAAGACAGAGACGGCTGCGGGTGCCAGCACACTAACTTACTCTAAGATGAGGGGAATGGTGGCTTTGCTTATTGCTTTTATGAAACAACGAAGAATGGGGCTGAATGAATTTATCCAGAAAATTGCAACCAACTCTTCATATTCATGCAAACCCTCTGAAGTGCAGTCAATCCTGAATATCTCACCCCCCCAAGAATCAGAATTACTGAATGAAAATTCCTCACCTCCTCCTAGCCATTCTCAACAGATCAACCTTGGTCCTTCATCCAACCCTCATGCAAAACCATCTGACTTCCAGTTTCTGAAAATCATTGGCAAGGGTAGTTTTGGAAAGGTTCTTCTGGCAAGACACAAAGCAGATGAGAAATTCTATGCAGTGAAGGTGCTTCAGAAAAAAGCAATTCTTAAAAAGAAAGAGGAGAAACACATAATGTCAGAGCGCAATGTACTGTTAAAAAATGTGAAACACCCTTTCTTGGTTGGGCTCCACTTCTCTATCCAAACAACTAGCAGACTGTATTTTATTCTGGACTACATCAATGGTGGAGAGTTGTTCTACCACCTCCAGAGAGAACGATGTTTCTTGGAACCCAGAGCTCGTTTTTATGCTGCTGAAATAGCCAGTGCACTAGGATACTTGCACTCTCTCAACATTGTTTATCGTGACTTGAAGCCAGAAAACATTTTGTTGGATTCCCAGGGCCACATTGTTCTGACTGATTTTGGCCTTTGTAAGGAGAACATAGAGCCAAATGGTATTACATCTACCTTCTGTGGTACTCCTGAGTATCTTGCACCAGAAGTTCTGCACAAACAGCCTTATGACAGGACAGTTGACTGGTGGTGTCTGGGAGCAGTGTTGTACGAGATGTTGTATGGCCTGCCTCCTTTCTACAGTAGAAACACTGCTGAAATGTATGACAATATCTTGAACAAGCCACTGCAGCTAAAACCAAACATAACCAACTCAGCCAGGAACCTCCTGGAGGGTCTTCTGCAGAAGGACCGGACAAAAAGGACTGGTGCAAAGACCGACTTTATGGAGATTAAGAACCACATATTTTTCTCTCCAATTGACTGGGATGATCTGATTAATAAGAAGATTACACCTCCCTTCAACCCAAATGTGAGTGGCCCAAGTGACCTGCAACACTTTGATCCTGAATTTACAGATGAGCCTGTCCCCAATTCTATTGGCCAGTCTCCGGACAGCATCCTTATAACTGCCAGCATTAAAGAAGCTGCAGAAGCATTCATGGGCTTTTCTTATGCTCCACCTATGGACTCATACCTTTGAGTGATCCTACCTTCTCATCTTGTAATTATTTACAATCAAGTCACTTGAATTTATATTTCCTTTTGATGAAATTTGCACATCCTACCCGACCGCATCACAGCCTTAATTTCAACATCCGTGGTATTGATGGAAGCAGCAAATCAGTGGAGCTAAGAAAAGGATAGAAAGTGACTTTGGATTTCATCTTCTGTTGGGAGAAATAAGAAATATCTGCAGAAATGGCAATATACAACCCTTATATTATCATACAGAGAGATACATGAGGGCTTGTTGAGTGTGGGACTTTTGCAACGTGCCTTTCTCTTTTGAGAGATCTTGTCTAGCTTAAGAATCATCCATATGACCTGGAGGCTCTTTGGTTTTGACAGTGGTTTTACAAGTGAACAATGGTATGAGTGTGACGCTTATCACAGTAACTGCGGTTTTGCACACGTTAATGTGACATGCATTGATCACTAACTTTGGGGCATTGTATATTTTTTCCATATGTGGAAGCTAAATTTAATGTAGATACATTTTTTTTTTTCCTATAGATTGTACTAACTAAATGTATTGTAATGCACTTACAATGACCTTTGTTAGAATGCTTTAAGAAAAGCATTGCTGCTATTGAGATTTTTATTTTAAGAAAAAAAAAATTTCTGGACCAAAATGCCCCACATTTAGTTGTTCAAGTCTGCAATGCCTCGTTTAACAAACTTTATTTATGTTATGTTTTTGACATTCCAGACCATTATTGTGCATATTGTATATAATGAAGAGTTGTATATTTAAACTGACAGATATGTCAATGTACTGTAATTAATAAGATATGTATTTTTTTTGTGACCAAACCTGTGGGTTTGCATTAAAACTTAAAAAAATAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Protein		Refseq >NP_001025593\|serine/threonine-protein kinase Sgk1 [Xenopus (Silurana) tropicalis] MRTKNEKSPLKAFMKQRRMGLNDFIQKIATNSSYACKHSEVQSILNISPPQEPELLNENSSPPPSPSQQINLGPSSNPHAKPSDFQFLKIIGKGSFGKVLLARHNADEKFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTTSRLYFILDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIILTDFGLCKENIEPNGTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARNLLEGLLQKDRTKRIGAKNDFMEIKNHMFFSPINWDDLINKKITPPFNPNVSGPSDLQHFDPEFTEEPVPNSIGQSPDSILITASIKEAAEAFMGFSYAPPMESYL UniProtKB	Refseq >NP_001083809\|serine/threonine-protein kinase Sgk1-A [Xenopus laevis] MTVKTETAAGASTLTYSKMRGMVALLIAFMKQRRMGLNDFIQKIATNSSYACKPSEVQSILNISPPQEPELLNENSSPPPSPSQQINLGPSSNPHAKPSDFQFLKIIGKGSFGKVLLARHQADEKFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTTSRLYFILDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEPNGTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARNLLEGLLQKDRTKRIGAKNDFMEIKNHIFFSPINWDDLINKKITPPFNPNVSGPSDLQHFDPEFTEEPVPNSIGQSPDSILITASIKEAAEAFMGFSYAPPMESYL UniProtKB		Refseq >NP_001086189\|serine/threonine-protein kinase Sgk1-B [Xenopus laevis] MTVKTETAAGASTLTYSKMRGMVALLIAFMKQRRMGLNEFIQKIATNSSYSCKPSEVQSILNISPPQESELLNENSSPPPSHSQQINLGPSSNPHAKPSDFQFLKIIGKGSFGKVLLARHKADEKFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSIQTTSRLYFILDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEPNGITSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARNLLEGLLQKDRTKRTGAKTDFMEIKNHIFFSPIDWDDLINKKITPPFNPNVSGPSDLQHFDPEFTDEPVPNSIGQSPDSILITASIKEAAEAFMGFSYAPPMDSYL UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase

