tcf4 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Summary

Gene Literature (36)

Nucleotides (76)

Interactants (127)

XB-GENEPAGE-1011627

Gene Symbol: tcf4 Gene Name: transcription factor 4 Synonyms: tcf-4, Xtcf-4, Xtcf4 Add Xenopus synonyms Gene Function: helix-loop-helix (bHLH) transcription factor Interactants: tcf7l2(22) , lef1(14) , tcf3(14) , tle4(10) , tcf7(9) , tcf7l1(9) , sia1(8) View All	1/3

XB-GENE-1011628

XB-GENE-1011632

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_001102756\|Xenopus (Silurana) tropicalis transcription factor 4 (tcf4), mRNA GAAATCTGGTTTGAGTTTCCCTTTGCCTGGAATGTGAGTCAGTTTAAAGCAGGTGGCAGCGTGCGGTTGTTTTGGGGGCATTCATTCATTAATGAGATGGATATTGCGGCAGCTTGGATGGCAAAGATGTTTTCCCCTCCTGTGAGCAGTGGCAAGAATGGACCAACTTCCCTGGCAAGTGGACATTTTTCAGGAACAAATGTAGAAGACAGAAGTAACTCAGGGTCCTGGGGGAACAGTGCACATCCAAGTCCATCTAGAAAGCTGTCATGCAGTGTGCAAGCCAGCGTGCATAGCCATCCACCCCGGAGGTGGCTGCATAGTTACGGGGAAGGAGGCCATTTTGAACACATGACCAGCAGGGATCTGAGCTCGCACTCACATGACAATCTCTCGCCGCCGTTTGTCAACACAAGAATACAAGGCAAATCAGATAGAAATTCATATTCCTGTTATGGGAGGGATTCAGAGATGCAGGGCTGCCATCAGCAAAGCCTCCTTGGAGGGGACATGGAAATGGCAAACACAGGAGCACTTTCGCCTACGAAACCCGGATCCCAATACTATCCGTACTCAAGCAATAACCCCCGGAGGAGGCCTTTTCACGGCAGTTCAATGGAAGTGCAAGCGAAGAAGGTCAGGAAGGTTCCACCTGGACTACCCTCTTCGGTTTATGCCCCATCAGCAAGCACTGCCGACTACAATAGGGACTCGCCAGGTTATCCATCCTCAAAGCCAGCCGCCAGCACTTTTCCCAGTTCCTTCTTCATGCAAGATGGCCACCATAGCAGTGACCCATGGAGTTCATCCAGTGGAATGAACCAAGCTGGGTATGGAGGGATGCTTGGCAACTCTTCTCATATTCCACAGTCAAGCAGCTACTGTAACCTGCATCCACATGAACGACTGAGCTATCCATCACACTCCTCCACAGACATCAATTCCAGCCTTCCTCCAATGTCTACATTTCATCGCAGTGGTACAAATCATTACAGTACCTCGTCCTGCACGCCACCGGCCAATGGAACAGAAAGCATCATGACAAACAGAGGGAGCGCGGCAACCGGGAGCTCGCAGACCGGCGATGCGCTGGGGAAAGCACTTGCCTCTATTTATTCTCCAGATCACACCAACAACAGTTTCTCATCAAACCCATCAACTCCAGTTGGGTCTCCACCTTCTCTATCAGCAAGCACAGCTGTTTGGTCAAGGAACGGAGGACAGACTTCCTCATCTCCAAACTACGAGGGCCCATTGCACACTCTACAAAGTCGAATTGAGGACAGATTGGAAAGACTAGATGATGCAATTCACGTCTTACGGAACCACGCAGTGGGGCCTTCAACAGCCATGCCAGGAAGCCACAGCGAGTTACATGGGCTAATAGGTCCTTCTCACAATGGGGCGATGGGTGGCATTGGATCAGGATATGGAACGGGTCTCCTCTCGGCAAACAGGCATTCCCTGATGGTTGGAGCTCATCGTGAAGATGGTGTTAATCTACGGGGCAGTCACTCCCTCGTGCCAAATCAGGTGTCCGTCCCACAGTTACCTGTACAGTCGGCTACGTCACCCGATTTGAACTCCGACCAAGACCCATACCGGGGTATCCCAACCGGTCTCCAAGCACAGGCCGTCTCTCCAGGCAGTTCCGAGATCAAATCCGAAGACGAAGGGGACGAAAACCTTCACGACTCGAAATCTTCCGACGACAAGAAATTAGATGACGACAAGAAGGATGTCAAATCAATTACAAGCAATAATGATGATGAAGACCTGACCCCAGAGCAGAAGGCAGAGAGAGAGAAGGAAAGGCGGATGGCAAACAATGCGCGAGAGCGCCTCCGCGTCCGTGATATTAATGAGGCTTTCAAGGAGCTGGGCCGCATGGTGCAACTTCACCTGAAGAGCGATAAGCCCCAAACCAAGCTCTTAATACTGCACCAGGCCGTGGCAGTCATACTGAGCTTAGAGCAGCAAGTCCGCGAGAGAAATCTGAACCCTAAAGCTGCCTGCCTAAAGCGAAGAGAAGAAGAAAAGGTTTCCTCCGACCCCTCGCCTCTGTCCCTGGCAGGCCCTCACCCTGGGATGGGAGATGCAGCAAATCATTTGGGGCAGATGTAAAAAGGTCCAAGGTTTTTTTCATTTTTTCATTTTTTTTTTTTTTTTTTTTTTTTTGCGTTTCTTCGTTTAGACAAGAAGCCACTTCCTTAACAGCTGTATTATCTTAAACCCACACAAACACTTCTCCTGTATCCCTTTTTTCTTTTTGTAAGATATGAGACAAGTCTGAGTAGTTATATGCACCGCAGACGCAAGAGGTTTCAGCATTCCCGATGCAAGAAAAAAAAAAACGGAAAAAAAGTGCAACTTGAGAACTTTTCAGTGTTACCGTATAGCGAATGTTCCAAGCATTGCGTCGCAGCCTCGTGACTGGCAATCTTCTCCACACTGTGGAACCATGCATTTGTGCCTAAACTTCTTTTGGAATAAAGAAAAAAAAAATAAAAAAAAAAAAAAAAAAAAAAAA	