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Summary Expression Gene Literature (32) GO Terms (3) Nucleotides (152) Proteins (31) Interactants (743) Wiki
XB-GENEPAGE-480485

Gene Symbol: irx3

Gene Name: iroquois homeobox 3

Synonyms: xiro3 , mgc131103 , xiro-3 , irx3b ( Add synonyms , Nomenclature history )

Gene Function: homeodomain transcription factor

Protein Function :
Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Both up-regulates an...[+]

Interactants: Loading ...
Disease Ontology:

OMIM Diseases:

1/9
 
Xenbase Gene ID XB-GENE-480486 XB-GENE-480490 XB-GENE-17335664
Gene Symbol irx3 irx3.L irx3.S
Chromosome Chr04 chr4L chr4S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
Entrez Gene
mRNA RefSeq RefSeq NCBI Nucleotide
Protein RefSeq Swiss-Prot RefSeq Swiss-Prot NCBI Protein TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression
Data Mining tropicalis laevis.L laevis.S
XenMine irx3 irx3.L irx3.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards IRX3 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Irx3 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR ZFIN, AGR irx3a irx3b ZFIN Ensembl
chicken
GEISHA IRX3 Ensembl
fruit fly
worm
WORMBASE
Publications
First Xiro3 encodes a Xenopus homolog of the Drosophila Iroquois genes and functions in neural specification., EMBO J 1998              
Most Recent Genome-wide identification of Wnt/β-catenin transcriptional targets during Xenopus gastrulation., Dev Biol 2017                                      
All View All Papers 9 paper(s) referencing morpholinos 4 paper(s) referencing OMIMs
Functional Ontologies tropicalis laevis.L laevis.S
GO 0 term 0 term 3 terms
PANTHER irx3
KEGG Pathways
KOG [K] Transcription factor MEIS1 and related HOX domain proteins
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones EXRC - 2 clone(s)    
Dharmacon Dharmacon Dharmacon
Morpholino irx3 MO1 , irx3 MO2 , irx3 mismatch cMO , irx3 MO3 irx3 MO1 , irx3 MO2 , irx3 mismatch cMO , irx3 MO3 irx3 MO1 , irx3 MO2 , irx3 mismatch cMO , irx3 MO3
ORF irx3 ORF1 irx3.L ORF1
Affymetrix 1.0 Str.2093.1.S1_at [+] Xl.4522.1.S1_at
Affymetrix 2.0 Xl2.4522.1.S1_at [+] Xl2.53935.1.S1_x_at [+]

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
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