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Summary Expression Gene Literature (16) GO Terms (13) Nucleotides (39) Proteins (25) Interactants (175) Wiki
XB-GENEPAGE-1221136
Gene Symbol: invs

Gene Name: inversin

Synonyms: NPH2 , NPHP2 , inversin , nephrocystin-2 , invs-a , invs-b ( Add synonyms , Nomenclature history )

Gene Function: multiple ankyrin domains and two IQ calmodulin-binding domains: functions in cilia formation and left-right axis establishment

Protein Function :
Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting...[+]

Interactants: Loading ...
Disease Ontology: nephronophthisis 2

OMIM Diseases: NEPHRONOPHTHISIS 2; NPHP2

 
Xenbase Gene ID XB-GENE-1221137 XB-GENE-6255451 XB-GENE-1221139
Gene Symbol invs invs.L invs.S
Chromosome Chr08 Scaffold36 chr8S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
Entrez Gene
mRNA NCBI Nucleotide RefSeq RefSeq
Protein NCBI Protein TrEMBL RefSeq TrEMBL Swiss-Prot RefSeq TrEMBL Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression
Data Mining tropicalis laevis.L laevis.S
XenMine invs invs.L invs.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards INVS OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Invs MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR invs ZFIN Ensembl
chicken
GEISHA INVS Ensembl
fruit fly
worm
WORMBASE
Publications
First The left-right determinant inversin has highly conserved ankyrin repeat and IQ domains and interacts with calmodulin., Hum Genet 2002  
Most Recent The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery., Nat Genet 2016                                
All View All Papers 1 paper(s) referencing morpholinos 4 paper(s) referencing OMIMs 6 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 8 terms 5 terms 5 terms
PANTHER invs
KEGG Pathways K19626 K19626 K19626
KOG [R] FOG: Ankyrin repeat
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
Dharmacon Dharmacon Dharmacon
Antibody Invs Ab1 Invs Ab1 Invs Ab1
Morpholino invs MO1 invs MO1 invs MO1
Affymetrix 1.0 StrEns.7535.1.S1_at Xl.21601.1.S1_at [+]
Affymetrix 2.0 Xl2.29849.1.S1_a_at Xl2.21601.1.S1_at

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
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Version: 4.12.0


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