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Summary Expression Gene Literature (483) GO Terms (20) Nucleotides (318) Proteins (46) Interactants (764) Wiki
XB-GENEPAGE-1031984
Gene Symbol:
tcf7l1

Gene Name:
transcription factor 7 like 1

Synonyms:
tcf3c , tcf3d , XTCF-3 , xtcf3 , tcf7l1-a , tcf7l1-b ( Add synonyms , Nomenclature history )

Gene Function:
high mobility group transcription factor

Protein Function :
Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of ctnnb1-A and possibly ctnnb1-B, and as an activator in the presence of these proteins. Required early i...[+]


InterPro :
RanGAP1 C sf , Leu-rich rpt , LRR dom sf , ARM-type fold [+]

Interactants:
Loading ...

Diseases: 


External Links:
 
Xenbase Gene ID XB-GENE-1031985 XB-GENE-6252329 XB-GENE-1031992
Gene Symbol tcf7l1 tcf7l1.L tcf7l1.S
Chromosome Chr3 chr3L chr3S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.2 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 448107
397863
394281
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine tcf7l1 tcf7l1.L tcf7l1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards TCF7L1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Tcf7l1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Tcf7l1 Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR tcf7l1b tcf7l1a ZFIN Ensembl
chicken
GEISHA TCF7L1 Ensembl
fruit fly
worm
Publications
First XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos., Cell 1996              
Most Recent Integration of Wnt and FGF signaling in the Xenopus gastrula at TCF and Ets binding sites shows the importance of short-range repression by TCF in patterning the marginal zone., Development 2019                            
All View All Papers 23 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 3 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 17 terms 12 terms 7 terms
PANTHER tcf7l1
KEGG Pathways K04490 K04490 K04490
KOG [K] Transcription factor TCF-4
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks tcf7l1
Morpholinos tcf7l1 MO1 , tcf7l1 MO2 , tcf7l1 MO3 , tcf7l1 MO4 tcf7l1 MO1 , tcf7l1 MO2 , tcf7l1 MO3 , tcf7l1 MO4 tcf7l1 MO1 , tcf7l1 MO2 , tcf7l1 MO3 , tcf7l1 MO4
ORFs tcf7l1.S ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

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