Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (90) GO Terms (15) Nucleotides (297) Proteins (34) Interactants (757) Wiki
Gene Symbol: tcf7l1

Gene Name: transcription factor 7 like 1

Synonyms: tcf3c , tcf3d , XTCF-3 , xtcf3 , tcf7l1-a , tcf7l1-b ( Add synonyms , Nomenclature history )

Gene Function: high mobility group transcription factor

Protein Function :
Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of ctnnb1-A and possibly ctnnb1-B, and as an activator in the presence of these proteins. Required early i...[+]

Interactants: Loading ...
Xenbase Gene ID XB-GENE-1031985 XB-GENE-6252329 XB-GENE-1031992
Gene Symbol tcf7l1 tcf7l1.L tcf7l1.S
Chromosome Chr03 chr3L chr3S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene: 448107
Entrez Gene: 397863
Entrez Gene: 394281
mRNA RefSeq RefSeq RefSeq
Protein RefSeq Swiss-Prot RefSeq TrEMBL Swiss-Prot RefSeq TrEMBL Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine tcf7l1 tcf7l1.L tcf7l1.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
MOD Entrez Gene Genetic Phenotypes Gene Expression
OMIM:Gene, HGNC, GeneCards TCF7L1 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
MGI, AGR Tcf7l1 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
ZFIN, AGR ZFIN, AGR tcf7l1b tcf7l1a ZFIN Ensembl
fruit fly
First XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos., Cell 1996              
Most Recent Barhl2 maintains T cell factors as repressors and thereby switches off the Wnt/β-Catenin response driving Spemann organizer formation., Development 2019                                              
All View All Papers 23 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 3 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 12 terms 12 terms 7 terms
PANTHER tcf7l1
KEGG Pathways K04490 K04490 K04490
KOG [K] Transcription factor TCF-4
Reagents tropicalis laevis.L laevis.S
Dharmacon Dharmacon
Morpholino tcf7l1 MO1 , tcf7l1 MO2 , tcf7l1 MO3 , tcf7l1 MO4 tcf7l1 MO1 , tcf7l1 MO2 , tcf7l1 MO3 , tcf7l1 MO4 tcf7l1 MO1 , tcf7l1 MO2 , tcf7l1 MO3 , tcf7l1 MO4
ORF tcf7l1.S ORF1
Affymetrix 1.0 Str.24440.1.S2_at [+] Xl.46.1.S1_at [+]
Affymetrix 2.0 Xl2.46.2.S1_a_at [+]

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.12.1

Major funding for Xenbase is provided by grant P41 HD064556