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Summary Expression Gene Literature (23) GO Terms (9) Nucleotides (262) Proteins (28) Interactants (132) Wiki
XB-GENEPAGE- 478638

Gene Symbol: dact1

Gene Name: dishevelled-binding antagonist of beta-catenin 1

Synonyms: XDpr , Dapper , dapper 1 , frodo , dapper1 , dpr , dpr1 , hdpr1 , thyex3 , dact1-b , dact1-a
Add Xenopus synonyms , Nomenclature history


Gene Function: antagonist of beta-catenin and c-jun N-terminal kinase signaling

Protein Function:
Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH ...[+]


Interactants: YYY

OMIM Disease Associations:
 
Xenbase Gene ID XB-GENE-478639 XB-GENE-478643 XB-GENE-6251608
Gene Symbol dact1 dact1.L dact1.S
Chromosome scaffold_8 chr8L chr8S
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq NCBI Nucleotide Refseq
Protein Refseq Swiss-Prot NCBI Protein TrEMBL Refseq TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
GBrowse
tropicalis genome v7.1 gene model
GBrowse
laevis genome v9.1 gene model
GBrowse
laevis genome v9.1 gene model
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.3375 Xl.7602 Xl.19185
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Images 3 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine dact1 dact1.L dact1.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards DACT1 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Dact1 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN dact1 ZFIN Ensembl
chicken
GEISHA DACT1 Ensembl
fruit fly
worm
WORMBASE
Publications
First: Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation. [Dev Cell 2002]
Most recent: Heterozygous Pathogenic Variant in DACT1 Causes an Autosomal-Dominant Syndrome with Features Overlapping Townes-Brocks Syndrome. [Hum Mutat 2017]
View All Papers 2 paper(s) referencing morpholinos
Functional Ontologies tropicalis laevis.L laevis.S
GO 9 terms 0 term 0 term
EC
PANTHER dact1
KEGG Pathways
KOG
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience Source BioScience
Morpholino dact1 MO1 , dact1 MO2 dact1 MO1 , dact1 MO2 dact1 MO1 , dact1 MO2
ORF dact1 ORF1
Affymetrix 1.0 Str.3375.1.S1_at [+] Xl.7602.1.S2_at Xl.19185.1.S1_at
Affymetrix 2.0 Xl2.19185.1.S1_at

Symbol legend[+]

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