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XB-GENEPAGE-
1031984
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Gene Symbol: tcf7l1
Gene Name: transcription factor 7 like 1 Synonyms: tcf3c , tcf3d , XTCF-3 , xtcf3 , tcf7l1-a , tcf7l1-b Add Xenopus synonyms , Nomenclature history Gene Function: high mobility group transcription factor Protein Function  :
Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of ctnnb1-A and possibly ctnnb1-B, and as an activator in the presence of these proteins. Required early i...[+]
Interactants: Loading ... 
Disease Ontology: OMIM Diseases: |
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| Xenbase Gene ID | XB-GENE-1031985 | XB-GENE-6252329 | XB-GENE-1031992 | ||||||||||
| Gene Symbol | tcf7l1 | tcf7l1.L | tcf7l1.S | ||||||||||
| Chromosome | Chr03 | chr3L | chr3S | ||||||||||
| Molecules | tropicalis | laevis.L | laevis.S | ||||||||||
| Gene |
Genomic sequence
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Genomic sequence
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Genomic sequence
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| CDS |
Gene model
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Entrez Gene
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Entrez Gene
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Entrez Gene
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| mRNA |
Refseq
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Refseq
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Refseq
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| Protein
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Refseq
Swiss-Prot
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Refseq
Swiss-Prot
TrEMBL
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Refseq
Swiss-Prot
TrEMBL
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| Genomic | tropicalis | laevis.L | laevis.S | ||||||||||
| Genome Browser |
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| Genomic Synteny | Genomicus | ||||||||||||
| Expression | tropicalis | laevis.L | laevis.S | ||||||||||
| Ensembl | Ensembl | ||||||||||||
| UniGene | Str.11534 [+] | Xl.1100 | Xl.85456 [+] | ||||||||||
| RNA-Seq profile | Stage profile: |
Stage profile:
Tissue heatmap:
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| Experimental regulation |
Regulation heatmap:
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| Images | 4 expression image(s) for tropicalis and laevis | ||||||||||||
| Data Mining | tropicalis | laevis.L | laevis.S | ||||||||||
| XenMine | tcf7l1 | tcf7l1.L | tcf7l1.S | ||||||||||
| Phenotype | tropicalis | laevis.L | laevis.S | ||||||||||
| Smith Morpholino Screen | |||||||||||||
| Orthology |
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| worm |
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| Publications | |||||||||||||
| First: |
XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos. [Cell 1996]
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| Most recent: | Tcf7l1 promotes transcription of Kruppel-likefactor 4 during Xenopus embryogenesis. [J Biomed Res 2017] | ||||||||||||
| View All Papers 23 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 2 paper(s) referencing Disease Ontology | |||||||||||||
| Functional Ontologies | tropicalis | laevis.L | laevis.S | ||||||||||
| GO | 11 terms | 13 terms | 8 terms | ||||||||||
| PANTHER | tcf7l1 | ||||||||||||
| KEGG Pathways | K04490 | K04490 | K04490 | ||||||||||
| KOG |
[K] Transcription factor TCF-4
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| Reagents | tropicalis | laevis.L | laevis.S | ||||||||||
| CRISPR / TALEN | CRISPR tools | CRISPR tools | CRISPR tools | ||||||||||
| Clones | |||||||||||||
| GE Dharmacon | GE Dharmacon | GE Dharmacon | |||||||||||
| Source BioScience | Source BioScience | Source BioScience | |||||||||||
| Morpholino | tcf7l1 MO1 , tcf7l1 MO2 , tcf7l1 MO3 , tcf7l1 MO4 | tcf7l1 MO1 , tcf7l1 MO2 , tcf7l1 MO3 , tcf7l1 MO4 | tcf7l1 MO1 , tcf7l1 MO2 , tcf7l1 MO3 , tcf7l1 MO4 | ||||||||||
| ORF | tcf7l1.S ORF1 | ||||||||||||
| Affymetrix 1.0 | Str.24440.1.S2_at [+] | Xl.46.1.S1_at [+] | |||||||||||
| Affymetrix 2.0 | Xl2.46.2.S1_a_at [+] | ||||||||||||
Symbol legend[+]
