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Summary Expression Gene Literature (6) GO Terms (12) Nucleotides (149) Proteins (20) Interactants (233) Wiki
XB-GENEPAGE- 1016131

Gene Symbol: dlg1

Gene Name: discs, large homolog 1

Synonyms: dlgh1 , sap97 , sap-97
Add Xenopus synonyms , Nomenclature history


Gene Function: Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains)

Protein Function:
Essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role i...[+]


Interactants: YYY

OMIM Disease Associations:
 
Xenbase Gene ID XB-GENE-1016132 XB-GENE-6487124 XB-GENE-17344164
Gene Symbol dlg1 dlg1.L dlg1.S
Chromosome scaffold_2 Scaffold142433
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 6.0
Entrez Gene
mRNA Refseq
Protein Refseq Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
GBrowse
tropicalis genome v7.1 gene model
GBrowse
laevis genome v6.0 gene model
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.51799 Xl.34623 [+]
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Images 5 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine dlg1 dlg1.L dlg1.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen tegg018e06      
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards DLG1 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Dlg1 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN dlg1 ZFIN Ensembl
chicken
GEISHA DLG1 Ensembl
fruit fly
FLYBASE dlg1 Ensembl
worm
WORMBASE
Publications
First: Anchoring proteins confer G protein sensitivity to an inward-rectifier K(+) channel through the GK domain. [EMBO J 2000]
Most recent: KCNA4 deficiency leads to a syndrome of abnormal striatum, congenital cataract and intellectual disability. [J Med Genet 2016]
View All Papers 1 paper(s) referencing morpholinos
Functional Ontologies tropicalis laevis.L laevis.S
GO 12 terms 0 term 0 term
EC
PANTHER dlg1
KEGG Pathways K12076
KOG [F] Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains)
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience
Morpholino dlg1 MO1 dlg1 MO1 dlg1 MO1
Affymetrix 1.0 Str.25739.1.S1_at Xl.7368.2.S1_a_at [+]
Affymetrix 2.0 Xl2.34623.1.A1_at [+]

Symbol legend[+]

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