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Summary Expression Gene Literature (229) GO Terms (32) Nucleotides (360) Proteins (43) Interactants (719) Wiki
Gene Symbol:

Gene Name:
heat shock protein family A (Hsp70) member 5

BiP , grp78 , XAP-1 , immunoglobulin-binding protein ( Add synonyms , Nomenclature history )

Gene Function:
molecular chaperone

Protein Function :
Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded...[+]

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External Links:
Xenbase Gene ID XB-GENE-480060 XB-GENE-17331987 XB-GENE-865337
Gene Symbol hspa5 hspa5.L hspa5.S
Chromosome Chr8 chr8L chr8S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100492570
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein Uniprot NCBI Protein RefSeq  More.. NCBI Protein RefSeq  More..
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine hspa5 hspa5.L hspa5.S
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
HGNC AGR, OMIM:Gene, GeneCards HSPA5 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
MGI, AGR Hspa5 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
RGD, AGR Hspa5 Ensembl
ZFIN, AGR hspa5 ZFIN Ensembl
fruit fly
First Binding to membrane proteins within the endoplasmic reticulum cannot explain the retention of the glucose-regulated protein GRP78 in Xenopus oocytes., EMBO J 1988  
Most Recent Endoplasmic reticulum transmembrane protein TMTC3 contributes to O-mannosylation of E-cadherin, cellular adherence, and embryonic gastrulation., Mol Biol Cell 2020                                        
All View All Papers 4 paper(s) referencing morpholinos 3 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 29 terms 6 terms 2 terms
KEGG Pathways K09490 K09490 K09490
KOG [O] Molecular chaperones GRP78/BiP/KAR2, HSP70 superfamily
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks hspa5
Antibodies Hspa5 Ab1 , Hspa5 Ab2 , Hspa5 Ab3 Hspa5 Ab2 , Hspa5 Ab3
Morpholinos hspa5 MO1 , hspa5 MO2 hspa5 MO1 , hspa5 MO2 hspa5 MO1 , hspa5 MO2
ORFs hspa5.L ORF1 hspa5.S ORF1
Clones Horizon Horizon Horizon Source BioScience
Plasmids Addgene Addgene

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