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Summary Expression Gene Literature (94) GO Terms (19) Nucleotides (66) Proteins (39) Interactants (1378) Wiki
XB-GENEPAGE-478760
Gene Symbol:
six3

Gene Name:
SIX homeobox 3

Synonyms:
XSix3 , hpe2 , six3-a , six3-b , xsix3.1 , xsix3.2 ( Add synonyms , Nomenclature history )

Gene Function:
homeodomain transcription factor

Protein Function :


InterPro :
Znf C2H2 sf , Znf C2H2 type , Aminopeptidase N-like N , TAF2 [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
holoprosencephaly 2

OMIM:
HOLOPROSENCEPHALY 2; HPE2 [+]

External Links:
1/6
 
Xenbase Gene ID XB-GENE-478761 XB-GENE-478765 XB-GENE-17343547
Gene Symbol six3 six3.L six3.S
Chromosome Chr5 chr5L chr5S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100493798
373739
398146
mRNA NCBI Nucleotide RefSeq NCBI Nucleotide
Protein NCBI Protein NCBI Protein RefSeq  More.. NCBI Protein NCBI Protein  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine six3 six3.L six3.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards SIX3 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Six3 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Six3 Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR six3a six3b ZFIN Ensembl
chicken
GEISHA SIX3 Ensembl
fruit fly
worm
Publications
First Ectopic lens induction in fish in response to the murine homeobox gene Six3., Mech Dev 1996  
Most Recent TMEM79/MATTRIN defines a pathway for Frizzled regulation and is required for Xenopus embryogenesis., Elife 2020                                                                          
All View All Papers 25 paper(s) referencing morpholinos 3 paper(s) referencing OMIMs 8 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 19 terms 5 terms 5 terms
PANTHER six3
KEGG Pathways K19473 K19473 K19473
KOG [K] Transcription factor SIX and related HOX domain proteins
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks six3
Morpholinos six3 MO1 , six3 MO2 , six3 MO3 six3 MO1 , six3 MO2 , six3 MO3 six3 MO1 , six3 MO2 , six3 MO3
Clones Horizon Horizon Source BioScience Horizon
Plasmids Addgene Addgene

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