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Summary Expression Gene Literature (38) GO Terms (17) Nucleotides (28) Proteins (17) Interactants (465) Wiki
Gene Symbol:

Gene Name:
forkhead box H1, gene 2

fast3 , XFast-3 ( Add synonyms , Nomenclature history )

Gene Function:
winged helix transcription factor

Protein Function :
Transcriptional activator. Upon TGF-beta induction, forms a transcriptionally active complex with smad2 and smad4 called activin-responsive factor 2 (ARF2), which binds a site on the mix-B/mix.2 promot...[+]

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Disease Ontology:
holoprosencephaly 1


External Links:
Xenbase Gene ID XB-GENE-478064 XB-GENE-6461998 XB-GENE-17342561
Gene Symbol foxh1.2 foxh1.2.L foxh1.2.S
Chromosome scaffold_2250 chr6L
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 7.1 Version 9.1
CDS Gene model
Entrez Gene 100337554
mRNA RefSeq
Protein RefSeq Swiss-Prot
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine foxh1.2 foxh1.2.L foxh1.2.S
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
HGNC AGR, OMIM:Gene, GeneCards FOXH1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
MGI, AGR Foxh1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
RGD, AGR Foxh1 Ensembl
ZFIN, AGR foxh1 ZFIN Ensembl
fruit fly
First The transcriptional role of Smads and FAST (FoxH1) in TGFbeta and activin signalling., Mol Cell Endocrinol 2001  
Most Recent Generation of a FOXH1 homozygous knockout human embryonic stem cell line by CRISPR/Cas9 system., Stem Cell Res 2020    
All View All Papers 11 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 1 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 10 terms 10 terms 0 term
PANTHER foxh1.2
KEGG Pathways K09400
KOG [K] Transcription factor of the Forkhead/HNF3 family
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks
Morpholinos (on-target & off-target) foxh1.2 MO1
Clones Horizon Source BioScience
Plasmids Addgene Addgene

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