mapk8 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Summary

Gene Literature (92)

Nucleotides (151)

Interactants (265)

XB-GENEPAGE-1217555

Gene Symbol: mapk8 [provisional] Gene Name: mitogen-activated protein kinase 8 [provisional] Synonyms: jnk, jnk1, sapk1 Add Xenopus synonyms Gene Function: serine-threonine protein kinase Interactants: jun(44) , mapk1(32) , dvl2(22) , mapk14(17) , wnt11b(11) , wnt5a(11) , cdkn1a(10) View All

XB-GENE-1217556

XB-GENE-1217560

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_001129943\|Xenopus (Silurana) tropicalis mitogen-activated protein kinase 8 (mapk8), mRNA GCGGGCTGTGTTAAGAAACTCGGGGCTCTCCTGGGAAAAGCGGGGCTGTTAGGTGAGTTTCTGATCTAGAGAAGCTTGGTTTGGATGAAGCCACTGGGGTAAATGCTCGTGTAATCATGAGCCGAAGCAAGCGTGACAGCAACTTCTCTGTCTTTGAGATAGGAGATTCCACTTTTACTGTTCTCAAGCGATACCAAAATCTGAAGCCTATTGGATCTGGAGCACAGGGAATAGTATGTGCTGCCTATGATGCAGTTCTGGAGAGACATGTTGCCATCAAAAAACTGAGCCGGCCATTCCAGAATCAAACCCATGCCAAGAGAGCTTATCGAGAACTTGTGCTTATGAAATGTGTCAACCACAAGAATATAATTGGACTTCTGAATGTCTTTACTCCCCAGAAGTCATTAGAAGAGTTTCAGGACCTGTACATTGTTATGGAGCTTATGGATGCCAACCTGTGCCAGGTGATACAGATGGAATTGGACCATGAACGCATGTCCTACCTGCTATACCAGATGTTGTGTGGCATCAAACACCTACATTCTGCTGGGATCATCCACAGGGATCTAAAGCCAAGTAACATCGTAGTTAAATCGGACTGCACGCTTAAGATTCTTGATTTTGGGCTTGCACGGACAGCAGGAACCAGTTTTATGATGACACCCTATGTTGTGACTCGTTACTATAGAGCTCCAGAAGTCATCCTGGGCATGGGATATAAAGAAAATGTTGACATTTGGTCAGTGGGTTGCATCTTGGGAGAGATGATCAAAGGTGGTGTGTTATTCCCCGGCACAGACCATATCGACCAGTGGAATAAAGTAATTGAACAGTTGGGGACACCATGTCCAGAGTTTATGAAAAAATTACAGCCAACTGTGAGGACATATGTAGAAAATAGACCCAAATACGCTGGGTACAGCTTTGAGAAACTCTTTCCTGATGTTTTATTCCCTGCAGACTCTGAGCACAACAAATTGAAAGCAAGCCAAGCCAGAGATCTGCTGTCAAAAATGCTAGTAATAGATGCATCCAAGAGAATTTCTGTAGATGAAGCTTTGCAGCATCCTTATATCAATGTTTGGTATGACCCCCTGGAAGCTGATGCACCACCACCAAAGATCCCAGACAAACAACTGGATGAGAGAGAACATACCATAGAAGAATGGAAAGAGCTCATCTACAAGGAGGTTTTGGACTGGGAGGACAGTAGCAGGAATCGGCGGGTGGAACAGCACCAACATATAAATGATTGCTGACTCGTAATAAATTATCGATGTTGGGAAAAAAAAAAAAAAAAGAAAAAAAAAAAAAAAAATCAAAATAAAAAATAAAAAAAAGAAAAATCAAAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA	Refseq >NM_001086715\|Xenopus laevis mitogen-activated protein kinase 8 (mapk8), mRNA GTCGACGCACCACCAGGAGTGGAGCCTGCGGCTTAATTTGACCCAACACGGGAAAACTTACCAGGTCCGGACATAGTGAGGATTGACAGATTGAAGATCTTTCTTGATTCTATGGGTGGTGGTGCATGGCCGTTCTTAGTTGGTGGAGTGATTTGTCTGGTTAATTCCGTTAACGAACGAGACCTCGACCTGCTAAATAGTTGACTGAATCTTTTTGGTTGGGATTGACTTCTTAGAGGGACTTTTTGTGGTTAGCACACTCCCTTAGTTAACTGTGCGTCACACTTGCGTATCCCGTCCTTGCTCGTCACTCCCCTACGATGGCTACGTGTAGCGTCACTGCGCTTCCATACGTGTGGTGTGATGTCACAGCATCGCGAGATGGTACTTTGTGACGTCTGGATTAGCTGTCCGGCAGGAGTCAAGGAGCTAGACGTTAACGGAGCTGCGGGGCTTTTAAACAGCGATCCGTTTCTGATTTAGAGAAGCTTGGTTTGAATGAAGCCACTGGGGTAAGTGCTCGTGTAATCATGAGCCGAAGCAAGCGTGACAGCAATTTCTCTGTCTTTGAGATAGGAGATTCCACTTTCACTGTTCTCAAGAGATACCAAAATCTGAAGCCTATTGGATCTGGAGCCCAGGGAATAGTATGTGCTGCCTTTGATGCAGTTCTGGAGAGACACGTTGCCATCAAAAAACTAAGCCGGCCATTCCAGAATCAAACCCATGCCAAGAGAGCTTATCGGGAACTTGTGCTTATGAAATGTGTCAATCACAAGAATATAATTGGACTCCTAAATGTCTTTACTCCTCAGAAGTCTTTAGAAGAGTTTCAGGACCTGTACATTGTTATGGAGCTTATGGATGCCAACCTGTGCCAAGTGATACAGATGGAATTGGACCATGAGCGCATGTCCTACCTGCTGTACCAGATGTTATGTGGCATCAAACACCTACATTCTGCTGGGATCATCCACAGGGATTTAAAGCCAAGTAACATTGTAGTTAAATCTGACTGCACTCTCAAGATTCTTGATTTTGGACTTGCACGGACAGCAGGGACCAGTTTTATGATGACACCTTACGTTGTTACTCGTTACTATAGAGCTCCAGAAGTCATCTTGGGAATGGGATATAAGGAAAACGTTGACATTTGGTCTGTGGGTTGCATCTTGGGAGAGATGATCAAAGGTGGTGTGTTATTCCCCGGCACAGACCATATCGACCAGTGGAATAAAGTAATTGAACAGTTGGGCACGCCATGTACAGAATTCATGAAAAAATTACAGCCAACAGTGAGGACATATGTAGAAAATAGACCCAAATACGCAGGTTACAGCTTTGAGAAACTCTTCCCTGATGTTTTATTCCCAGCAGACTCTGAGCACAATAAGTTAAAAGCTAGCCAAGCCAGAGATCTGCTGTCGAAAATGCTAGTAATAGATGCATCCAAGAGAATCTCTGTAGATGACGCTTTGCAGCATCCTTATATCAATGTTTGGTACGACCCCCTGGAAGCCGAAGCACCACCACCAAAGATTCCAGACAAACAATTGGATGAGCGAGAACACACTATAGAAGAATGGAAAGAGCTCATATACAAGGAAGTTTTGGACTGGGAAGAGAGAGCTAAGAATGGAGTAATCCGTGGTCAGCCAGCCCCTTTAGGTGCAGCAGTAACTGATGGTTCCCAGGCTCATACCTCCTCATCATCAGGCGACGCTTCCTCCATGTCAACAGATCCAACTCTGCCCTCAGACACAGACAGCAGCCTTGAAACCTCTGCAGGAACCCTGGGTTGCTGTCGATGACTTATTGGCAGAGGGGTGGGAGGGAGGGATATAGGCCGCAGGGAGGAGGTTGTGGGGACCTCTAGGGTAGCACAGTTTGACTGGGGAAAATGCCACTTGTATTATTATCTATTGATTATCATTAACCCCTTAGTTGCCAGATACTTGTGATTGCATTGCAGTCAAAGGTCTGAAAGATGGATTAGATTCCAGTTTCAATTTAAGTACTGGGAGGAGCCACAACTACTCCTTACTCTTCACCAGATTTAAATTGGTTAAGAGGTGTGGTTGCATTTTTAATTTTAGTGCTGTAATTTGAACACTTAAGTGCTGGAGGGTTTAAAGAAAAGCTGCCATAAATATGTATTGTATTTTTATTTCTGTTTTGTGCGGGGGGAGGTGGGCTTAATGCTCCAACTTTTTGAGAAAAGGTCACTTTGGTCCTGATTGTCTTGAATTTTTTTTTTTATTTTTTTTTTCCGTTTCCATGCTGGTGCTGCTCAGTTTTTATGTTTTATCTTCTAAAATTATACAGATTGTTCCATATTTTTATTAATTTAATTTTTCGTAATGGGAGTTATTTTCACACATAATGTGCCAGTAATCCTAAAGCAGGCAGAGCTTTCTGTTTACTTCTGATCATGTAATCAAGCTGTGGCAACTTAGTTGTTGGTGCATCCACTCTTGCAATATCTTGGCTGTCATATTGATTTGGATTATCTGACAGAATTCTGTCTTTTGAGTGGAAACAGCCTTTTACATATCCCCACCAACACTTTGCACTGTAATGTGCAACGGCCACCTTTGAAAACAAAGGGGTATGCAGATAAAAAGGTATAAAAAAAACAATTAAAAAGGCATATTTTTTTATATTTCATGCTTTAATTTGCATCCTAATATTGAATAATAATTTACATTCAATTTATCACTTTGGTGGTTATTATAAAGGTGAATGTGAAATATTACAAACAGACACCGGCAGCAGTCTTAAGCGAGCCCTCCCCTGACAGCAAATGCATTTTATATTTATTCAAGATGGGTAAAACAAAAAAGACTTTGTTACTCAGAATAGATGCTATTCTTATTACATTTTGATAATTTTGTTCATCCGTGAGAATGAATACACCAGAGTAGCCTCCCTTGTTCTGCCTGTGCAGTGGATACAGTTGTTCCATAATTCCACAGTTTAGTCTTTTTACCCTGCGTGGGAGAGCAATCTTCACCTTGTTAGAGTCCTTTTCTCAGTCTAGATGTATTGTATCACTGCTTGTTAATTCCTCTTCTGTTTACGATAGCCGAACAGATCAATCAATTAATTAAATGTGTTCTGCCCTCGCTTGCAGGACAGTAGCAGGAATCAACGGGTGGAACAGCACGAACATATAAATGATTGCTGACGCGTAATAAATGATCGATGTTGGGAAAACAAAAGTCGAC
Protein		Refseq >NP_001123415\|mitogen-activated protein kinase 8 [Xenopus (Silurana) tropicalis] MSRSKRDSNFSVFEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLERHVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDLYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCILGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPLEADAPPPKIPDKQLDEREHTIEEWKELIYKEVLDWEDSSRNRRVEQHQHINDC	Refseq >NP_001080184\|mitogen-activated protein kinase 8 [Xenopus laevis] MSRSKRDSNFSVFEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAFDAVLERHVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDLYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCILGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCTEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDDALQHPYINVWYDPLEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVLDWEERAKNGVIRGQPAPLGAAVTDGSQAHTSSSSGDASSMSTDPTLPSDTDSSLETSAGTLGCCR UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase

Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.7537	Xl.8740
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		3 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	MAPK8
mouse		MGI	Mapk8	All(5) Targeted, knock Out(2) Targeted, other(3)
zebrafish		ZFIN ZFIN	mapk8a mapk8b	5 Lines(s)

Publications
First:		Activation of mitogen-activated protein kinase cascades by p21-activated protein kinases in cell-free extracts of Xenopus oocytes. [J Biol Chem 1995]
Most recent:		β-Arrestin 1 mediates non-canonical Wnt pathway to regulate convergent extension movements. [Biochem Biophys Res Commun 2013]
		View All Papers 19 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		3-phosphoinositide-dependent protein kinase activity AMP-activated protein kinase activity ATP binding More[+] DNA-dependent protein kinase activity G-protein coupled receptor kinase activity IkappaB kinase activity JUN kinase activity JUN kinase kinase activity JUN kinase kinase kinase activity Janus kinase activity MAP kinase 1 activity MAP kinase 2 activity MAP kinase activity MAP kinase kinase activity MAP kinase kinase kinase activity MAP kinase kinase kinase kinase activity MAP/ERK kinase kinase activity MP kinase activity NF-kappaB-inducing kinase activity SAP kinase activity atypical protein kinase C activity cGMP-dependent protein kinase activity calcium-dependent protein kinase C activity calmodulin-dependent protein kinase activity casein kinase I activity casein kinase activity cobinamide kinase activity cyclic nucleotide-dependent protein kinase activity cyclin-dependent protein kinase activating kinase activity cyclin-dependent protein kinase activating kinase regulator activity cyclin-dependent protein kinase activity cyclin-dependent protein kinase regulator activity diacylglycerol-activated phospholipid-dependent protein kinase C activity elongation factor-2 kinase activity eukaryotic elongation factor-2 kinase activator activity eukaryotic elongation factor-2 kinase regulator activity eukaryotic translation initiation factor 2alpha kinase activity galactosyltransferase-associated kinase activity glycogen synthase kinase 3 activity multifunctional calcium- and calmodulin-regulated protein kinase activity non-membrane spanning protein tyrosine kinase activity phenol kinase activity phosphatidylinositol phosphate kinase activity phosphofructokinase activity phosphoinositide 3-kinase activity phosphorylase kinase activity phosphorylase kinase regulator activity phosphotransferase activity, alcohol group as acceptor protein kinase C activity protein kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity receptor signaling protein serine/threonine kinase activity receptor signaling protein tyrosine kinase activity ribosomal protein S6 kinase activity transmembrane receptor protein kinase activity transmembrane receptor protein serine/threonine kinase activity transmembrane receptor protein tyrosine kinase activity
Biological:		protein amino acid phosphorylation
Cellular Component:
EC:		Phosphotransferases with an Alcohol Group as Acceptor
KOG:		[T] Jun-N-terminal kinase (JNK)

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		StrEns.8093.1.S1_at	Xl.8740.1.S1_at
Affymetrix 2.0			Xl2.8740.1.S1_at

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