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Summary Expression Gene Literature (56) GO Terms (46) Nucleotides (324) Proteins (44) Interactants (77) Wiki
XB-GENEPAGE-1218922
Gene Symbol:
nlk.2

Gene Name:
nemo-like kinase, gene 2

Synonyms:
xnlk ( Add synonyms , Nomenclature history )

Gene Function:
serine/threonine kinase

Protein Function :
Negatively regulates Wnt/beta-catenin-signaling during development. Plays a role together with sox11 in neural induction during early embryogenesis. Involved in TGFbeta-mediated mesoderm induction in e...[+]



Interactants:
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Diseases: 


External Links:
 
Xenbase Gene ID XB-GENE-1218923 XB-GENE-17333536 XB-GENE-1218927
Gene Symbol nlk.2 nlk.2.L nlk.2.S
Chromosome Chr9 Scaffold22 Scaffold29
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100144684
108703801
398295
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein RefSeq Swiss-Prot  More.. NCBI Protein RefSeq Swiss-Prot  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine nlk.2 nlk.2.L nlk.2.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards NLK OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Nlk MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Nlk Ensembl
zebrafish
ZFIN, AGR nlk1 ZFIN Ensembl
chicken
GEISHA NLK Ensembl
fruit fly
worm
Publications
First The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF., Nature 1999  
Most Recent Nemo-like kinase, an essential effector of anterior formation, functions downstream of p38 mitogen-activated protein kinase., Mol Cell Biol 2010    
All View All Papers 2 paper(s) referencing morpholinos
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 43 terms 0 term 20 terms
PANTHER nlk.2
KEGG Pathways K04468 [+] K04468
KOG [T] Nemo-like MAPK-related serine/threonine protein kinase
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks nlk.2
Morpholinos nlk.2 MO1 nlk.2 MO1 nlk.2 MO1
ORFs nlk.2.S ORF1
Clones Horizon Source BioScience Horizon Horizon Source BioScience
Plasmids Addgene Addgene

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