Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (91) GO Terms (35) Nucleotides (374) Proteins (35) Interactants (479) Wiki
XB-GENEPAGE- 1019625

Gene Symbol: aurkb

Gene Name: aurora kinase B

Synonyms: aik2 , aurora B , aim1 , ark2 , AurB , ipl1 , stk5 , stk12 , airk2 , aurkb-a , aurkb-b
Add Xenopus synonyms , Nomenclature history


Gene Function: serine/threonine kinase

Protein Function:
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ens...[+]


Interactants: Loading ...

OMIM Disease Associations:
 
Xenbase Gene ID XB-GENE-1019626 XB-GENE-1019634 XB-GENE-6256242
Gene Symbol aurkb aurkb.L aurkb.S
Chromosome scaffold_100 chr3L Scaffold20
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq Refseq Refseq
Protein Refseq Swiss-Prot Refseq Swiss-Prot TrEMBL Refseq Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.45796 [+] Xl.6652 Xl.4033
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 4 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine aurkb aurkb.L aurkb.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen tegg085p18      
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards AURKB OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Aurkb MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN aurkb ZFIN Ensembl
chicken
GEISHA AURKA Ensembl
fruit fly
worm
WORMBASE
Publications
First: Phosphorylation by a G protein-coupled kinase inhibits signaling and promotes internalization of the monocyte chemoattractant protein-1 receptor. Critical role of carboxyl-tail serines/threonines in receptor function. [J Immunol 1996]
Most recent: Chromosomal passenger complex hydrodynamics suggests chaperoning of the inactive state by nucleoplasmin/nucleophosmin. [Mol Biol Cell 2017]
View All Papers 3 paper(s) referencing morpholinos
Functional Ontologies tropicalis laevis.L laevis.S
GO 33 terms 28 terms 26 terms
EC now divided into EC:2.7.11.1, EC:2.7.11.8, EC:2.7.11.9, EC:2.7.11.10, EC:2.7.11.11, EC:2.7.11.12, EC:2.7.11.13, EC:2.7.11.21, EC:2.7.11.22, EC:2.7.11.24, EC:2.7.11.25, EC:2.7.11.30 and EC:2.7.12.1
PANTHER aurkb
KEGG Pathways K11479 K11479 K11479
KOG [D] Serine/threonine protein kinase
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience Source BioScience
Antibody Aurkb Ab1 , Aurkb Ab2 , aurka/b Ab1 Aurkb Ab1 , Aurkb Ab2 , aurka/b Ab1 Aurkb Ab1 , Aurkb Ab2 , aurka/b Ab1
Morpholino aurkb MO1 aurkb MO1 aurkb MO1
ORF aurkb ORF1 aurkb ORF2
Affymetrix 1.0 Str.8758.1.S1_a_at [+] Xl.6652.1.S2_at Xl.4033.1.A1_at
Affymetrix 2.0 Xl2.6652.1.S2_at Xl2.4033.1.S1_at

Symbol legend[+]

My Xenbase: [ Log-in / Register ]
version: [4.6.0]

Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556