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Summary Expression Gene Literature (17) GO Terms (22) Nucleotides (97) Proteins (38) Interactants (142) Wiki
XB-GENEPAGE-479045
Gene Symbol:
smurf1

Gene Name:
SMAD specific E3 ubiquitin protein ligase 1

Synonyms:
xSMURF1 ( Add synonyms , Nomenclature history )

Gene Function:
ubiquitin protein ligase

Protein Function :
E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of smad1 and smad5, 2 receptor-regulated SMADs specific for the BMP pathw...[+]



Interactants:
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Diseases: 


External Links:
 
Xenbase Gene ID XB-GENE-479046 XB-GENE-479050 XB-GENE-17332942
Gene Symbol smurf1 smurf1.L smurf1.S
Chromosome Chr09 chr9_10L chr9_10S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100491582
398131
108703087
mRNA NCBI Nucleotide RefSeq NCBI Nucleotide
Protein NCBI Protein RefSeq Swiss-Prot
Genomic
tropicalis laevis.L laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining tropicalis laevis.L laevis.S
XenMine smurf1 smurf1.L smurf1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards SMURF1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Smurf1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Smurf1 Ensembl
zebrafish
ZFIN, AGR smurf1 ZFIN Ensembl
chicken
GEISHA SMURF1 Ensembl
fruit fly
worm
Publications
First A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation., Nature 1999  
Most Recent Coordinated regulation of the dorsal-ventral and anterior-posterior patterning of Xenopus embryos by the BTB/POZ zinc finger protein Zbtb14., Dev Growth Differ 2018            
All View All Papers 6 paper(s) referencing morpholinos
Functional Ontologies tropicalis laevis.L laevis.S
GO 16 terms 11 terms 2 terms
PANTHER smurf1
KEGG Pathways K04678 K04678 K04678
KOG [O] Ubiquitin protein ligase RSP5/NEDD4
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks smurf1
Antibodies Smurf1 Ab1 , Smurf1 Ab2 Smurf1 Ab1 , Smurf1 Ab2
Morpholinos smurf1 MO1 smurf1 MO1 smurf1 MO1
ORFs smurf1.L ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon

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