Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (145) GO Terms (20) Nucleotides (41) Proteins (27) Interactants (973) Wiki
XB-GENEPAGE-480495
Gene Symbol:
fgf4

Gene Name:
fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene)

Synonyms:
efgf , HBGF-4 , XEFGF , fgfe , fgf-4 , Xfgf4 , Xfgf-4 , fgf4-b , fgf4-a ( Add synonyms , Nomenclature history )

Gene Function:
heparin-binding growth factor

Protein Function :
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Good candidate for an inducing factor with possible roles both in mesoderm induction at...[+]


InterPro :
TSP1 rpt sf , ConA-like dom sf , Thrombospondin C , EGF dom [+]

Interactants:
Loading ...

Diseases: 


External Links:
1/5
 
Xenbase Gene ID XB-GENE-480496 XB-GENE-6252641 XB-GENE-865382
Gene Symbol fgf4 fgf4.L fgf4.S
Chromosome Chr04 chr4L chr4S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100217325
378586
378587
mRNA RefSeq RefSeq RefSeq
Protein NCBI Protein RefSeq RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine fgf4 fgf4.L fgf4.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards FGF4 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Fgf4 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Fgf4 Ensembl
zebrafish
ZFIN, AGR fgf4 ZFIN Ensembl
chicken
GEISHA FGF4 Ensembl
fruit fly
worm
Publications
First Mesoderm-inducing properties of INT-2 and kFGF: two oncogene-encoded growth factors related to FGF., Development 1989  
Most Recent Mechanical Stress Regulates Epithelial Tissue Integrity and Stiffness through the FGFR/Erk2 Signaling Pathway during Embryogenesis., Cell Rep 2020                  
All View All Papers 29 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 2 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 16 terms 7 terms 7 terms
PANTHER fgf4
KEGG Pathways K04358 K04358 K04358
KOG [T] Fibroblast growth factor
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks fgf4
Morpholinos fgf4 MO1 fgf4 MO1 fgf4 MO1
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
Xenbase: The Xenopus Model Organism Knowledgebase.
Version: 4.15.0
Major funding for Xenbase is provided by grant P41 HD064556