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Summary Expression Gene Literature (52) GO Terms (36) Nucleotides (90) Proteins (29) Interactants (263) Wiki
XB-GENEPAGE-1033685
Gene Symbol:
ccdc88c

Gene Name:
coiled-coil domain containing 88C

Synonyms:
daple , XDal ( Add synonyms , Nomenclature history )

Gene Function:
myosin ATPase

Protein Function :
Positive regulator of Wnt signaling, acting synergistically with dvl2/dsh (PubMed:16026968). Functions upstream of ctnnb1/beta-catenin in the canonical Wnt pathway, and also activates jnk in the Wnt/pl...[+]



Interactants:
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Diseases: 


Disease Ontology:
spinocerebellar ataxia type 40 [+]

OMIM:
HYDROCEPHALUS, CONGENITAL, 1; HYC1 [+]

External Links:
1/3
 
Xenbase Gene ID XB-GENE-1033686 XB-GENE-17340943 XB-GENE-6487050
Gene Symbol ccdc88c ccdc88c.L ccdc88c.S
Chromosome Chr8 chr8L chr8S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model
Entrez Gene 100485260
mRNA NCBI Nucleotide
Protein NCBI Protein NCBI Protein  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine ccdc88c ccdc88c.L ccdc88c.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards CCDC88C OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Ccdc88c MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Ccdc88c Ensembl
zebrafish
ZFIN, AGR ccdc88c ZFIN Ensembl
chicken
GEISHA CCDC88B Ensembl
fruit fly
worm
Publications
First Identification and characterization of a novel Dvl-binding protein that suppresses Wnt signalling pathway., Genes Cells 2003  
Most Recent DAPLE and MPDZ bind to each other and cooperate to promote apical cell constriction., Mol Biol Cell 2019          
All View All Papers
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 21 terms 0 term 17 terms
PANTHER ccdc88c
KEGG Pathways
KOG [S] Uncharacterized coiled-coil protein
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks ccdc88c
Morpholinos ccdc88c MO1 ccdc88c MO1 ccdc88c MO1
Clones Horizon Source BioScience
Plasmids Addgene Addgene

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