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XB-GENEPAGE-
479959
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Gene Symbol: casp3
Gene Name: caspase 3 Synonyms: CASP-3 , Apopain , xCPP32 , caspase 3 , caspase-3 Add Xenopus synonyms , Nomenclature history Gene Function: apoptotic cysteine protease Protein Function  :
Important mediator of apoptosis. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond.
Interactants: Loading ... 
Disease Ontology: OMIM Diseases: |
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| Xenbase Gene ID | XB-GENE-479960 | XB-GENE-17335907 | XB-GENE-865327 | ||||
| Gene Symbol | casp3 | casp3.L | casp3.S | ||||
| Chromosome | Chr01 | Scaffold41523 | |||||
| Molecules | tropicalis | laevis.L | laevis.S | ||||
| Gene |
Genomic sequence
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| CDS |
Gene model
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Entrez Gene
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Entrez Gene
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Entrez Gene
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| mRNA |
Refseq
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Refseq
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Refseq
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| Protein
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Refseq
TrEMBL
TrEMBL
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Refseq
TrEMBL
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Refseq
Swiss-Prot
TrEMBL
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| Genomic | tropicalis | laevis.L | laevis.S | ||||
| Genome Browser |
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| Links |
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| Genomic Synteny | Genomicus PANTHER | ||||||
| Expression | tropicalis | laevis.L | laevis.S | ||||
| Ensembl | Ensembl | ||||||
| UniGene | Str.11713 | Xl.17957 | |||||
| RNA-Seq profile | Stage profile: |
Stage profile:
Tissue heatmap:
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| Experimental regulation |
Regulation heatmap:
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| Images | 17 expression image(s) for tropicalis and laevis | ||||||
| Data Mining | tropicalis | laevis.L | laevis.S | ||||
| XenMine | casp3 | casp3.L | casp3.S | ||||
| Phenotype | tropicalis | laevis.L | laevis.S | ||||
| Smith Morpholino Screen | |||||||
| Orthology |
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| human |
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| mouse |
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| zebrafish |
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| chicken |
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| fruit fly |
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| worm |
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| Publications | |||||||
| First: | Induction of apoptosis and CPP32 expression by thyroid hormone in a myoblastic cell line derived from tadpole tail. [J Biol Chem 1997] | ||||||
| Most recent: |
A model for investigating developmental eye repair in Xenopus laevis. [Exp Eye Res 2018]
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| View All Papers 20 paper(s) referencing morpholinos 4 paper(s) referencing OMIMs 6 paper(s) referencing Disease Ontology | |||||||
| Functional Ontologies | tropicalis | laevis.L | laevis.S | ||||
| GO | 8 terms | 3 terms | 3 terms | ||||
| PANTHER | casp3 | ||||||
| KEGG Pathways | K02187 | K02187 | K02187 | ||||
| KOG |
[D] Caspase, apoptotic cysteine protease
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| Reagents | tropicalis | laevis.L | laevis.S | ||||
| CRISPR / TALEN | CRISPR tools | CRISPR tools | CRISPR tools | ||||
| Clones | EXRC - 1 clone(s) | ||||||
| GE Dharmacon | GE Dharmacon | GE Dharmacon | |||||
| Source BioScience | Source BioScience | ||||||
| Antibody | Casp3 Ab1 , Casp3 Ab2 , Casp3 Ab3 , Casp3 Ab4 , Casp3 Ab5 , Casp3 Ab6 | Casp3 Ab3 , Casp3 Ab1 , Casp3 Ab4 | Casp3 Ab1 , Casp3 Ab2 , Casp3 Ab3 , Casp3 Ab4 , Casp3 Ab5 , Casp3 Ab6 | ||||
| Morpholino | casp3 MO1 , casp3 MO2 | casp3 MO1 , casp3 MO2 | casp3 MO1 , casp3 MO2 | ||||
| ORF | casp3.S ORF1 | ||||||
| Affymetrix 1.0 | Str.20292.1.S1_at [+] | Xl.17957.1.S1_at | |||||
| Affymetrix 2.0 | Xl2.17957.1.S2_at [+] | ||||||
Symbol legend[+]
