Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (9) GO Terms (12) Nucleotides (162) Proteins (38) Interactants (195) Wiki
XB-GENEPAGE-1216164
Gene Symbol:
trim33

Gene Name:
tripartite motif containing 33

Synonyms:
ptc7 , rfg7 , tf1g , tif1g , tifgamma , tif1gamma , ectodermin , tif1-gamma ( Add synonyms , Nomenclature history )

Gene Function:
ubiquitin-protein ligase

Protein Function :
Acts as an E3 ubiquitin-protein ligase for smad4. Promotes ectoderm embryonic development at the expense of other germ layers. Inhibits mesodermal differentiation. Promotes neural development of the ec...[+]



Interactants:
Loading ...

Diseases: 


Disease Ontology:
thyroid gland papillary carcinoma

OMIM:
THYROID CANCER, NONMEDULLARY, 1; NMTC1

External Links:
 
Xenbase Gene ID XB-GENE-1216165 XB-GENE-1216172 XB-GENE-17339248
Gene Symbol trim33 trim33.L trim33.S
Chromosome Chr02 chr2L chr2S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 733764
733198
734959
mRNA RefSeq RefSeq RefSeq
Protein RefSeq Swiss-Prot RefSeq
Genomic
tropicalis laevis.L laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine trim33 trim33.L trim33.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards TRIM33 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Trim33 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Trim33 Ensembl
zebrafish
ZFIN, AGR trim33 ZFIN Ensembl
chicken
GEISHA TRIM33 Ensembl
fruit fly
worm
Publications
First Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase., Cell 2005                                    
Most Recent Repression of Inappropriate Gene Expression in the Vertebrate Embryonic Ectoderm., Genes (Basel) 2019          
All View All Papers 3 paper(s) referencing morpholinos 1 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 8 terms 5 terms 2 terms
PANTHER trim33
KEGG Pathways K08883 K08883 K08883
KOG [O] Predicted E3 ubiquitin ligase (alt_id KOG:2177)
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks trim33
Morpholinos trim33 MO1 trim33 MO1 trim33 MO1
ORFs trim33 ORF1 trim33.S ORF1
Clones EXRC Horizon Source BioScience Horizon Source BioScience Horizon

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
Xenbase: The Xenopus Model Organism Knowledgebase.
Version: 4.14.0
Major funding for Xenbase is provided by grant P41 HD064556