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Summary Expression Gene Literature (33) GO Terms (25) Nucleotides (152) Proteins (33) Interactants (746) Wiki
Gene Symbol: irx3

Gene Name: iroquois homeobox 3

Synonyms: xiro3 , mgc131103 , xiro-3 , irx3b ( Add synonyms , Nomenclature history )

Gene Function: homeodomain transcription factor

Protein Function :
Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Both up-regulates an...[+]

Interactants: Loading ...
Diseases:  External Disease Links: ClinVar, MalaCards, KEGG Disease, DECIPHER
Xenbase Gene ID XB-GENE-480486 XB-GENE-480490 XB-GENE-17335664
Gene Symbol irx3 irx3.L irx3.S
Chromosome Chr04 chr4L chr4S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 407888
mRNA RefSeq RefSeq NCBI Nucleotide
Protein RefSeq Swiss-Prot RefSeq Swiss-Prot NCBI Protein TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining tropicalis laevis.L laevis.S
XenMine irx3 irx3.L irx3.S
MOD Entrez Gene Genetic Phenotypes Gene Expression
OMIM:Gene, HGNC, GeneCards IRX3 OMIM Ensembl, Protein Atlas, Allen Brain Atlas
MGI, AGR Irx3 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
ZFIN, AGR ZFIN, AGR irx3a irx3b ZFIN Ensembl
fruit fly
First Xiro3 encodes a Xenopus homolog of the Drosophila Iroquois genes and functions in neural specification., EMBO J 1998              
Most Recent miR-199 plays both positive and negative regulatory roles in Xenopus eye development., Genesis 2020                          
All View All Papers 9 paper(s) referencing morpholinos 4 paper(s) referencing OMIMs
Functional Ontologies tropicalis laevis.L laevis.S
GO 14 terms 22 terms 3 terms
KEGG Pathways
KOG [K] Transcription factor MEIS1 and related HOX domain proteins
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks irx3
Morpholinos irx3 MO1 , irx3 MO2 , irx3 MO3 irx3 MO1 , irx3 MO2 , irx3 MO3 irx3 MO1 , irx3 MO2 , irx3 MO3
ORFs irx3 ORF1 irx3.L ORF1
Clones EXRC Horizon Source BioScience Horizon Source BioScience Horizon

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
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Version: 4.13.0

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