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Summary Expression Gene Literature (27) GO Terms (31) Nucleotides (111) Proteins (43) Interactants (400) Wiki
XB-GENEPAGE-494739
Gene Symbol:
mecp2

Gene Name:
methyl-CpG binding protein 2

Synonyms:
( Add synonyms , Nomenclature history )

Gene Function:
methyl-CpG binding transcription factor

Protein Function :
Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and...[+]


InterPro :
APS kinase , Sulphate adenylyltransferase , PUA-like sf , P-loop NTPase [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
non-syndromic X-linked intellectual disability [+]

OMIM:
ANGELMAN SYNDROME; AS [+]

External Links:
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Xenbase Gene ID XB-GENE-494740 XB-GENE-17346751 XB-GENE-494744
Gene Symbol mecp2 mecp2.L mecp2.S
Chromosome Chr8 Scaffold50 chr8S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100216110
108704791
398087
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein RefSeq  More.. NCBI Protein NCBI Protein RefSeq  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine mecp2 mecp2.L mecp2.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC, AGR, Monarch, OMIM, GeneCards MECP2 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Mecp2 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Mecp2 Ensembl
zebrafish
ZFIN, AGR mecp2 ZFIN Ensembl
chicken
GEISHA MECP2 Ensembl
fruit fly
Publications
First Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription., Nat Genet 1998  
Most Recent Rare Diseases of Neurodevelopment: Maintain the Mystery or Use a Dazzling Tool for Investigation? The Case of Rett Syndrome., Neuroscience 2020  
All View All Papers 3 paper(s) referencing morpholinos 2 paper(s) referencing OMIMs 3 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 30 terms 0 term 6 terms
PANTHER mecp2
KEGG Pathways K11588 K11588
KOG [KB] Methyl-CpG binding transcription regulators
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks mecp2
Antibodies Mecp2 Ab1 Mecp2 Ab1
Morpholinos mecp2 MO2 mecp2 MO2
Clones Horizon Source BioScience Horizon Horizon Source BioScience
Plasmids Addgene Addgene

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