Synteny		Metazome

Expression		tropicalis	laevis a		laevis b
UniGene		Str.46177 [+] Str.47016 Str.51027	Xl.7842		Xl.47551
Unigene EST Profile		EST Profile	EST Profile		EST Profile
GEO data			GEO		GEO
Images		11 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	SGK1
mouse		MGI	Sgk1	All(6) Targeted, knock Out(2)
zebrafish		ZFIN	sgk1	2 Lines(s)

Publications
First:		Epithelial sodium channel regulated by aldosterone-induced protein sgk. [Proc Natl Acad Sci U S A 1999]
Most recent:		WNK4 inhibits Ca(2+)-activated big-conductance potassium channels (BK) via mitogen-activated protein kinase-dependent pathway. [Biochim Biophys Acta 2013]
		View All Papers

Functional Ontologies
GO: Molecular:		ATP binding cAMP-dependent protein kinase activity cAMP-dependent protein kinase regulator activity More[+] protein kinase CK2 activity protein kinase CK2 regulator activity protein kinase activity protein serine/threonine kinase activity protein tyrosine kinase activity
Biological:		protein amino acid phosphorylation
Cellular Component:		cAMP-dependent protein kinase complex protein kinase CK2 complex
EC:		now divided into EC:2.7.11.1, EC:2.7.11.8, EC:2.7.11.9, EC:2.7.11.10, EC:2.7.11.11, EC:2.7.11.12, EC:2.7.11.13, EC:2.7.11.21, EC:2.7.11.22, EC:2.7.11.24, EC:2.7.11.25, EC:2.7.11.30 and EC:2.7.12.1
KOG:		[RT] Ribosomal protein S6 kinase and related proteins

Reagents		tropicalis	laevis a		laevis b
Clones		open biosystems	open biosystems		open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes		geneservice/RZPD imagenes
Affymetrix 1.0		Str.10900.1.S1_at [+] Str.47016.1.A1_at	Xl.7842.1.S1_at
Affymetrix 2.0			Xl2.7842.1.S1_at		Xl2.47551.1.S1_at

Symbol legend[+]