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Summary Expression Gene Literature (117) GO Terms (13) Nucleotides (157) Proteins (34) Interactants (666) Wiki
Gene Symbol:

Gene Name:
caspase 3, gene 2

CASP-3 , Apopain , xCPP32 , caspase 3 , caspase-3 ( Add synonyms , Nomenclature history )

Gene Function:
apoptotic cysteine protease

Protein Function :
Important mediator of apoptosis. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond.

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External Links:
Xenbase Gene ID XB-GENE-479960 XB-GENE-17335907 XB-GENE-865327
Gene Symbol casp3.2 casp3.2.L casp3.2.S
Chromosome Chr1 chr1L chr1S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100151728
mRNA RefSeq RefSeq RefSeq
Protein NCBI Protein RefSeq  More.. NCBI Protein RefSeq  More.. NCBI Protein RefSeq  More..
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine casp3.2 casp3.2.L casp3.2.S
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
HGNC AGR, OMIM:Gene, GeneCards CASP3 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
MGI, AGR Casp3 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
RGD, AGR Casp3 Ensembl
ZFIN, AGR ZFIN, AGR casp3a casp3b ZFIN Ensembl
fruit fly
First Induction of apoptosis and CPP32 expression by thyroid hormone in a myoblastic cell line derived from tadpole tail., J Biol Chem 1997  
Most Recent Mcl1 protein levels and Caspase-7 executioner protease control axial organizer cells survival., Dev Dyn 2020                
All View All Papers 20 paper(s) referencing morpholinos 4 paper(s) referencing OMIMs 9 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 13 terms 3 terms 3 terms
PANTHER casp3.2
KEGG Pathways K02187 K02187 K02187
KOG [D] Caspase, apoptotic cysteine protease
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks casp3.2
Antibodies Casp3 Ab1 , Casp3 Ab2 , Casp3 Ab3 , Casp3 Ab4 , Casp3 Ab5 , Casp3 Ab6 Casp3 Ab3 , Casp3 Ab1 , Casp3 Ab4 Casp3 Ab1 , Casp3 Ab2 , Casp3 Ab3 , Casp3 Ab4 , Casp3 Ab5 , Casp3 Ab6
Morpholinos casp3 MO1 , casp3 MO2 casp3 MO1 , casp3 MO2 casp3 MO1 , casp3 MO2
ORFs casp3.S ORF1
Clones Horizon Source BioScience Horizon EXRC Horizon Source BioScience
Plasmids Addgene Addgene

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