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Summary Expression Gene Literature (30) GO Terms (34) Nucleotides (76) Proteins (32) Interactants (371) Wiki
XB-GENEPAGE-478209
Gene Symbol: fzd4

Gene Name: frizzled class receptor 4

Synonyms: Fz-4 , Xfz4 , frizzled-4 , frizzled 4 , frizzled4 , Fz4 ( Add synonyms , Nomenclature history )

Gene Function: transmembrane receptor in the wnt signaling pathway

Protein Function :
Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear...[+]

Interactants: Loading ...
Diseases:  Disease Ontology: exudative vitreoretinopathy

OMIM: EXUDATIVE VITREORETINOPATHY 1; EVR1

External Disease Links: ClinVar, MalaCards, KEGG Disease, DECIPHER
1/4
 
Xenbase Gene ID XB-GENE-478210 XB-GENE-17342547 XB-GENE-865153
Gene Symbol fzd4 fzd4.L fzd4.S
Chromosome Chr02 chr2L chr2S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.1 Version 9.2
CDS Gene model Gene model
Entrez Gene 100497693
399192
mRNA NCBI Nucleotide RefSeq
Protein NCBI Protein TrEMBL RefSeq Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining tropicalis laevis.L laevis.S
XenMine fzd4 fzd4.L fzd4.S
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards FZD4 OMIM Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Fzd4 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR fzd4 ZFIN Ensembl
chicken
GEISHA FZD4 Ensembl
fruit fly
worm
WORMBASE
Publications
First Xenopus frizzled 4 is a maternal mRNA and its zygotic expression is localized to the neuroectoderm and trunk lateral plate mesoderm., Mech Dev 2000    
Most Recent Transcriptome profiling reveals male- and female-specific gene expression pattern and novel gene candidates for the control of sex determination and gonad development in Xenopus laevis., Dev Genes Evol 2019          
All View All Papers 2 paper(s) referencing morpholinos 3 paper(s) referencing OMIMs 3 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 9 terms 0 term 32 terms
PANTHER fzd4
KEGG Pathways K02354 K02354
KOG [T] Smoothened and related G-protein-coupled receptors
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks fzd4
Morpholinos Fzd4 MO1 Fzd4 MO1 Fzd4 MO1
Clones Horizon Source BioScience Horizon Source BioScience

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
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Version: 4.13.1
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