Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (26) GO Terms (0) Nucleotides (266) Proteins (29) Interactants (259) Wiki
XB-GENEPAGE-478638

Gene Symbol: dact1

Gene Name: dishevelled-binding antagonist of beta-catenin 1

Synonyms: XDpr , Dapper , dapper 1 , frodo , dapper1 , dpr , dpr1 , hdpr1 , thyex3 , dact1-b , dact1-a ( Add Xenopus synonyms , Nomenclature history )

Gene Function: antagonist of beta-catenin and c-jun N-terminal kinase signaling

Protein Function :
Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH ...[+]

Interactants: Loading ...
Disease Ontology:

OMIM Diseases: TOWNES-BROCKS SYNDROME 2; TBS2

 
Xenbase Gene ID XB-GENE-478639 XB-GENE-478643 XB-GENE-6251608
Gene Symbol dact1 dact1.L dact1.S
Chromosome Chr08 chr8L chr8S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
Entrez Gene
mRNA RefSeq NCBI Nucleotide RefSeq
Protein RefSeq Swiss-Prot NCBI Protein TrEMBL Swiss-Prot RefSeq TrEMBL Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine dact1 dact1.L dact1.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards DACT1 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Dact1 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR dact1 ZFIN Ensembl
chicken
GEISHA DACT1 Ensembl
fruit fly
worm
WORMBASE
Publications
First Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation., Dev Cell 2002    
Most Recent RARĪ³ is required for mesodermal gene expression prior to gastrulation in Xenopus., Development 2018  
All View All Papers 2 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 1 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 0 term 0 term 0 term
PANTHER dact1
KEGG Pathways K22154 K22154 K22154
KOG
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
Dharmacon Dharmacon Dharmacon
Morpholino dact1 MO1 , dact1 MO2 , dact1 MO3 dact1 MO1 , dact1 MO2 , dact1 MO3 dact1 MO1 , dact1 MO2 , dact1 MO3
ORF dact1.S ORF1
Affymetrix 1.0 Str.3375.1.S1_at [+] Xl.7602.1.S2_at Xl.19185.1.S1_at
Affymetrix 2.0 Xl2.19185.1.S1_at

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.11.3


Major funding for Xenbase is provided by grant P41 HD064556