NCBI Nucleotide >U25961\|Xenopus laevis helix-loop-helix transcription factor XE2 mRNA, partial cds AAGAAATTAGACGACGACAAGAAGGATATCAAATCAATTACAAGCAATAATGATGACGAAGACCTGACCCCAGAGCAGAAGGCAGAAAGAGAGAAGGAAAGGCGGATGGCAAACAATGCCCGAGAGCGTCTCCGCGTCCGTGATATTAATGAGGCTTTTAAGGAGCTGGGCCGCATGGTGCAAATTCATCTGAAGAGCGATAAGCCACAAACCAAGCTCTTAATACTGCATCAGGCTGTGGCCGTCATACTCAACTTAGAGCAGCAAGTCCGAGTTCGCATTTTGTTTGCAGAGAGAAATTTGAACCCTAAAGCTGCCTGCCTAAAGCGAAGAGAAGAAGAAAAGGTTTCCTCCGATCCCTCACCACTGTCCCTGGCAGGTCGG
Protein		Refseq >NP_001096226\|transcription factor 4 [Xenopus (Silurana) tropicalis] MDIAAAWMAKMFSPPVSSGKNGPTSLASGHFSGTNVEDRSNSGSWGNSAHPSPSRKLSCSVQASVHSHPPRRWLHSYGEGGHFEHMTSRDLSSHSHDNLSPPFVNTRIQGKSDRNSYSCYGRDSEMQGCHQQSLLGGDMEMANTGALSPTKPGSQYYPYSSNNPRRRPFHGSSMEVQAKKVRKVPPGLPSSVYAPSASTADYNRDSPGYPSSKPAASTFPSSFFMQDGHHSSDPWSSSSGMNQAGYGGMLGNSSHIPQSSSYCNLHPHERLSYPSHSSTDINSSLPPMSTFHRSGTNHYSTSSCTPPANGTESIMTNRGSAATGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSASTAVWSRNGGQTSSSPNYEGPLHTLQSRIEDRLERLDDAIHVLRNHAVGPSTAMPGSHSELHGLIGPSHNGAMGGIGSGYGTGLLSANRHSLMVGAHREDGVNLRGSHSLVPNQVSVPQLPVQSATSPDLNSDQDPYRGIPTGLQAQAVSPGSSEIKSEDEGDENLHDSKSSDDKKLDDDKKDVKSITSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSDPSPLSLAGPHPGMGDAANHLGQM	NCBI Protein >AAA92049\|XE2 [Xenopus laevis] KKLDDDKKDIKSITSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQIHLKSDKPQTKLLILHQAVAVILNLEQQVRVRILFAERNLNPKAACLKRREEEKVSSDPSPLSLAGR

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase

Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.53448	Xl.58751
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		14 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	TCF4	OMIM:610954
mouse		MGI	Tcf4	All(5) Targeted, knock Out(4) Targeted, other(5)
zebrafish			tcf4

Publications
First:		TCF-4 binds beta-catenin and is expressed in distinct regions of the embryonic brain and limbs. [Mech Dev 1998]
Most recent:		Subfunctionalization and neofunctionalization of vertebrate Lef/Tcf transcription factors. [Dev Biol 2012]
		View All Papers 6 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:
Biological:
Cellular Component:
EC:
KOG:		[K] Helix loop helix transcription factor

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.4135.2.S1_a_at [+] Str.4135.1.S1_at	Xl.21458.1.A1_x_at [+] Xl.21458.1.S1_at Xl.21458.1.A1_at Xl.21458.1.S1_x_at Xl.21458.2.S1_x_at Xl.21458.2.A1_x_at
Affymetrix 2.0			Xl2.34768.1.S1_at [+] Xl2.34768.2.A1_at Xl2.34768.2.S1_x_at

Symbol legend[+]