Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (114) GO Terms (3) Nucleotides (137) Proteins (20) Interactants (586) Wiki
XB-GENEPAGE- 479959

Gene Symbol: casp3

Gene Name: caspase 3

Synonyms: CASP-3 , Apopain , xCPP32 , caspase 3 , caspase-3
Add Xenopus synonyms , Nomenclature history

Gene Function: apoptotic cysteine protease

Protein Function:
Important mediator of apoptosis. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond.


Interactants: YYY

OMIM Disease Associations:
 
Xenbase Gene ID XB-GENE-479960 XB-GENE-17335907 XB-GENE-865327
Gene Symbol casp3 casp3.L casp3.S
Chromosome Chr01 Scaffold41523
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 8.0 JBrowse 8.0 GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq Refseq Refseq
Protein Refseq TrEMBL Refseq TrEMBL Refseq Swiss-Prot TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
GBrowse
tropicalis genome v8.0 gene model
GBrowse
laevis genome v7.2 gene model
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.11713 Xl.17957
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Images 16 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine casp3 casp3.L casp3.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards CASP3 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Casp3 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN ZFIN casp3a casp3b ZFIN Ensembl
chicken
GEISHA CASP3 Ensembl
fruit fly
worm
WORMBASE
Publications
First: Induction of apoptosis and CPP32 expression by thyroid hormone in a myoblastic cell line derived from tadpole tail. [J Biol Chem 1997]
Most recent: Neuronal degeneration and regeneration induced by axotomy in the olfactory epithelium of Xenopus laevis. [Dev Neurobiol 2017]
View All Papers 20 paper(s) referencing morpholinos
Functional Ontologies tropicalis laevis.L laevis.S
GO 3 terms 3 terms 3 terms
EC Cysteine endopeptidases
PANTHER casp3
KEGG Pathways K02187 K02187 K02187
KOG [D] Caspase, apoptotic cysteine protease
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones     EXRC - 1 clone(s)
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience
Antibody Casp3 Ab1 , Casp3 Ab2 , Casp3 Ab3 , Casp3 Ab4 , Casp3 Ab5 , Casp3 Ab6 Casp3 Ab3 , Casp3 Ab1 , Casp3 Ab4 Casp3 Ab1 , Casp3 Ab2 , Casp3 Ab3 , Casp3 Ab4 , Casp3 Ab5 , Casp3 Ab6
Morpholino casp3 MO1 , casp3 MO2 casp3 MO1 , casp3 MO2 casp3 MO1 , casp3 MO2
ORF casp3 ORF1
Affymetrix 1.0 Str.20292.1.S1_at [+] Xl.17957.1.S1_at
Affymetrix 2.0 Xl2.17957.1.S2_at [+]

Symbol legend[+]

My Xenbase: [ Log-in / Register ]
version: [4.5.0]

Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556