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Summary Expression Gene Literature (368) GO Terms (17) Nucleotides (207) Proteins (35) Interactants (1450) Wiki
XB-GENEPAGE-479317
Gene Symbol:
notch1

Gene Name:
notch 1 receptor

Synonyms:
notch , xotch , xnotch , notch-1 , xnotch1 , x-notch-1 ( Add synonyms , Nomenclature history )

Gene Function:
signal transduction, receptor for delta class ligands

Protein Function :
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellul...[+]



Interactants:
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Diseases: 


Disease Ontology:
Adams-Oliver syndrome [+]

OMIM:
AORTIC VALVE DISEASE 1; AOVD1 [+]

External Links:
GEO Series :
GSE76342.
1/5
 
Xenbase Gene ID XB-GENE-479318 XB-GENE-17342057 XB-GENE-865261
Gene Symbol notch1 notch1.L notch1.S
Chromosome Chr02 chr8L chr8S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100037842
108698191
394367
mRNA RefSeq NCBI Nucleotide RefSeq
Protein RefSeq Swiss-Prot  More.. NCBI Protein TrEMBL RefSeq Swiss-Prot  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine notch1 notch1.L notch1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards NOTCH1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Notch1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Notch1 Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR notch1a notch1b ZFIN Ensembl
chicken
GEISHA NOTCH1 Ensembl
fruit fly
worm
Publications
First Cell patterning in pigment-chimeric eyes in Xenopus: germinal transplants and their contributions to growth of the pigmented retinal epithelium., Proc Natl Acad Sci U S A 1987            
Most Recent Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos., Sci Rep 2020                        
All View All Papers 53 paper(s) referencing morpholinos 6 paper(s) referencing OMIMs 14 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 15 terms 9 terms 11 terms
PANTHER notch1
KEGG Pathways K02599 K02599 K02599
KOG [O] 26S proteasome regulatory complex, subunit PSMD10
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks notch1
Antibodies Notch1 AB1 Notch1 AB1 Notch1 AB1
Morpholinos notch1 MO1 notch1 MO1 notch1 MO1
Clones Horizon Source BioScience Horizon EXRC Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
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