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Summary Expression Gene Literature (39) GO Terms (15) Nucleotides (42) Proteins (17) Interactants (337) Wiki
XB-GENEPAGE- 1032966

Gene Symbol: ascl1

Gene Name: achaete-scute family bHLH transcription factor 1

Synonyms: ash1 , Xash1 , Mash1
Add Xenopus synonyms , Nomenclature history


Gene Function: HAND2 type transcription factor

Protein Function:
Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. D...[+]


Interactants: Loading ...

OMIM Disease Associations: CENTRAL HYPOVENTILATION SYNDROME, CONGENITAL; CCHS
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Xenbase Gene ID XB-GENE-1032967 XB-GENE-1032969 XB-GENE-17340658
Gene Symbol ascl1 ascl1.L ascl1.S
Chromosome Chr03 chr3L chr3S
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 8.0 JBrowse 8.0 GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0 GBrowse 9.1 JBrowse 9.1
Entrez Gene
Entrez Gene
Entrez Gene
mRNA NCBI Nucleotide Refseq Refseq
Protein NCBI Protein Refseq Swiss-Prot TrEMBL Refseq TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.44710 Xl.450
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 11 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine ascl1 ascl1.L ascl1.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards ASCL1 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Ascl1 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN ZFIN ascl1b ascl1a ZFIN Ensembl
chicken
GEISHA ASCL1 Ensembl
fruit fly
worm
WORMBASE
Publications
First: XASH1, a Xenopus homolog of achaete-scute: a proneural gene in anterior regions of the vertebrate CNS. [Mech Dev 1993]
Most recent: Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors. [Nat Cell Biol 2016]
View All Papers 6 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs
Functional Ontologies tropicalis laevis.L laevis.S
GO 0 term 15 terms 2 terms
EC
PANTHER ascl1
KEGG Pathways K09067 K09067
KOG [K] Transcription factor HAND2/Transcription factor TAL1/TAL2/LYL1
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones   EXRC - 1 clone(s)  
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience
Morpholino ascl1 MO1 , ascl1 MO2 ascl1 MO1 , ascl1 MO2 ascl1 MO1 , ascl1 MO2
ORF MGC83023 ORF1
Affymetrix 1.0 Str.23679.1.A1_at [+] Xl.450.1.S1_at
Affymetrix 2.0 Xl2.450.1.S1_at Xl2.47609.1.S1_s_at [+]

Symbol legend[+]

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