Gene Symbol: fgf4 Gene Name: fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene) Synonyms: efgf, HBGF-4, XEFGF, fgfe, fgf-4, Xfgf4, Xfgf-4, fgf4-b Add Xenopus synonyms Gene Function: heparin-binding growth factor Interactants: t(42) , fgf8(24) , fgf2(21) , chrd(17) , myod1(17) , bmp4(14) , otx2(13) View All

Molecules		tropicalis	laevis a		laevis b
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene		Entrez Gene
mRNA		Refseq >NM_001142822|Xenopus (Silurana) tropicalis fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene) (fgf4), mRNA ATGACTGTTCCATCGGCCCTGGTGCCAATCCTGCTGCTGGGAATGGCTGCCGTTGTGGTGCAGGGCTTGCCGCTCTCTTCTTCCCTGAGGAATGACACCCTGGAACGGCGATGGGAGACCCTCTTTTCCAGGTCCATGGCTAGGATCCCAGGGGAAAAAAGGGATATGAGCCGGGAAAGTGACTATTTGCTGGGCATCAAGAGGCTGCGACGTCTCTACTGCAACGTGGGCATCGGGTTTCATATCCAGGTTTTACCGGACGGAAGGATAAATGGCATGCACAATGAAAATCGATACAGTTTACTGGAGATTTCCCCAGTGGAAGTGGGAGTTGTGAGTTTGTACGGCGTTAAAAGTGCCATGTTTGTCGCTATGAATGCAAAGGGGAAGCTGTATGGATCAAGACATTTCAATGACGAATGCAAATTCAAAGAGACCCTTCTGCCCAACAACTACAACGCCTACGAATCGAGGAAATACCCCGGCATGTACATCGCTCTGAGCAAAAATGGAAGGACAAAAAAAGGGAACAGAGTTTCTCCGACAATGACACTGACCCATTTCTTGCCCCGGATATGA	Refseq >NM_001085823|Xenopus laevis fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene) (fgf4-a), mRNA GTTGATCGGGATGACTGTTCCATCGGCCCTGGTGCCAATCCTGCTCCTGGGAACGGCTGCCGTCATGGTGCAGTGCCTGCCGCTTTCTTTCCAGAGAAACGACACCGTGGAACGGCGATGGGAGACCCTCTTTTCCAGGTCCATGGGGGAAAAAAAGGATACGAGTCGGGACAGTGACTATTTGCTGGGCATCAAGAGACAGCGGCGTCTTTACTGCAATGTGGGCATCGGGTTTCATATCCAGGTTTTACCGGACGGAAGGATAAATGGCATGCACAGTGAAAATCGATACAGTTTACTGGAGCTTTCCCCAGTGGAAGTTGGAGTCGTGAGTTTATACGGCGTTAAAAGCGGCATGTTTGTTGCTATGAATGCAAAGGGGAAGCTGTATGGATCAAGATATTTCAATGAAGAATGCAAATTCAAAGAGACGCTTCTGCCCAACAACTATAACGCTTACGAATCGAGGAAATACCCCGGCATGTACATCGCTCTGGGCAAAAATGGAAGGACAAAAAAAGGCAACCGGGTTTCTCCGACAATGACGCTGACCCATTTCTTGCCACGGATATGA		Refseq >NM_001085824|Xenopus laevis fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene) (fgf4-b), mRNA GTTGATCAGGATGACTGTTCAATTGGCCCTGGTGCCAATCCTGCTCCTGGGAACGGCTGCCGTTATGGTGCACTGCATGCCGTTCTCTTCTTCCCAGAGAAATGACACCCTGGAACGGAGATGGGAGACCCTCTTTTCCAGGTCCATGGCCAGGATCCCGGGGGAAAAAAAGGATATGAGTCGGGAAAGTGACTATTTGCTGGGCATCAAGAGACTGCGACGTCTTTACTGCAACGTGGGCATCGGGTTTCATATCCAGGTTTTACCGGACGGAAGGATAAATGGCATGCACAACGAAAATCGATACAGTTTACTGGAGATTTCCCCAGTGGAAGTGGGAGTCGTGAGTTTGTACGGCATTAAAAGCGCCATGTTTGTTGCTATGAATGCAAAGGGGAAGCTGTATGGATCAAGATATTTCAACGAGGAATGCAAATTCAAAGAGACACTTCTGCCCAACAACTATAACGCTTACGAATCCAGGAAATACCCCGGCATGTACATTGCTCTGGGCAAAAATGGAAGGACAAAAAAAGGGAACAGAGTTTCTCCGACAATGACACTGACCCATTTCTTGCCACGGATATGA
Protein		Refseq >NP_001136294|fibroblast growth factor 4 precursor [Xenopus (Silurana) tropicalis] MTVPSALVPILLLGMAAVVVQGLPLSSSLRNDTLERRWETLFSRSMARIPGEKRDMSRESDYLLGIKRLRRLYCNVGIGFHIQVLPDGRINGMHNENRYSLLEISPVEVGVVSLYGVKSAMFVAMNAKGKLYGSRHFNDECKFKETLLPNNYNAYESRKYPGMYIALSKNGRTKKGNRVSPTMTLTHFLPRI	Refseq >NP_001079292|fibroblast growth factor 4A precursor [Xenopus laevis] MTVPSALVPILLLGTAAVMVQCLPLSFQRNDTVERRWETLFSRSMGEKKDTSRDSDYLLGIKRQRRLYCNVGIGFHIQVLPDGRINGMHSENRYSLLELSPVEVGVVSLYGVKSGMFVAMNAKGKLYGSRYFNEECKFKETLLPNNYNAYESRKYPGMYIALGKNGRTKKGNRVSPTMTLTHFLPRI UniProtKB		Refseq >NP_001079293|fibroblast growth factor 4B [Xenopus laevis] MTVQLALVPILLLGTAAVMVHCMPFSSSQRNDTLERRWETLFSRSMARIPGEKKDMSRESDYLLGIKRLRRLYCNVGIGFHIQVLPDGRINGMHNENRYSLLEISPVEVGVVSLYGIKSAMFVAMNAKGKLYGSRYFNEECKFKETLLPNNYNAYESRKYPGMYIALGKNGRTKKGNRVSPTMTLTHFLPRI UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis a		laevis b
UniGene		Str.84471	Xl.1180		Xl.1181
Unigene EST Profile		EST Profile	EST Profile		EST Profile
GEO data			GEO		GEO
Images		12 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	FGF4
mouse		MGI	Fgf4	All(8) Targeted, knock Out(5) Targeted, other(4)
zebrafish		ZFIN	fgf4

Publications
First:		Specification of the body plan during Xenopus gastrulation: dorsoventral and anteroposterior patterning of the mesoderm. [Dev Suppl 1992]
Most recent:		Lin28 proteins are required for germ layer specification in Xenopus. [Development 2013]
		View All Papers 19 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		growth factor activity
Biological:
Cellular Component:
EC:
KOG:		[T] Fibroblast growth factor

Reagents		tropicalis	laevis a		laevis b
Clones			EXRC - 1 clone(s)
		open biosystems	open biosystems		open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes		geneservice/RZPD imagenes
Affymetrix 1.0		StrEns.2552.1.S1_at	Xl.1180.1.S1_at		Xl.1181.1.S1_at
Affymetrix 2.0			Xl2.1180.1.S1_at		Xl2.1181.1.S1_at

Symbol legend[+]

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