Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (13) GO Terms (18) Nucleotides (245) Proteins (35) Interactants (212) Wiki
XB-GENEPAGE-1006796
Gene Symbol:
cyp17a1

Gene Name:
cytochrome P450 family 17 subfamily A member 1

Synonyms:
P450 CYP17 ( Add synonyms , Nomenclature history )

Gene Function:
Cytochrome P450 CYP2 subfamily

Protein Function :
Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and ...[+]



Interactants:
Loading ...

Diseases: 


Disease Ontology:
congenital adrenal hyperplasia

OMIM:
ADRENAL HYPERPLASIA, CONGENITAL, DUE TO 17-ALPHA-HYDROXYLASE DEFICIENCY

External Links:
 
Xenbase Gene ID XB-GENE-1006797 XB-GENE-1006800 XB-GENE-17339972
Gene Symbol cyp17a1 cyp17a1.L cyp17a1.S
Chromosome Chr7 Scaffold61
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1
CDS Gene model Gene model
Entrez Gene 100145650
100036774
mRNA NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein RefSeq  More.. NCBI Protein RefSeq  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine cyp17a1 cyp17a1.L cyp17a1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards CYP17A1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Cyp17a1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Cyp17a1 Ensembl
zebrafish
ZFIN, AGR cyp17a1 ZFIN Ensembl
chicken
GEISHA CYP17A1 Ensembl
fruit fly
worm
Publications
First Xenopus laevis ovarian CYP17 is a highly potent enzyme expressed exclusively in oocytes. Evidence that oocytes play a critical role in Xenopus ovarian androgen production., J Biol Chem 2003    
Most Recent Pesticide-induced multigenerational effects on amphibian reproduction and metabolism., Sci Total Environ 2021                        
All View All Papers 1 paper(s) referencing morpholinos
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 18 terms 7 terms 0 term
PANTHER cyp17a1
KEGG Pathways K00512 K00512
KOG [Q] Cytochrome P450 CYP2 subfamily
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks cyp17a1
ORFs cyp17a1.L ORF1
Clones Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info