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Summary Expression Gene Literature (53) GO Terms (12) Nucleotides (57) Proteins (30) Interactants (542) Wiki
XB-GENEPAGE-1032966
Gene Symbol:
ascl1

Gene Name:
achaete-scute family bHLH transcription factor 1

Synonyms:
ash1 , Xash1 , Mash1 ( Add synonyms , Nomenclature history )

Gene Function:
HAND2 type transcription factor

Protein Function :
Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. D...[+]


Interactants:
Loading ...

Diseases: 


Disease Ontology:
congenital central hypoventilation syndrome

OMIM:
CENTRAL HYPOVENTILATION SYNDROME, CONGENITAL; CCHS

External Links:
GEO Series :
GSE76915.
1/2
 
Xenbase Gene ID XB-GENE-1032967 XB-GENE-1032969 XB-GENE-17340658
Gene Symbol ascl1 ascl1.L ascl1.S
Chromosome Chr3 chr3L chr3S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.2 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100490701
378517
444423
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein RefSeq Swiss-Prot  More.. NCBI Protein RefSeq  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine ascl1 ascl1.L ascl1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC, AGR, Monarch, OMIM, GeneCards ASCL1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Ascl1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Ascl1 Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR ascl1b ascl1a ZFIN Ensembl
chicken
GEISHA ASCL1 Ensembl
fruit fly
Publications
First XASH1, a Xenopus homolog of achaete-scute: a proneural gene in anterior regions of the vertebrate CNS., Mech Dev 1993  
Most Recent Cellular response to spinal cord injury in regenerative and non-regenerative stages in Xenopus laevis., Neural Dev 2021                                
All View All Papers 6 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 1 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 0 term 12 terms 4 terms
PANTHER ascl1
KEGG Pathways K09067 K09067
KOG [K] Transcription factor HAND2/Transcription factor TAL1/TAL2/LYL1
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks ascl1
Mutants Xtr.ascl1emHorb
Morpholinos ascl1 MO1 ascl1 MO2
ORFs ascl1.S ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info